Imperial College London

This phase 2 trial tests whether an experimental drug called XBD173 can improve blood flow in the brains of people with Alzheimer's disease. About 51 participants will take the drug or a placebo for 28 days. Researchers will use MRI scans and blood tests to measure changes in bra…

This study aimed to transplant insulin-producing cells into the front chamber of the eye for people with type 1 diabetes. The goal was to see if the procedure was safe for the eye. However, the study was withdrawn before any participants were enrolled, so no results are available…

This study tests a combination of chemotherapy (etoposide and carboplatin) plus an immunotherapy drug (pembrolizumab) followed by two maintenance drugs (pembrolizumab and lenvatinib) in 20 people with advanced high-grade neuroendocrine tumors who have not had chemotherapy before.…

This study tests a drug called tezepelumab in 42 adults with EGPA, a rare disease that causes inflammation in blood vessels and can damage organs. The goal is to see if the drug helps patients reach remission, meaning no active disease and low steroid use. Participants receive ei…

This study aimed to see if the drug capivasertib could clear cancer DNA from the blood of women with ER-positive breast cancer who had finished initial treatment. The goal was to prevent the cancer from coming back or spreading. However, the study was withdrawn before any partici…

This early-stage study tests the safety of dostarlimab, an immunotherapy drug, in people with HIV-related Kaposi sarcoma that hasn't responded to standard HIV treatment. About 15-20 participants will receive the drug alongside their HIV therapy. The goal is to see if the drug is …

This study looks at how an experimental drug called XBD173 attaches to a protein (TSPO) in the lungs of 16 healthy volunteers. Using PET scans, researchers will measure how much of the drug is needed to block the protein and whether food affects drug levels. The goal is to gather…

This study tests whether using smart devices (a watch and sleep mat) with a personalized habit coaching app can help older adults adopt healthier behaviors. Thirty people aged 65 and older living in London will either use the coaching app, a standard app, or receive an education …

This study tests whether sending mailed invitations and assigning patient navigators can increase attendance at liver cancer ultrasound screenings for people with cirrhosis or chronic hepatitis B. Over 650 participants will be split into two groups: one receiving these extra supp…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …