Hidden killers in controlled hypertension: study probes why blood pressure meds aren't enough
NCT ID NCT07187596
First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 3 times
Summary
This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fatal outcomes. The goal is to improve how we manage hypertension and prevent unexpected deaths.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors identify hidden risk factors that cause death even when blood pressure is controlled, leading to better monitoring or treatment strategies.
- What could go wrong
- This is a pooled analysis of existing studies, not a new treatment trial. It may not find clear answers, and results might not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 2,547 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Studies including patients (any age or sex) with: * Interventional treatment for hypertension * Documented blood pressure control (as defined by each primary study) * Reported mortality or fatal outcome
- Ages
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1 minute to 130 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Inclusion: * Human birth in all sex chromosomes. * Study reports evidence of living with owned systemic/arterial hypertension by one of definition following; * Quantitative: Blood pressure number higher over the normal range by each protocol in mmHg unit in any arm of study. * Qualitative: Clarify the underwent both retrospective, observation or intervention of blood pressure and clearly clarify number of hypertension participants in article. * Study design: any type of studies and have a doi number. * In case report type study, the article recruit in only high blood pressure is a burden that reports both direct intervention for blood pressure or indirect intervention such as treatment of vascular damage from high blood pressure. * In a group of literature review type study, the number of hypertension participants with references from both in supplementary document or traced back via each doi number have to clearly declare in that free full-text and currently non-retracted article without personal requirement as raw material to processing the individual participant data meta-analysis * Study recruit only last version of study series that have to confirm published the hypertension participant with mortality outcomes. * English-language studies. * Exclusion: * Non human/human-specimen studies. * Evidence confirms local site or specific system hypertension only such as studies of pulmonary hypertension, portal hypertension, ocular hypertension without clearly defining the number of systemic arterial hypertension in articles. * No report of conclusion of participant such as no mortality report, no failed/successful outcome from last follow up from hypertension associated life-threatening event. * Deaths due to suicide, trauma, or illegal drugs including intend to take medication overdose in any reason. * Book, Testimonial, Interview, Conference, Protocol articles. * Sub-group analysis. * Duplicate one of the doi/nct/prospero numbers. * No doi. Number
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Owned study
Bangkok, Bangkok, 10110, Thailand
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