HEART DISEASES

This study tested a device called the preCARDIA System to see if it could safely help people with severe, worsening heart failure. The device temporarily blocks a major vein in the chest to help the body remove excess fluid when standard medications aren't working well enough. Th…

This study tested whether providing 12 weeks of specially designed, healthy meals could improve the diets and health of people with heart failure. Researchers enrolled 60 adults in California and gave them either 14 or 15 medically tailored meals per week. They measured changes i…

This study tested a very small balloon catheter called Sapphire 3. Doctors used it to gently open long-term, completely blocked heart arteries before placing a stent. Researchers watched 170 patients to see if the device was safe and worked well during the procedure and for 24 ho…

This large study aimed to see if taking two blood-thinning medications (clopidogrel plus aspirin) is better than taking aspirin alone for patients with multi-vessel heart disease who have received a stent. It involved 8,250 patients across 100 centers and followed them for at lea…

This study tested whether giving the common heart medication metoprolol right after surgery and for a few days in the hospital could reduce heart-related injuries in patients with coronary artery disease. It involved 72 patients who were not already taking similar medications. Pa…

This study tested a replacement heart valve for people born with heart defects that cause a leaky or narrowed pulmonary valve. The goal was to see if the new valve was safe and effective at improving blood flow from the heart to the lungs. It involved 57 participants who had a pr…

This completed Phase 2 trial tested whether the experimental drug tovinontrine could help control heart failure in patients whose hearts pump normally but still struggle. The study involved 303 adults with chronic heart failure symptoms who received either the drug or a placebo f…

This study tested whether a new drug called tovinontrine could help control chronic heart failure. It involved 557 adults with a weakened heart pump who were already on standard treatments. Researchers compared the drug to a placebo over 12 weeks, looking at changes in key blood …

This study tested a new automatic tool on a pocket-sized ultrasound device to see if it could reliably measure how well the heart pumps blood. Researchers compared this tool's measurements against the standard visual method used by doctors in emergency rooms. The goal was to see …

This study tested a culturally tailored program designed to help African American women manage stress, improve nutrition, and increase physical activity to reduce their risk of heart disease, stroke, and diabetes. 175 women participated in this completed trial. The program focuse…

This study aimed to understand how a typical Western diet (high in fat and sugar) triggers early changes in immune cells that may lead to heart disease. Eight healthy, normal-weight adults ate a carefully controlled, high-calorie diet for 8 weeks. Researchers analyzed their blood…

This study looked at how eating different types of dairy—full-fat versus fat-free milk and yogurt—changes the bacteria in your gut and might affect your risk for heart disease. Thirty-seven adults over 50 tried each type of dairy for three weeks while researchers collected blood …

This study aimed to find out if silent, painless episodes of reduced blood flow to the heart (silent ischemia) could predict future heart problems like heart attacks or death in people who already had coronary heart disease. Researchers followed 973 patients for one to three year…

This research study aimed to understand if viruses in pregnant women, especially those with diabetes, might increase the risk of heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to look for viruses and the body's immune response to them. …

This study aimed to find out if certain genetic variations increase a person's risk of sudden cardiac death, even if they appear healthy. Researchers analyzed blood samples and health records from over 100,000 people in large national studies to look for these genetic links. The …