HEPATOCELLULAR CANCER

This Phase 1 trial tests a new treatment for people with advanced solid tumors that express a protein called GPC3, including liver cancer. The treatment uses the patient's own T cells, which are modified in a lab to better recognize and attack cancer cells. Participants receive c…

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, and liver cancers. The trial has two parts: first, finding a safe dose (p…

This early-phase trial is testing whether combining internal radiation (SIRT) with two immunotherapy drugs (durvalumab and tremelimumab) is safe and tolerable for people with liver cancer that can be surgically removed. The 20 participants will receive the combination before thei…

This study tests a personalized vaccine made from a patient's own immune cells combined with an immunotherapy drug (nivolumab) to prevent liver cancer from returning after surgery. It includes 60 adults with liver cancer or colorectal cancer that has spread to the liver. The goal…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This study tests a new medicine called PF-08634404, given alone or with another drug (ipilimumab), for adults with advanced liver cancer that cannot be removed by surgery. The goal is to see if the treatment is safe and can shrink tumors. Participants must be 18 or older and have…

This early-phase study tests an investigational drug called ABBV-324 in about 232 adults with liver cancer (hepatocellular carcinoma) or a type of lung cancer (squamous non-small cell lung cancer). The main goals are to check safety, find the right dose, and see if the drug shrin…

This study collects samples from 320 people, including those with solid cancers (like lung, colon, or pancreatic cancer) and those undergoing lung cancer screening, to look for cancer cells and DNA in blood, urine, and bone marrow. The goal is to learn how cancer spreads and find…

This study looks at blood, urine, and bone marrow samples from 620 people with solid cancers (like lung, colon, or pancreatic cancer) to find and measure tumor cells and DNA. The goal is to better understand how cancer spreads and returns after surgery. Participants include cance…