Can a keto diet help obese patients with advanced liver disease?
NCT ID NCT04383951
First seen Apr 25, 2026 · Last updated Jun 21, 2026 · Updated 9 times
Summary
This study tests whether a monitored ketogenic diet is safe and effective for weight loss in 40 obese adults with compensated NASH cirrhosis. Participants are randomly assigned to either a ketogenic diet or standard dietary advice for 16 weeks. The main goals are to check for liver complications and see how well people tolerate the diet.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Indiana University School of Medicine
Indianapolis, Indiana, 46202, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketogenic diet
What this could lead to
If successful, this could show that a ketogenic diet is a safe way for people with NASH cirrhosis to lose weight and potentially improve liver health.
What could go wrong
This is a small, early-stage study with only 40 people. The diet may be hard to follow, and results may not apply to everyone. There is also a risk of liver complications.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.