CIRRHOSIS, LIVER

This study tests whether a structured exercise program before and after liver transplant helps patients recover faster and have fewer complications. Sixty adults awaiting a liver transplant will take part. The program includes supervised training before surgery and continued exer…

This study tests whether a personalized disease management program can help people with early liver disease (fatty liver or fibrosis) improve their liver health. About 49 participants will receive either the tailored program or standard care. The main goal is to see if the progra…

This study looks at whether a supervised ketogenic diet is safe and effective for weight loss in 40 obese adults with NASH cirrhosis. Participants are randomly assigned to either the ketogenic diet or standard dietary advice for 16 weeks. The main goals are to check for liver com…

This study looks at whether a type of diabetes medication called SGLT-2 inhibitors can help control ascites (fluid buildup in the belly) in people with liver cirrhosis and type 2 diabetes. Researchers will compare 40 patients who receive the drug plus standard care against those …

This study looks at whether giving antibiotics before an endoscopic procedure is necessary for cirrhosis patients who have had variceal bleeding before. The goal is to see if skipping antibiotics is just as safe and effective. About 226 adults with cirrhosis are taking part.

This study aimed to see if the antibiotic rifaximin could help people with liver cirrhosis who have a hidden form of brain fog (covert hepatic encephalopathy) and an overgrowth of bacteria in the small intestine. Researchers planned to give 40 patients rifaximin for 8 weeks and t…

This study tests whether beta-blockers, a type of blood pressure medication, can reduce the risk of bleeding from small esophageal varices in people with cirrhosis and portal hypertension. About 763 adults with small varices will receive either beta-blockers or a placebo for up t…

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care, or…

This study explores how social and financial factors—like income, education, and out-of-pocket costs—affect people with cirrhosis and their caregivers. Researchers will survey participants and their caregivers to measure financial distress and healthcare use. The goal is to bette…

This study looks at how often nonalcoholic fatty liver disease (NAFLD) and advanced liver scarring occur in adults with type 1 diabetes. About 533 participants from a diabetes clinic will get a quick, painless liver scan and blood tests. The goal is to find those at highest risk …

This study looks at levels of a substance called 4beta-hydroxycholesterol in the blood of people with liver cirrhosis. Researchers will compare these levels to those in people with pneumonia, Crohn's disease, or ulcerative colitis. The goal is to understand how cirrhosis and its …

This study follows 1,222 adults with liver cirrhosis over time to understand why some develop serious complications like fluid buildup or confusion. Participants have check-ups every 6 months, including questionnaires, physical exams, and imaging. The goal is to create better pre…

This study follows about 850 adults with severe liver cirrhosis who are scheduled for a TIPS procedure—a shunt placed in the liver to reduce dangerous blood pressure. Researchers will collect real-world data over 5 years to learn how to best use TIPS and manage its side effects, …