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Decades-Long study of 121,700 nurses aims to uncover hidden heart disease triggers

NCT ID NCT00005152

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This long-term study follows over 121,000 female nurses to explore how hormones, diet, lifestyle, and genetics affect the risk of heart disease and stroke. Researchers are analyzing blood samples to create a 'metabolomic risk score' that could help predict coronary heart disease. The goal is to better understand what puts women at risk and improve prevention strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify new biomarkers and risk scores to better predict heart disease in women.
What could go wrong
This is an observational study, not a clinical trial of a treatment. It can show associations but cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

121,700 people

The number who actually took part.

Start date

Aug 1980

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

See "Detailed Description"

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

See "Detailed Description"

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Conditions

The condition(s) this trial relates to.

Angina Pectoris cardiovascular disorder coronary artery disorder Coronary Disease diabetes mellitus heart disorder intermediate coronary syndrome myocardial infarction pulmonary embolism stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Angina pectoris Cardiovascular diseases Cerebrovascular accident Coronary disease Diabetes mellitus Heart diseases Menopause Myocardial infarction Postmenopause Pulmonary embolism

More trials for these conditions

Other studies related to the condition(s) this trial covers.