Imperial College London

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study tests whether tadalafil, a drug used for erectile dysfunction, is safe and might help people with early Alzheimer's or mild memory problems. Researchers will give 244 participants either tadalafil or a placebo daily for one year. They will check for side effects and me…

This study tests whether oral semaglutide, a drug used for diabetes, is safe and can slow Alzheimer's disease. Sixty people with mild Alzheimer's will take the drug for one year. Researchers will check for side effects and use brain scans to see if the drug protects brain cells.

This study will check if a blood test can find signs of Alzheimer's disease in people with early memory concerns. Researchers will test 1,000 adults aged 55 and older in primary care. The goal is to see if blood markers for amyloid and tau proteins match those found in spinal flu…

This study will test a new type of PET/CT scanner (called long-axial field-of-view) to see if it can provide clearer images of inflammation in the blood vessels of people with large vessel vasculitis. Researchers will compare scans from 18 participants (12 with vasculitis and 6 h…

This study aims to improve a non-invasive breath test for stomach and esophageal cancers. Researchers will collect breath samples from 6,000 adults referred for suspected cancer to see if certain compounds in the breath can reliably signal the presence of these cancers. The goal …

This study tests whether modafinil, a drug used for narcolepsy, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 participants will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a larger trial is possible, bu…

This early-stage study tests a drug called maralixibat in 28 pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes severe itching and high bile acids. The main goal is to see if the drug is safe and tolerable for both mother and baby. Rese…

This study looks at how much women understand about having their labour started with medicine (induction) and how that knowledge affects their birth experience. About 82 pregnant women and 20-30 maternity staff will complete surveys and optional interviews before and after birth.…

This study will give healthy, vaccinated adults aged 18-50 a small dose of the Omicron EG.5.1 virus through nose drops to see how many develop a mild infection. The goal is to create a safe, controlled model for testing future COVID-19 vaccines and treatments. Participants will s…

This study will compare four different ways of following up with men after they have been treated for prostate cancer: hospital visits, GP visits, shared care, or self-management. The goal is to see which approach is safest, most effective, and makes the best use of NHS resources…

This study will follow 500 transgender adults starting gender-affirming hormone therapy to see how their immune systems change. By tracking immune cells and blood markers before and during treatment, researchers hope to understand why men and women have different rates of autoimm…

This study looks at how changes in the cells lining blood vessels relate to lung resistance in people with pulmonary artery hypertension (PAH). Researchers will measure certain blood markers and lung pressure in 6 adults with PAH. The goal is to better understand the disease, not…

This study looks at whether doctors are properly reporting small cancer spots called tumor deposits in people with rectal cancer. These spots can show if the cancer is more aggressive and might need extra treatment like chemo or radiation. Researchers will compare reports from be…

This study will collect heart sound and ECG recordings from 1,000 adults undergoing routine echocardiograms. The goal is to test whether artificial intelligence (AI) can accurately detect pulmonary hypertension and other heart conditions from these recordings. If successful, this…