HEART DISEASES

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue with standard med…

This study tests a digital app called VIRTUES that helps people with heart conditions manage their health from home. The app provides personalized recommendations for medications, diet, exercise, and more. Researchers will enroll 2,000 patients to see if the app is easy to use an…

This study tests whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 p…

This study is checking how well two new stents (Synergy XD and Synergy Megatron) work in everyday medical practice for people with coronary artery disease. About 2000 adults getting these stents will be followed to see if they have fewer heart attacks, need repeat procedures, or …

This study compares two heart bypass surgery techniques in women: using one artery (single arterial grafting) versus multiple arteries (multiple arterial grafting) to reroute blood around blocked heart vessels. The goal is to see which method leads to fewer heart problems, stroke…

This study tests a new drug, KPL-387, for people with recurrent pericarditis (repeated heart lining inflammation) that is currently well-controlled with standard treatments. About 80 adults will switch from their usual therapy to KPL-387 alone to see if it prevents flare-ups and …

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with other treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the new pump or an existing one to see if the new …

This study compares two imaging methods for guiding treatment of hardened coronary arteries. About 700 adults with heart disease will either receive CT-guided or standard ultrasound-guided care during stent placement. The goal is to see if the CT approach improves stent expansion…

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein to help the valve close better, aiming to reduce symptoms and hospital stays. Participants are randomly assigned to get th…

This study compares two methods of closing the breastbone after open heart surgery: rigid plates versus traditional wires. It includes 250 adults at high risk for wound problems, such as those with diabetes or obesity. The goal is to see which method leads to better bone healing …

This study tests two methods of giving a contrast dye called Lumason during heart ultrasound. It involves 106 adults whose initial heart ultrasound images were not clear enough. The goal is to see whether a slow drip or a quick injection provides better heart chamber visibility a…

This study is testing whether a new smartphone-based 12-lead ECG device can accurately diagnose heart attacks (STEMI and NSTEMI) compared to standard hospital ECG machines. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to see if the por…

This study tests an experimental drug called acoramidis in 587 adults aged 18–75 who carry a faulty gene that causes transthyretin amyloidosis (ATTR) but have no symptoms yet. The drug aims to stabilize a key protein and prevent or delay the buildup of harmful plaques in the hear…

This early study tests a new device called the A-FLUX Reducer for people with chest pain caused by small heart vessel disease (microvascular dysfunction). The device is placed in a vein near the heart to improve blood flow and reduce symptoms. About 30 adults with persistent ches…

This study looks at whether showing people a live ultrasound of their heart in the emergency room can motivate them to eat better, exercise more, and see a doctor regularly. Adults aged 45 and older with high blood pressure, diabetes, or obesity are eligible. Participants either …

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer surveys through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs or …

This study is a registry that collects information from routine hospital care to confirm that Abbott's heart devices are safe and work as intended. About 2,500 people who receive these devices as part of their normal treatment will be followed. The goal is to meet regulatory requ…

This study is creating a large collection of human biological samples and health information, called a biobank. Researchers will use these materials to study the causes of diseases like cancer, heart disease, and diabetes. Up to 10,000 participants will provide samples and data t…

This study looks at whether giving routine heart ultrasounds to nursing home residents can help catch heart problems early and reduce emergency hospital visits. About 1,050 residents will take part, and researchers will track how well the screening works and if it leads to better…

This study is looking at whether people with psoriasis have a higher risk of heart disease. Researchers will follow 1,000 adults with psoriasis, using heart scans and blood tests to find early warning signs. The goal is to better understand the link between psoriasis and heart pr…

This study follows people aged 12 and older who have a genetic heart condition called PKP2-ACM. Researchers will monitor heart rhythms, biomarkers, and quality of life over time to better understand how the disease naturally progresses. No new treatments are given; participants c…

This study involves 50 people who need a pacemaker or defibrillator. It compares two FDA-approved methods for placing a wire in the Bachmann bundle, a part of the heart that helps coordinate beating. One method uses contrast dye and X-ray, while the other adds an electrocardiogra…

This study is tracking the safety and performance of four specific tools (delivery set, pushers, and sizing balloon) used by doctors during heart implant procedures. About 685 people who receive these tools as part of their heart device implantation will be included. The goal is …

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…

This study tests whether a smartwatch and a digital platform can help doctors spot heart rhythm problems like atrial fibrillation early in people with heart disease. About 520 adults will wear a smartwatch and a standard heart monitor for up to 45 days. The goal is to see if the …

This study is a large registry that will collect information from 8,000 people having heart or chest surgery. The goal is to find out which factors before and during surgery are linked to serious problems after surgery, such as death, shock, or needing another operation. By under…

This study looks at how whole milk versus skim milk affects blood sugar and cholesterol in healthy adults. Researchers will ask 100 participants to drink only whole milk for a period, then switch to skim milk (or the other way around). The goal is to see if the fat content in mil…

This study looks at how well people from underrepresented groups (Black and non-White Hispanic) with heart disease or related conditions can stick with a clinical trial done mostly from home using smartphones. The goal is to find ways to make future trials more inclusive and easi…

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of 140 people with mild blockages. Participants get either statins or a placebo for 3 months, and advanced CT scans track plaque changes. The goal is to understand who…

This study collects DNA samples from 1200 adults receiving routine care at the University of Chicago. Researchers test for genetic differences that could affect how patients respond to certain medications, including risk of side effects. The results are shared with their doctors,…