Imperial College London

This study tests whether a daily low dose of tadalafil (a drug used for erectile dysfunction) is safe and can help slow memory loss in people with early Alzheimer's or mild cognitive impairment. About 244 participants will take the drug for one year while researchers monitor side…

This study tests whether an automated insulin delivery system (a smart pump that adjusts insulin automatically) can improve blood sugar control and quality of life in people with type 2 diabetes who are on kidney dialysis. About 84 participants will be randomly assigned to either…

This study aims to improve a non-invasive breath test for stomach and esophageal cancers. Researchers will collect breath samples from 6,000 adults referred for suspected cancer to see if certain chemicals in the breath can reliably indicate the presence of cancer. The goal is to…

This early-phase trial tests whether maralixibat is safe and can reduce severe itching in pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver condition that raises bile acids. About 28 women with a single pregnancy between 20 and 35 weeks will take the drug. …

This study will collect heart sound and ECG recordings from 1,000 adults who are already scheduled for an echocardiogram. Researchers will use this data to test and improve artificial intelligence (AI) algorithms designed to detect pulmonary hypertension and other cardiovascular …

This study looks at whether doctors are properly reporting small cancer spots called tumor deposits in rectal cancer patients. These deposits can signal a higher risk of cancer returning, but they were often missed under older staging systems. Researchers will compare reports fro…