CIRRHOSIS

This study tests whether empagliflozin, a diabetes drug, can prevent liver scarring (fibrosis) from getting worse in people with chronic hepatitis B. About 106 adults with moderate to severe liver scarring will take either the drug or a placebo daily for three years. The goal is …

This study tests whether simvastatin, a drug typically used for cholesterol, can reduce the risk of serious liver problems in veterans with early-stage cirrhosis (scarred liver but no symptoms yet). About 142 participants will receive either simvastatin or a placebo to see if it …

This study compares a drug called Angiotensin II to the usual treatment for raising blood pressure in people with liver disease who have a dangerous drop in blood pressure (shock). The goal is to see if Angiotensin II helps the heart and blood vessels work together better. About …

This study is testing whether a new scoring system called GAAD, which uses a patient's age, gender, and two blood markers, can better detect liver cancer early in people with chronic liver disease. About 2,100 adults at high risk for liver cancer will be followed over time. The g…

This study is testing a new blood test called Oncoguard™ Liver to see how well it finds liver cancer early in people who are at high risk, such as those with cirrhosis or hepatitis B. About 3,000 adults will take part, and the test's accuracy will be compared to standard ultrasou…

This study tests whether simvastatin, a widely used cholesterol medication, can stop liver cancer from developing in people with liver cirrhosis. About 52 adults with confirmed cirrhosis will take simvastatin, and researchers will measure changes in blood markers linked to liver …

This early-phase trial studies the safety and best dose of radiation therapy for people with liver cancer (hepatocellular carcinoma, cholangiocarcinoma, or cancer that spread to the liver) who also have liver damage from cirrhosis, chemotherapy, or surgery. About 36 participants …

This study looks at how dental checkups and cleanings affect the health of 100 adults with cirrhosis. Researchers want to find out what stops these patients from getting good oral care and whether regular dental visits can improve their overall health. The goal is to learn more, …

This study follows up to 500,000 adults with chronic liver disease or cirrhosis to learn how the disease progresses and how well current treatments work. Participants are observed through their regular medical care, and some are asked to provide additional information. The goal i…

This study looks at how liver cirrhosis impacts trauma patients' outcomes, especially death and infections. Researchers will analyze data from over 4.7 million adults in the US treated for injuries between 2010 and 2018. The goal is to understand if cirrhosis makes recovery harde…

This study tests a decision aid tool that helps VA medical centers choose the best strategies to improve liver cancer screening in patients with cirrhosis. About 8,020 veterans and VA staff will take part. The goal is to see if the tool increases screening rates and catches cance…

This study looks at two strategies to get more veterans tested for colon and liver cancer: directly contacting those who need screening, or helping healthcare providers fix delays. Researchers will compare how many people get tested over a year at different sites. The goal is to …

This study re-examines 317 adults with type 2 diabetes who were first checked between 2019 and 2023. Researchers use advanced scans and blood tests to see how many have fatty liver disease (MASLD) and whether it has gotten better or worse over time. The goal is to learn what fact…

This study tests whether an automatic reminder in the medical record helps doctors order liver ultrasounds for patients with cirrhosis. About 1,300 adults with cirrhosis who haven't had recent imaging will be included. The goal is to see if the reminder increases screening rates …

This study follows 1,222 adults with liver cirrhosis over time to understand why some develop serious complications like fluid buildup or confusion. Participants have check-ups every 6 months, including questionnaires, physical exams, and imaging. The goal is to create better pre…

This study was designed to measure and compare estrogen and testosterone levels in men with cirrhosis who also have low blood pressure versus those with normal blood pressure. The goal was to better understand why low blood pressure occurs in cirrhosis. However, the study was wit…