New Total-Body PET scanner could revolutionize vasculitis diagnosis

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria LVV Patients: * ≥18 years of age * Newly diagnosed LVV (based on the 2022 American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR) classification criteria or from a definite diagnosis of LVV on standard of care imaging) * WHO performance status 0-2 * The subject is able and willing to comply with study procedures and signed and dated informed consent is obtained * eGFR of ≥30 (mL/min/1.73m2) within 3 months of \[18F\]FDG injection in subjects who have a history of renal impairment, renal disease, renal transplant or diabetes Exclusion Criteria LVV Patients: * The subject is pregnant or lactating * Participants with claustrophobia or who are unable to comfortably tolerate the scanning procedure * History of allergy to iodinated contrast * Commencement of steroids \> 7 days prior to administration of the radiotracer * Poorly controlled diabetic with a blood glucose \>11mmol/L * Evidence of a significant medical condition or laboratory finding which, in the opinion of the Investigator, makes it undesirable for the patient to participate in the trial. Inclusion Criteria Healthy Volunteers: * Three subjects ≥18 years of age that are also \< 50 years old and three subjects ≥50 years of age * WHO performance status 0-2 * The subject is able and willing to comply with study procedures and signed and dated informed consent is obtained Exclusion Criteria Healthy Volunteers: * The subject is pregnant or lactating * Participants with claustrophobia or who are unable to comfortably tolerate the scanning procedure * Participants with any contra-indication to MRI * Known allergy to gadolinium-based contrast agents * History of smoking * History or current diagnosis of the following medical conditions: * Diabetes Mellitus * Chronic Kidney Disease * Atrial Fibrillation * Migraines * Rheumatoid Arthritis * Systemic Lupus Erythematosus (SLE) * Historic or current prescription of the following medications: * Any blood pressure medication * Any antipsychotic medication * Steroids * Weight of ≥75Kg (in order to keep the radiation dose \<10mSV for HV) * Evidence of any significant medical condition which, in the opinion of the Investigator, makes it undesirable for the HV to participate in the trial * Participants that have undergone any imaging investigation that exposes them to radiation within the previous 12 months