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Heart bypass showdown: does using more arteries save lives?

NCT ID NCT03217006

Disease control Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 21, 2026 · Updated 3 times

Summary

This trial tests whether using two or more arterial grafts during heart bypass surgery is better than using just one. About 4,300 patients will be randomly assigned to receive either a single arterial graft or multiple arterial grafts. The goal is to see if multiple grafts reduce the chance of death, stroke, heart attack, or the need for repeat procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
arterial grafts (blood vessels used in heart bypass surgery)
What this could lead to
If it works, this could show that using more arterial grafts during bypass surgery lowers the risk of death, stroke, or needing another procedure.
What could go wrong
This is a large trial, but results may not apply to older patients or those with weaker hearts. Risks include bleeding, infection, and stroke from surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 4,300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2018

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Primary isolated CABG patients with disease of the left main coronary artery and/or of the left anterior descending and the circumflex coronary system with or without disease of the right coronary artery. Exclusion Criteria: * Age \> 70 years * Single graft * Emergency operation * Evolving myocardial infarction within 48 hours of surgery * Left ventricular ejection fraction of \< 35% * Any concomitant cardiac or non-cardiac procedure * Previous cardiac surgery * Preoperative severe end-organ dysfunction (dialysis, liver failure, respiratory failure), cancer or any co-morbidity that reduce life expectancy to less than 5 years. * Inability to use the saphenous vein or to use both radial and right internal thoracic arteries * Anticipated need for coronary thrombo-endarterectomy * Planned hybrid revascularization

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Conditions

The condition(s) this trial relates to.

coronary artery disorder heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease Heart diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    59 sites in 17 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Allegheny General Hospital (Cardiovascular Institute)

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • Anthea Hospital

    RECRUITING

    Bari, Italy

  • Baystate Health

    RECRUITING

    Springfield, Massachusetts, 01109, United States

  • Centro Hospitalar e Universitário São João

    RECRUITING

    Porto, Portugal

  • Cleveland Clinic Foundation

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • Dedinje Cardiovascular Institute

    RECRUITING

    Belgrade, Serbia

  • Duisburg Heart Center

    RECRUITING

    Duisburg, Germany

  • Düsseldorf University

    RECRUITING

    Düsseldorf, Germany

  • Essen University

    RECRUITING

    Duisburg, Germany

  • European Hospital

    RECRUITING

    Rome, Italy

  • Federal University of Sao Paulo

    RECRUITING

    São Paulo, Brazil

  • Fondazione Poliambulanza

    RECRUITING

    Brescia, Italy

  • Fuwai Hospital

    RECRUITING

    Beijing, China

  • General University Hospital, Prague

    RECRUITING

    Prague, Czechia

  • Giessen Hospital

    RECRUITING

    Giessen, Germany

  • HDZ NRW Bad

    RECRUITING

    Oeynhausen, Germany

  • Hamilton General Hospital

    RECRUITING

    Hamilton, Canada

  • Heart Center (Herzzentrum)

    RECRUITING

    Leipzig, Germany

  • Hospital Clinic de Barcelona (ICCV)

    RECRUITING

    Barcelona, Spain

  • Hospital Univeritario Del Vinalopo

    RECRUITING

    Alicante, Spain

  • Hospitalar de Lisboa Central

    RECRUITING

    Capuchos, Portugal

  • Icahn School of Medicine, Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

  • Innsbruck (Medical University) Austria

    RECRUITING

    Innsbruck, Austria

  • Jena University Hospital

    RECRUITING

    Jena, Germany

  • Jilin Heart Hospital

    RECRUITING

    Changchun, China

  • Krankenhaus Nord Vienna North Hospital

    RECRUITING

    Vienna, Austria

  • Krankenhaus der Barmherzigen Brüder Trier

    RECRUITING

    Trier, Germany

  • Lenox Hill Hospital (Northwell)

    RECRUITING

    New York, New York, 10075, United States

  • London Health Sciences Ontario Canada

    RECRUITING

    London, Canada

  • MU Vienna Austria

    RECRUITING

    Vienna, Austria

  • MUMC Maastricht (University Medical Centre)

    RECRUITING

    Maastricht, Netherlands

  • Maria Cecilia Hospital GVM

    RECRUITING

    Cotignola, Italy

  • Medical University of Silesia (Katowice)

    RECRUITING

    Katowice, Poland

  • National Taiwan University Hospital

    RECRUITING

    Taiwan, China

  • National University of Singapore

    RECRUITING

    Singapore, Singapore

  • Nebraska Heart Hospital

    RECRUITING

    Lincoln, Nebraska, 68526, United States

  • NewYork-Presbyterian Brooklyn Methodist Hospital

    RECRUITING

    Brooklyn, New York, 11215, United States

  • NewYork-Presbyterian Queens

    RECRUITING

    New York, New York, 11355, United States

  • Ospedale Le Molinette

    RECRUITING

    Torino, Italy

  • Robert-Bosch-Hospital

    RECRUITING

    Stuttgart, Germany

  • Royal Victoria Hospital (McGill)

    RECRUITING

    Québec, Canada

  • Ruijin Hospital Shanghai Jiao Tong University School of Medicine

    RECRUITING

    Shanghai, China

  • Saitama Medical University

    RECRUITING

    Saitama, Japan

  • Severance Cardiovascular Hospital, Yonsei University College of Medicine

    RECRUITING

    Sinchŏn-dong, South Korea

  • St. Boniface General Hospital / WHRA

    RECRUITING

    Winnipeg, Canada

  • Sunnybrook Health Sciences Centre

    RECRUITING

    Toronto, Canada

  • Teda Hospital (TICH)

    RECRUITING

    Tianjin, China

  • Toronto General Hospital

    RECRUITING

    Toronto, Canada

  • Universita' Cattolica del Sacro Cuore

    RECRUITING

    Roma, Italy

  • Universite Laval Quebec (CRIUCPQ) Canada

    RECRUITING

    Québec, Canada

  • University Hospital (Praceta Mota Pinto)

    RECRUITING

    Coimbra, Portugal

  • University Hospital Dubrava

    RECRUITING

    Zagreb, Croatia

  • University Hospital Erlangen

    RECRUITING

    Erlangen, Germany

  • University Hospital of Montreal (CHUM)

    RECRUITING

    Montreal, Canada

  • University Medical Center of Goettingen

    ENROLLING_BY_INVITATION

    Göttingen, Germany

  • University of Colorado

    RECRUITING

    Boulder, Colorado, 80309, United States

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

  • University of Ottawa Heart Institute Canada

    RECRUITING

    Ottawa, Canada

  • Weil Cornell Medical College Department of Cardiothoracic Surgery

    RECRUITING

    New York, New York, 10065, United States

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