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Could a simple breath test catch stomach cancer early?

NCT ID NCT07260734

Diagnosis Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new breath test to detect cancers of the stomach and esophagus. Participants provide a breath sample before and after drinking a special liquid. The test looks for chemicals in the breath that may signal cancer. The goal is to see if the drink makes these chemicals easier to detect, improving accuracy. 6000 adults referred for suspected cancer will take part.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oral Stimulant Drink (glucose, glycerol, iron sulphate, thickener, amino acids)
What this could lead to
If successful, this could lead to a simple, non-invasive breath test to detect stomach and esophageal cancers earlier, potentially improving survival rates.
What could go wrong
This is an early-stage validation study. The test may not be accurate enough for widespread use, and results may not apply to all populations. The drink may cause discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 6,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals aged 18 years or over with suspected cancer, referred from primary care for further specialized investigations.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged ≥ 18 years old. * Participants referred from primary care according to the urgent suspected cancer referral guidelines for potential underlying oesophagogastric cancer a for the reference test (described below). * Willing and able to provide informed written consent to take part in study. Exclusion Criteria: * Previous oesophageal or gastric resection * History of cancer within three years (other than non-melanoma skin cancers) * Co-morbidities preventing breath collection * Pregnant participants * Allergies to any of the constituents of the nutrient drink including glucose, glycerol, iron sulphate, Maltodextrin (Corn, Potato), Xanthan Gum, Potassium Chloride, tyrosine, phenylalanine, and glutamic acid * Unable or unwilling to provide informed written consent.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus carcinoma of esophagus esophageal adenocarcinoma esophageal cancer Esophageal Neoplasms gastric cancer gastroesophageal cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breath tests Gastric adenocarcinoma and gastroesophageal junction adenocarcinoma Oesophageal adenocarcinoma Oesophageal cancer Oesophageal cancer nos Oesophageal junction cancer Oesophago-gastric carcinoma Volatile organic compound

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

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