CARDIOVASCULAR DISEASES

This study tests whether using a portable air cleaner at home can improve heart health in older adults (ages 55-79) living in Montana, an area with worsening wildfire smoke. Participants will use the device for a period, and researchers will measure changes in their heart disease…

This study tests a device called TricValve for people with severe tricuspid regurgitation, a condition where a heart valve leaks blood backward. About 780 adults will receive either the device plus standard care or standard care alone. The goal is to see if the device reduces blo…

This study tests a new biodegradable device to close a common heart hole called PFO in people who have already had a stroke or mini-stroke. About 258 adults aged 18-65 will get the device or a standard treatment. The goal is to see if the device safely seals the hole and prevents…

This study compares two cholesterol-lowering approaches in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate statin plus ezetimibe, the other a high-dose statin alone. The goal is to see which strategy better prevents majo…

This study looks at whether adding vitamin C, omega-3s, lignin, and lactulose to standard care can improve recovery in 108 adults after heart bypass surgery. Participants take the supplements daily for 10 weeks starting two weeks after surgery. The goal is to see if this combinat…

This study tests a device that uses radiofrequency energy to calm overactive nerves in the lung arteries of people with heart failure and a specific type of high blood pressure in the lungs. About 750 adults who are stable on heart failure medications will either get the procedur…

This study looks at 318 women who had pregnancy complications like preeclampsia or gestational diabetes. Half will get detailed images of their blood vessels to motivate healthier habits, while the other half gets standard care. The goal is to see if this visual feedback lowers h…

This study will follow 2,725 women aged 45-75 to see if newer forms of hormone replacement therapy (like creams, gels, and sprays) affect their risk of heart disease. The researchers want to find out if these modern treatments are safer for the heart than older methods. Participa…

This study compares a new device called Freesolve, a temporary magnesium scaffold that dissolves over time, to a standard permanent metal stent for treating blocked heart arteries. About 1,859 people with coronary artery disease will be enrolled to see if the dissolving scaffold …

This study tests whether a dietary supplement called propionic acid (a substance made by gut bacteria) can improve blood vessel function in 20 people with coronary artery disease. Participants will take the supplement for 4 weeks, and researchers will measure changes in artery he…

This study tests Mobili®, a portable digital dispenser that gives the right pills at the right time, to help people with multiple chronic diseases stick to their medication schedule. About 96 adults with diabetes or heart disease who take at least two daily oral medications will …

This study tests whether vericiguat, a drug that boosts a natural signaling molecule called cGMP, can improve how the body uses energy and responds to insulin. It involves 200 Black adults with obesity and insulin resistance. Over 12 weeks, participants will receive either verici…

This study tests a new mobile app designed to help bank employees in Pakistan who sit for long hours become more active and eat healthier. The app provides reminders and tips to take breaks, exercise, and eat fruits and vegetables. Researchers will check if the app is easy to use…

This study tests whether dapagliflozin, a drug used for diabetes, can improve exercise ability and heart function in people who have had the Fontan procedure for a single-ventricle heart condition. About 30 adolescents and adults will take the drug daily for 3 months. The main go…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. About 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will check changes in anxiety, mood, and heart measures like he…

This study looks at whether semaglutide and tirzepatide (drugs used for weight loss and diabetes) directly affect blood vessels and heart function, beyond just helping people lose weight. Researchers will give these drugs to 112 volunteers with different body weights and blood pr…

This study follows 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to multiple chronic conditions such as diabetes, heart disease, and metabolic syndrome. Participants will have regular health checks, blood and urine te…

This study collects basic health information like blood pressure, heart rhythm, and heart rate from 50 adults aged 18 to 64. The goal is to use this data to create a device that can monitor blood pressure continuously without needles or cuffs. Participants will have their vitals …

This study will follow about 6,000 Italian adults who are prescribed inclisiran, evolocumab, or alirocumab—medicines that lower cholesterol. Researchers want to see how consistently patients take these drugs over months and years in everyday life, not in a controlled clinic. The …

This study looks at how to help VA medical centers better serve women Veterans, especially those in midlife. Researchers will test two different strategies to get more women involved in programs for heart health, weight management, and stress. The study involves 18 VA sites and f…

This study looks at how the loss of estrogen after menopause might increase the risk of heart disease. Researchers will measure blood pressure, nerve activity, and signs of inflammation in 20 healthy postmenopausal women. The goal is to understand the link between estrogen defici…

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are connected in older adults with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect h…

This study looks at whether the supplement quercetin can improve how small blood vessels function in people with obesity. Forty adults aged 18-40 with a BMI over 30 will take quercetin and have their blood vessel health measured using cameras and small sensors placed on the skin.…

This pilot study will test whether a heart health education program designed specifically for women can improve their knowledge, quality of life, and healthy habits. About 50 women with heart disease who are already in cardiac rehab will either get the special program plus usual …

This study looks at 40 mothers and their babies to see if mindfulness training during pregnancy helps them handle stress better together. Researchers will measure heart rate and breathing patterns during a lab stress task when babies are 6 months old. They want to know if better …

This study will follow 300 people with stage 4 chronic kidney disease (not yet on dialysis) for 18 months. Researchers want to see if high levels of lipoprotein(a) — a type of fat in the blood — are linked to future heart attacks, strokes, or the need for dialysis. The goal is to…

This study observes 30 adults with dilated cardiomyopathy (a weakened heart muscle) caused by changes in the BAG3 gene. Researchers will track heart function, symptoms, and health outcomes over time to better understand how the disease progresses. No treatment is given—the goal i…

This study tests whether using a non-invasive electrocardiographic monitor can allow patients with heart rhythm problems after TAVI valve replacement to be discharged early safely. About 100 adults who had a successful TAVI and have certain conduction disorders will be monitored.…

This study looks at whether the cancer drugs zanubrutinib or acalabrutinib are more likely to cause a heart rhythm problem called atrial fibrillation. Researchers will analyze health records from 15,000 adults with chronic B-cell cancers. The goal is to help doctors choose the sa…

This study will test a new screening program to find 50-year-olds in Italy who are at risk for type 2 diabetes and heart disease but haven't been diagnosed yet. About 3,000 people will be invited for a check-up using simple questionnaires. Based on their risk scores, they'll get …

This study aims to test new MRI methods that can see tiny changes in heart muscle structure, which may help detect heart disease earlier than current tests. Researchers at the Cleveland Clinic will compare these advanced scans with standard blood tests and imaging in 1000 adults …

This study will follow one million adults aged 30-74 in Hubei, China, for up to 10 years. Researchers will collect health data and Traditional Chinese Medicine (TCM) body types to see how they relate to chronic diseases like heart disease, cancer, and diabetes. The goal is to cre…