HEART DISEASES

This study tested a drug called tovinontrine in 303 adults with chronic heart failure where the heart pumps normally but is stiff. The goal was to see if the drug lowers a key heart stress marker (NT-proBNP) compared to a placebo over 12 weeks. Participants had symptoms like shor…

This study tested whether taking two blood pressure medicines together works better than taking just one for people with heart disease caused by high blood pressure. 118 adults aged 18-70 took either a combination of valsartan and hydrochlorothiazide or valsartan alone for 8 week…

This study tested whether giving metoprolol, an FDA-approved beta-blocker, right after surgery and during hospital recovery can reduce heart damage in people with coronary artery disease. Researchers monitored daily blood tests for heart injury markers in 72 patients aged 50 and …

This study tested a device called preCARDIA in 60 people with severe, worsening heart failure. The device temporarily blocks a large vein in the chest to help the heart pump better. The main goal was to see if the device is safe and works as intended.

This study tested a culturally-tailored program that combines nutrition, exercise, and stress management to help African American women improve their heart health. 175 women with risk factors like high blood pressure or prediabetes took part. The goal was to see if the program co…

This study tested a very small balloon catheter (0.85-1.25 mm) in 170 people with completely blocked heart arteries (chronic total occlusion). The balloon was used to open the blockage before placing a stent. Researchers checked if the balloon could be safely delivered, inflated,…

This study tested a new heart valve (SAPIEN XT) in 57 people whose surgically-placed valve or tube between the heart and lungs was not working properly. The goal was to see if the valve could safely reduce leakage or blockage without needing another open-heart surgery. The study …

This study tested a new drug called tovinontrine in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if the drug could safely lower a key heart stress marker (NT-proBNP) compared to a placebo over 12 weeks. Participants had heart failure symp…

This study looked at whether taking two blood thinners (clopidogrel and aspirin) for a longer time after getting a heart stent helps prevent future heart attacks, strokes, or death in people with multiple blocked heart arteries. About 8,250 adults aged 18-75 who already had a ste…

This study tested a new automatic tool in a small, portable ultrasound device to measure how well the heart pumps blood (ejection fraction). The goal was to see if this tool gives more consistent results than the usual visual method used in emergency rooms. About 60 adults with s…

This study looked at whether providing medically tailored meals for 12 weeks could improve the diet quality of people with heart failure. Sixty participants from California took part. The main goal was to measure changes in their eating habits using a standard healthy eating scor…

This study compared the effects of full-fat and fat-free milk and yogurt on gut bacteria and heart disease risk. Researchers enrolled 37 adults over age 50 who were overweight but otherwise healthy. Participants consumed different dairy products, and the team measured changes in …

This study looked at whether viral infections in pregnant women with diabetes might increase the chance of their babies being born with heart defects. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather initia…

This study aimed to find out if silent myocardial ischemia—a condition where the heart doesn't get enough blood without causing chest pain—raises the risk of heart-related death or problems in people with coronary heart disease. Researchers followed patients for one to three year…

This study looked at how eating a typical Western diet (high in saturated fat, fructose, and calories) for 8 weeks affects immune cells called monocytes in healthy, normal-weight adults aged 20-45. Researchers measured changes in a protein linked to inflammation and heart disease…

This study looked at whether certain gene changes make sudden cardiac death more likely. Researchers checked DNA from 2500 people for links to heart rhythm problems. The goal was to find genetic clues that could help predict risk, not to test a treatment.