CIRRHOSIS, LIVER

This study is testing whether a special nutritional supplement containing extra leucine (an amino acid) can help rebuild lost muscle in people with liver cirrhosis. Researchers will compare this supplement to a standard nutritional mix in 32 participants over 3 months. The goal i…

This is an early-stage study to test the safety and dosing of a new drug called PHIN-214 in people with liver cirrhosis. The drug is given as an injection under the skin, first as a single dose and then as daily doses for up to 28 days. The main goal is to see how much of the dru…

This study is testing two different approaches for giving intravenous fluids to hospitalized patients with liver cirrhosis who develop sudden kidney injury. Researchers want to see if a personalized fluid guidance algorithm is safe, effective, and practical compared to the standa…

This early-stage study is testing the safety of an investigational drug called siplizumab in patients with autoimmune liver disease who are receiving a liver transplant. The drug is given right after surgery to help prevent the body's immune system from attacking the new liver. U…

This early-stage trial is testing whether specially designed mixtures of helpful gut bacteria are safe for people hospitalized with serious liver disease. Researchers want to see if these bacterial mixtures can restore a healthier gut environment, which is often damaged in liver …

This is the first study in people to test a new personalized cell therapy called RTX001 for advanced liver disease. The therapy is made by collecting a patient's own white blood cells, engineering them in a lab to potentially reduce liver scarring and inflammation, and then retur…

This study is testing whether an intensive monitoring program helps people with cirrhosis and fluid buildup stay healthier after leaving the hospital. Patients receive a digital scale, educational materials, weekly check-in calls, and early follow-up appointments. Researchers wil…

This study is testing whether a special amino acid supplement can help reverse muscle loss in people with liver cirrhosis. Muscle wasting is a common and serious complication that worsens health outcomes. Researchers will compare the supplement to a placebo over 3 months to see i…

This study is testing whether a cholesterol-lowering drug called rosuvastatin can safely slow the progression of liver cirrhosis. It will involve about 256 adults with early-stage cirrhosis who are not yet experiencing severe complications. Participants will take either the drug …

This study is testing whether a combination of two immunotherapy drugs (tremelimumab and durvalumab) is safe and effective for people with advanced liver cancer who also have moderately impaired liver function, known as Child-Pugh B cirrhosis. It focuses on including patients fro…

This study is comparing two ways to give fluids and medications to liver patients with severe, life-threatening infections (sepsis). One method uses a bedside heart ultrasound to carefully guide treatment, while the other follows a standard protocol. The goal is to see if the ult…

This study is testing a new, non-invasive type of MRI scan to measure pressure in the liver's blood vessels (portal hypertension) in people with cirrhosis. The goal is to see if this scan can accurately predict the results of the current invasive test, which requires a needle. If…

This study is testing a new type of MRI scan to find dangerous, swollen veins in the esophagus of people with advanced liver disease (cirrhosis). These veins can burst and cause fatal bleeding. The goal is to see if this non-invasive scan can accurately identify which patients ne…

This study aims to develop a simple, non-invasive breath test to help diagnose liver cirrhosis earlier. Researchers will give participants a safe drink containing food additives and analyze their breath to see if changes in metabolism can reveal liver damage. The goal is to creat…

This study is testing whether a compound from green tea (EGCG) can help prevent liver cancer in people with cirrhosis, a serious liver condition. Sixty participants with high risk for liver cancer will take either EGCG capsules or a placebo for 24 weeks. Researchers will measure …

This study aims to check how well a specific diagnostic scoring system works for identifying a dangerous immune system overreaction called HLH in critically ill patients with liver problems. Researchers will look back at the medical records of 100 adults who were treated in a Fre…

This study aims to understand if high pressure inside the belly is linked to more fluid from the stomach getting into the lungs of critically ill patients with liver cirrhosis who are on breathing machines. Researchers will monitor belly pressure and test fluid from patients' bre…

This study aims to understand how a hepatitis D treatment called bulevirtide affects gut bacteria and bile acids in patients. Researchers will follow 20 patients with hepatitis D and liver damage, collecting samples over 48 weeks to see how these gut factors change during treatme…

This study aims to understand how different types of exercise affect muscle loss in people with cirrhosis, a serious liver condition. Researchers will compare 12 weeks of supervised endurance cycling to supervised resistance training in 40 participants. The goal is to learn which…

This study aims to understand the non-medical challenges, like financial strain or housing issues, that people with chronic liver disease face. Researchers will survey 400 patients and their doctors at Indiana University to see how common these problems are and whether patients w…