HEPATOCELLULAR CANCER

This early-phase study tests a new treatment where a person's own immune cells are modified in a lab to better recognize and attack cancer cells that have a specific marker called GPC3. The main goal is to see if this therapy is safe for adults with advanced liver cancer or other…

This early-stage trial tests a new drug called MDX2001 in about 285 people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. This is a first-in-human study, so researchers are also finding the best dose to …

This study tests a new medicine called PF-08634404, given alone or with another drug (ipilimumab), for adults with advanced liver cancer that cannot be removed by surgery. The goal is to see if the treatment is safe and can shrink tumors. Participants must be 18 or older and have…

This study tests a personalized vaccine made from a patient's own immune cells, combined with an immunotherapy drug (nivolumab), to prevent liver cancer from returning after surgery. It includes 60 adults with liver cancer or colorectal cancer that has spread to the liver. The go…

This study tests an experimental oral drug called 7HP349 (Alintegimod) taken with standard immunotherapy drugs (ipilimumab and nivolumab) for people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see…

This study is for people with liver cancer that can be surgically removed. It tests whether adding a combination of two immunotherapy drugs (durvalumab and tremelimumab) with or without tiny radioactive beads (SIRT) before surgery is safe and helps shrink the tumor. About 20 part…

This early-phase study tests an investigational drug called ABBV-324 in about 232 adults with liver cancer (hepatocellular carcinoma) or a type of lung cancer (squamous non-small cell lung cancer). The main goals are to check safety, find the right dose, and see if the drug shrin…

This study looks at blood, urine, and bone marrow samples from 620 people with solid cancers (like lung, colon, or pancreatic cancer) to find and measure tumor cells and DNA. The goal is to better understand how cancer spreads and returns after surgery. Participants include cance…

This study collects samples from 320 people, including cancer patients and those undergoing lung cancer screening, to measure tumor cells and DNA in blood, urine, and bone marrow. The goal is to learn more about how cancer spreads and to improve early detection and personalized t…