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Tiny plastics, big trouble? new study probes microplastic impact on liver disease

NCT ID NCT07280390

Knowledge-focused Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will check for microplastics in liver tissue from 30 people with cirrhosis who are having surgery or a liver transplant. Researchers want to see if these tiny plastic particles are linked to worse liver damage, higher blood pressure in the liver, and heart problems. The goal is to understand how plastic pollution might affect chronic liver disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how microplastics contribute to liver damage and heart problems in people with cirrhosis, pointing toward ways to reduce those risks.
What could go wrong
This is a very small, early observational study with only 30 participants. It cannot prove cause and effect, and results may not apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Cirrhosis Healthy liver control tissue will be taken from autopsy patients with consent

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age range of 18-70 years * Cirrhosis, as diagnosed by histology or clinical, laboratory and USG findings. * Undergoing elective surgery or liver transplantation Exclusion Criteria: * • Hepatocellular carcinoma * Pregnancy or lactation * Patients with HIV or retroviral therapy * Prior liver interventions like locoregional therapy, presence of HCC, prior abdominal surgery

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver Fibrosis portal hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cirrhosis Cirrhosis and chronic liver disease Microplastics Nanoplastics Pollution Portal hypertension related to cirrhosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dr. Madhumita Premkumar

    RECRUITING

    Chandigarh, Chandigarh, 160012, India

  • PGIMER Chandigarh

    RECRUITING

    Chandigarh, Chandigarh, 160012, India

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