HEART DISEASES

This study compares a new leadless pacemaker (Micra AV) to a traditional pacemaker with wires in 100 adults aged 70 or older who need a pacemaker for a slow heartbeat. The goal is to see if the leadless version helps people exercise as well as the standard one. Participants are r…

This study tests a device called the Supira System, which temporarily helps the heart pump blood during high-risk procedures for blocked arteries. About 71 adults with heart disease will receive this support to see if it safely prevents dangerously low blood pressure. The goal is…

This study tests a new device called the PULSTA valve, which is placed inside the heart through a tube in a blood vessel, avoiding open-heart surgery. It is for people with a damaged pulmonary valve that either leaks or is too narrow. The study includes 58 patients and checks if …

This study compares two drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in three heart arteries. Participants receive modern heart care including imaging and medications. The goal is to see which stent is safer and more effective at pre…

This study tests whether using an insertable heart monitor to guide early treatment can reduce the amount of time people spend in atrial fibrillation (AFib) after a catheter ablation procedure. About 120 adults with AFib will receive the monitor and be followed for 15 months. The…

This study tested whether a risk score based on health records can help find people with hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. About 1,955 adults aged 30 and older with certain risk factors used a remote ECG monitor at home. The g…

This study tests whether a nerve block given before heart surgery can help manage pain and reduce the need for strong painkillers like opioids. About 150 adults having certain heart surgeries will be randomly assigned to receive one of two types of numbing medicine. The goal is t…

This study looks at whether older adults (65+) with a specific type of heart disease (TTR cardiac amyloidosis) feel better when they stop taking beta-blockers, a common heart medication. Twenty participants will go through two periods—one on the drug and one off—to compare exerci…

This study examines how a specific gene variation (CYP2C19) influences the long-term risk of major heart problems, strokes, and limb complications in people with blood vessel disease. Researchers will analyze data from 13,000 patients who have already had genetic testing. The goa…

This study explores whether changing how people connect online can help improve COVID-19 vaccine attitudes and uptake among African American and other underserved groups. About 4,500 adults in the U.S. with internet access are taking part. Researchers are testing if reducing onli…

This study watches over 800 heart failure patients in Germany who are starting dapagliflozin, a drug recently approved for heart failure. Researchers will track how long patients stay on the drug, any side effects, and changes in symptoms and quality of life. The goal is to see h…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyle and health changes affect heart disease risk later in life. Researchers measure things like blood pressure, weight, and cholesterol over time. The goal is to understand what…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor can also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. However, the study was withdrawn before enr…

This long-term study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers used medical records and exams to identify risks and triggers. The goal was to better understand how to prevent these con…

This study tests a personalized approach called N-of-1 trials to help older adults (65+) with a type of heart failure (HFpEF) decide whether to continue or stop taking beta-blockers. Each participant serves as their own experiment, alternating between taking the drug and a placeb…

This study tests whether a smartphone app called PulsePoint can increase the number of people who receive CPR or a defibrillator from a bystander before emergency services arrive. About 340 adults who suffer a sudden cardiac arrest in a public place will be included. Half of the …

This study looks at how bacteria from dental treatment can help find better ways to detect sepsis, a life-threatening condition. Researchers are studying 100 people with gum disease to see how bacteria enter the blood and affect the body. The goal is to develop tests that spot se…

This study tests whether a phone app called StudyU can help people with heart failure reach the right dose of their beta blocker medicine. Five adults aged 65 and older with heart failure will use the app to track their progress. The goal is to see if the app is practical and acc…

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass) plus medications, versus medications alone. Researchers want to see if one strategy leads to fewer …

This study involves about 2,400 rural adults in New York and Texas. Participants will join a civic engagement program where they identify local barriers to healthy eating and physical activity, then create community projects to address them. The goal is to see if this approach im…

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study tests whether giving doctors a special risk score—one that combines a person's genes with things like cholesterol and age—helps them make better decisions to prevent heart disease. About 1,000 people at moderate risk for heart disease but who have never had a heart att…

This study follows over 6,000 people over many years to see if traits like hostility and other emotional factors are linked to heart disease. Researchers are observing participants without giving any treatment. The goal is to better understand what leads to heart problems, not to…