Cirrhosis

This study looks at whether giving a protein called albumin through a vein can help improve thinking and memory in people with liver cirrhosis who have had episodes of confusion (hepatic encephalopathy). The trial will involve 30 participants who will receive both albumin and a p…

This study tests whether capsules containing bacteria from healthy people can safely reduce alcohol cravings and drinking in adults with alcohol-related liver disease and cirrhosis. About 80 participants will receive either the bacteria capsules or a placebo, and researchers will…

This study tests whether technology and caregiver support can help liver transplant recipients take their medications correctly. Researchers will enroll 360 adults who received a liver transplant within the past 3 months. Participants will use a system called Way to Health, which…

This study tests whether a drug called Angiotensin II can raise blood pressure more effectively than standard medications in people with liver cirrhosis who have septic shock. Researchers will measure how well the heart and blood vessels work together over 24 hours. The trial inv…

This study tests whether empagliflozin, a diabetes drug, can prevent liver scarring (fibrosis) from getting worse in people with chronic hepatitis B. About 106 participants with moderate to severe liver scarring will take either empagliflozin or a placebo daily for three years. T…

This study tests whether simvastatin, a drug typically used for cholesterol, can reduce the risk of liver complications in veterans with compensated cirrhosis (scarred but symptom-free liver). About 142 participants will take either simvastatin or a placebo nightly for several ye…

This study tests whether transplanting healthy gut bacteria from donors can improve confusion in people with advanced liver disease. Thirty participants will receive either fecal transplant capsules or a placebo. The goal is to see if this approach can safely improve thinking and…

This study tests an AI tool called LEAF that helps doctors analyze CT scans of the abdomen to find liver cancer early. Researchers will use scans from 10,000 patients with confirmed liver tumors to train the AI to better detect cancer. The goal is to improve early screening and g…

This study is testing whether a new blood test score, called GAAD, can detect liver cancer earlier in people with chronic liver disease. The GAAD score combines a person's gender, age, and two blood markers (AFP and PIVKA-II). Researchers will compare the GAAD score to standard u…

This study is testing a new blood test called Oncoguard Liver to see how well it detects liver cancer (hepatocellular carcinoma) in people at increased risk, such as those with cirrhosis or hepatitis B. About 3,000 participants will provide a blood sample and undergo imaging like…

This study is testing whether a device that delivers mild electrical stimulation through the skin (called TEA) can help with chronic pain and depression in people with cirrhosis. Thirty participants will use the device at home twice daily for 8 weeks, or a sham version. The main …

This trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The study is small and early-stage, focused on understanding how the device works and whether it is safe. No results are available yet, and the device is not ready for widespread use.

This study compares two strategies to increase colon and liver cancer screening among 30,300 veterans. One approach directly reaches out to veterans to schedule tests, while the other helps healthcare providers fix system issues. Researchers will track screening rates over 12 mon…

This study aims to find biological markers in blood, urine, stool, and breath that can predict how patients with acute liver injury or failure will fare. Researchers will collect samples daily for up to seven days from 200 participants, and a small group will also undergo MRI sca…

This study looks at 300 patients with advanced liver scarring (cirrhosis) caused by hepatitis B or alcohol who have shown signs of getting better. Researchers want to understand what predicts this improvement and how long it lasts. The goal is to create clearer guidelines for whe…

This study looks at whether offering dental exams and cleanings to people with cirrhosis can improve their oral health and overall well-being. Researchers will also ask participants about barriers to getting dental care. About 100 adults with confirmed cirrhosis will take part, a…

This study was designed to measure estrogen and testosterone levels in men with liver cirrhosis who also have low blood pressure, compared to those with cirrhosis but normal blood pressure. The goal was to understand why low blood pressure occurs in cirrhosis. However, the study …

This observational study will follow up to 500,000 adults with chronic liver disease or cirrhosis to understand how the disease progresses and how treatments are used in everyday practice. Researchers will collect data from medical records and patient reports to improve care and …

This study tests whether an automatic reminder in the electronic health record can increase the number of cirrhosis patients who get screened for liver cancer (hepatocellular carcinoma). The reminder prompts doctors to order a liver ultrasound when they see a patient with cirrhos…

This study tests a new decision aid tool (OASIS) that helps VA hospitals choose the best strategies to improve screening for liver cancer in patients with cirrhosis. Over 8,000 veterans and clinicians at multiple VA medical centers will participate. The goal is to see if the tool…

This observational study follows 1,222 adults with liver cirrhosis to understand why some develop serious complications like fluid buildup or bleeding. Participants have check-ups every six months, including questionnaires, physical exams, and imaging. The goal is to build better…

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…