CIRRHOSIS, LIVER

This study tests whether using a bedside heart ultrasound (POCUS) to guide fluid and medication decisions improves outcomes for 140 adults with liver cirrhosis and severe sepsis or septic shock, compared to standard guideline-based care. The goal is to give just enough fluids to …

This study tests whether a special mix of amino acids (HMB-enriched) can reverse muscle loss in people with cirrhosis. About 24 participants will take either the active supplement or a placebo for 3 months. The goal is to see if the supplement helps build muscle and improve healt…

This study tests a home-based program called LiverWatch for people with advanced liver disease (cirrhosis). Participants get a Fitbit, personalized nutrition advice, and weekly education. The goal is to see if this helps improve physical activity, diet, and overall well-being com…

This study tests whether a 12-week online program of exercise, nutrition advice, and behavioral support can improve physical function in people waiting for a liver transplant. About 177 adults with cirrhosis who are frail or pre-frail will be recruited from six Canadian transplan…

This study is testing whether a leucine-enriched amino acid mixture can help reverse muscle loss in people with liver cirrhosis. About 32 participants will take either the special mixture or a control mixture for 3 months. Researchers will measure changes in muscle protein produc…

This study looks at two ways to give fluids to people with cirrhosis who develop acute kidney injury. One method uses a special algorithm to guide fluid choice, while the other follows standard care. The goal is to see which approach is safer and works better. About 50 hospitaliz…

This study tests a transitional care program for adults with cirrhosis and severe swelling (fluid overload) who are being discharged from the hospital. Participants get a digital scale, educational materials, weekly check-in calls, and a follow-up appointment within 4 weeks. Rese…

This early-stage trial tests whether giving a mix of healthy gut bacteria to people hospitalized with liver disease is safe and tolerable. The bacteria come from healthy donors and are designed to restore missing gut microbes. 24 adults with liver failure or cirrhosis will receiv…

This study tests a combination of two immunotherapy drugs, tremelimumab and durvalumab, in 32 people with advanced liver cancer who also have moderate liver cirrhosis (Child-Pugh-B). The main goal is to see if this treatment is safe and tolerable. The study focuses on patients of…

This early study tests whether siplizumab can safely prevent the immune system from attacking a new liver in people with autoimmune hepatitis or primary sclerosing cholangitis. Eight participants will receive two doses of the drug around the time of transplant and be monitored fo…

This study tests an experimental drug called PHIN-214 in 74 adults with mild-to-moderate liver cirrhosis (Child-Pugh A or B). The goal is to find a safe dose and see how the body handles the drug. It is an early-phase trial focused on safety, not a cure.

This study tests whether rosuvastatin, a widely used cholesterol medication, can safely slow or prevent liver scarring and complications in people with cirrhosis. Researchers will enroll 256 adults with early-stage cirrhosis from causes like fatty liver, alcohol, or hepatitis. Pa…

This study tests a new treatment called RTX001 for people with severe liver cirrhosis that has caused complications. RTX001 uses the patient's own immune cells (macrophages) that are modified in a lab to reduce inflammation and scarring in the liver. The trial will enroll 30 adul…

This study tests a special MRI technique (4D flow MRI) to find enlarged veins in the stomach and esophagus that can cause fatal bleeding in people with severe liver disease (cirrhosis). Currently, doctors use a camera scope down the throat to check for these veins, which is uncom…

This study is testing whether a breath test can help identify people who may have liver cirrhosis, a serious scarring of the liver. Researchers will give participants a safe food additive and measure specific compounds in their breath. The goal is to create a risk score that doct…

This study tests whether a compound from green tea, EGCG, can lower the risk of liver cancer in people with liver cirrhosis. About 60 adults with cirrhosis but no prior liver cancer will take either EGCG or a placebo for several months. Researchers will measure changes in a blood…

This study looks at how 12 weeks of either resistance or endurance exercise changes muscle mass in people with cirrhosis, a liver condition that often leads to muscle loss. Researchers will compare these two types of exercise to standard care in 40 adults. The goal is to understa…

This study is testing whether a special MRI scan (3D-MRE) can accurately measure pressure in the liver's blood vessels, which is important for managing cirrhosis and advanced liver disease. Currently, doctors must insert a thin tube into a neck vein to measure this pressure, whic…

This study looks at how well a tool called the HScore can diagnose hemophagocytic lymphohistiocytosis (HLH), a serious overreaction of the immune system, in intensive care patients with liver failure or cirrhosis. Researchers will review medical records of 100 adults admitted to …

This study looks at adults with cirrhosis who are waiting for a liver transplant but do not have diabetes. The goal is to find out if simple tests like blood work, glucose monitors, and activity trackers can predict who will develop diabetes after the transplant. Participants wea…

This study looks at whether high pressure in the belly (intra-abdominal hypertension) causes more fluid to leak into the lungs of liver disease patients who are on breathing machines. Researchers will measure belly pressure and check lung fluid for signs of stomach contents. The …

This study aims to find out why some people with fatty liver disease or alcohol-related liver disease develop liver cancer. Researchers will look at genetic markers, immune system factors, and medical images from 710 adults with and without cirrhosis. The goal is to catch early s…

This study tracks 20 adults with chronic hepatitis delta (a serious liver infection) who are starting a new drug called bulevirtide. Researchers want to see how the drug changes the gut's bacteria and bile acids over 48 weeks, and how those changes relate to inflammation and live…

This study looks at the social and economic challenges faced by people with chronic liver disease, such as trouble paying for food or housing. Researchers will survey 400 patients and their doctors to find out what needs are most common and whether patients want their medical tea…