HEART DISEASES

This study is testing a new heart pump device called the BrioVAD System for people with severe, treatment-resistant heart failure. It will compare the new pump's safety and effectiveness to an existing, widely used pump called the HeartMate 3. The goal is to see if the new device…

This study is testing a new digital app called VIRTUES, designed to help people manage various heart conditions from home. It will enroll 2000 participants across Canada to try seven core modules that give personalized advice on things like blood pressure, cholesterol, and heart …

This study is testing if a new, leadless pacemaker works as well as a standard pacemaker for improving patients' ability to exercise. The new device is much smaller and has no wires, which could mean fewer complications. About 100 patients with a slow heart rate will be randomly …

This study is testing a small implant called the Carillon device for people with heart failure and a leaky mitral valve. The device is placed in a vein near the heart to help the valve close better. Researchers will compare 300 people who get the implant to those who have a simil…

This study aims to find out if using two arteries instead of one during heart bypass surgery leads to better long-term results for women. It will enroll 2,300 women undergoing their first bypass surgery and randomly assign them to receive either the single or double artery techni…

This international study is testing whether using just one blood-thinning medication is as safe and effective as using two after a specific type of heart artery procedure. It focuses on patients aged 75 and older or those at high risk for bleeding. The goal is to find the best ba…

This trial is testing if implanting a mechanical heart pump (HeartMate 3) early can help people with advanced heart failure live longer and have a better quality of life compared to staying on strong medications alone. It will enroll about 850 adults whose heart failure is worsen…

This study aims to see how well two newer heart stents (Synergy XD and Synergy Megatron) work and how safe they are compared to other drug-coated stents already in use. It will follow 2,000 adults with clogged heart arteries in their normal medical care. The main goal is to track…

This study is testing whether using smartwatches and a special digital platform can help doctors monitor heart patients from home. It aims to see if this system can spot irregular heartbeats early and alert doctors quickly. The trial will involve 520 adults with heart conditions,…

This study is testing two different methods to help doctors place a pacemaker wire in a specific area of the heart called the Bachmann bundle. Researchers want to see if using a special dye with x-rays works better than using heart electrical signals with the dye and x-rays for p…

This study is testing a medication called KPL-387 for people with recurrent pericarditis, a painful inflammation around the heart. The main goal is to see if patients can safely switch from their current treatments to KPL-387 alone and stay free of flare-ups. Researchers will fol…

This study is testing whether offering routine heart ultrasound scans to nursing home residents helps catch heart problems early and reduces emergency hospital visits. Researchers will compare nursing homes that offer the scans to those that provide usual care, tracking how many …

This study aims to see if using a special heart CT scan to plan a procedure is as good as or better than the current standard method, which uses an ultrasound probe inside the artery. Researchers will compare the two approaches in 700 patients with hardened, clogged heart arterie…

This study aims to find the best way to give a contrast dye called Lumason during heart ultrasound exams. It will compare giving the dye as a single quick injection versus a slower, continuous drip. The goal is to see which method produces clearer images of the heart's inner wall…

This study is testing if showing adults their own heart images with a bedside ultrasound during an ER visit, along with education, can motivate them to get follow-up care and adopt healthier habits. The goal is to prevent heart failure in people with risk factors like high blood …

This study is testing whether a free phone app called PulsePoint can help save more lives from sudden cardiac arrest. When someone calls 911 for a suspected cardiac arrest in a public place, the app can alert CPR-trained citizens within a short distance so they can start help bef…

This study is testing whether a new drug called acoramidis can prevent or delay heart and nerve damage in people who carry a gene for a serious disease but don't yet have symptoms. About 582 adults aged 18-75 with the genetic risk will receive either the drug or a placebo to see …

This study is collecting real-world data on how well Abbott's heart repair devices work and how safe they are after they're already approved and being used in hospitals. It will follow about 2,500 patients who receive these devices as part of their standard care for various heart…

This study aims to understand why some people with atrial fibrillation (an irregular heartbeat) still have strokes despite taking blood-thinning medication. Researchers will follow 500 patients who have had a stroke and have atrial fibrillation, collecting blood samples and heart…

This study aims to settle a long-standing debate about which type of milk is better for heart health. For four months, 100 adults who regularly drink milk will switch between drinking whole milk and skim milk. Researchers will measure changes in blood sugar, cholesterol, and bloo…

This study aims to understand how to better include Black and Hispanic people in remote heart health research. It will test if using smartphones helps people with conditions like high blood pressure or diabetes stick with a study program. The goal is to learn how to make future m…

This study aims to understand how often people with psoriasis have hidden heart problems and what puts them at risk. Researchers will follow 1,000 adults with psoriasis, checking their blood for specific markers and performing detailed heart scans. The goal is to find early signs…

This study aims to see if data from smartwatches can help detect and understand heart disease risks earlier. About 10,000 adults, including both people with heart conditions and healthy individuals, will wear a provided smartwatch for one year while answering periodic health surv…

This study aims to learn more about how a specific inherited heart condition (PKP2-ACM) progresses over time in people receiving standard care. Researchers will observe 36 patients who have this genetic variant and an implanted heart device, collecting data on their heart health,…

This study aims to monitor the safety and performance of four specialized medical tools used by doctors when implanting heart devices. It will enroll about 685 patients who have already undergone these procedures. Doctors will complete surveys about how well the tools worked and …

This study is testing whether genetic information can help doctors choose safer and more effective medications for their patients. Researchers will collect DNA samples from 1,200 adults receiving routine care at the University of Chicago Medical Center. They will track whether do…

This study aims to understand if a short, 3-month course of high-dose cholesterol medication (statin) can change the fatty buildup (plaque) in heart arteries, as seen on special heart scans. Researchers will follow 140 patients with chest pain but no prior statin use for 24 month…