CARDIOVASCULAR DISEASES

This study is testing whether drinking a specific brand of no-sugar-added soymilk daily can help lower cholesterol levels in adults. It will enroll 50 healthy adults aged 18-65 who have high total cholesterol. Participants will drink two bottles of soymilk every day for 8 weeks w…

This study is testing whether a drug called vericiguat can improve heart and metabolic health in Black adults with obesity and insulin resistance. Researchers will enroll 200 participants to take either the drug or a placebo pill daily for 12 weeks. The main goals are to see if t…

This study aims to see if patients who have a new aortic valve implanted (TAVI) and develop a specific heart rhythm issue can safely go home from the hospital sooner. They will use a remote heart monitor at home instead of staying in the hospital for observation. The goal is to c…

This study is testing a catheter-based procedure called pulmonary artery denervation (PADN) for people with heart failure and high blood pressure in their lungs. It aims to see if adding this procedure to standard heart failure medications is safer and more effective at preventin…

This study aims to see if a new type of heart stent called Freesolve is as safe and effective as a standard metal stent (Xience). Freesolve is made of magnesium and is designed to dissolve in the artery over time. The study will involve about 1,859 adults with clogged heart arter…

This study is testing whether a dietary supplement called propionic acid can improve blood vessel function in people with coronary artery disease. Researchers want to see if this gut-derived acid reduces inflammation and helps blood vessels work better. The study will enroll 20 p…

This study is testing a 9-month support program to help new mothers improve their heart health after a first pregnancy complicated by preeclampsia. The program uses a special smartphone app for tracking blood pressure and weight, along with online coaching and group meetings. Res…

This study is testing if a drug called dapagliflozin can help people who have had a Fontan heart surgery. It aims to see if the drug improves their ability to exercise and their heart function over three months. The trial will involve about 30 adolescents and adults in Hong Kong …

This study is testing a portable, automated pill dispenser called Mobili® to see if it helps people with diabetes or heart disease take their multiple medications correctly. The device alerts patients when it's time for a dose and can alert a pharmacist if a dose is missed. Resea…

This study is testing a new device made from a material that dissolves over time. It is designed to permanently close a small, common hole in the heart (PFO) that can allow blood clots to pass and cause a stroke. Researchers will compare this new biodegradable device to the stand…

This study is testing whether quercetin, a natural supplement, can help protect and improve the function of tiny blood vessels in people with obesity. Researchers will enroll 40 obese adults aged 18-40 and measure their blood vessel responses before and after taking the supplemen…

This study aims to compare how two different drugs, vicadrostat and spironolactone, affect kidney function and proteins in the blood and urine of people who have both chronic kidney disease and heart disease or heart failure. About 100 participants will take one of the drugs alon…

This study will follow 2,725 menopausal women for 10 years to see if newer forms of hormone replacement therapy (like creams, gels, or sprays) affect their risk of heart attacks, strokes, and other major heart problems. It focuses on women aged 45-75 who already have heart diseas…

This VA program aims to help clinics better provide proven health services for women Veterans in midlife. It will test two different support strategies across at least 18 VA facilities to help them offer trauma-informed care, menopause symptom therapy, and weight management progr…

This study is testing whether showing women pictures of plaque in their arteries helps them make healthier choices to prevent high blood pressure after pregnancy. Researchers will compare two groups of women who had difficult pregnancies: one group gets to see detailed images of …

This study aims to see if mindfulness training for pregnant women can help reduce stress for both mother and baby. Researchers will measure how 40 mother-baby pairs respond to stress at 6 months old and check markers of heart disease risk at 12 months. The goal is to understand i…

This study is testing a new mobile phone app designed to help bank employees in Pakistan improve their health and prevent heart disease. For 12 weeks, one group will use the app for reminders and tips to move more and eat healthier, while another group gets basic printed health i…

This study tests whether a special educational program can help women with heart disease improve their sexual function and overall well-being during cardiac rehabilitation. The program involves group sessions led by a nurse that address safety, emotional concerns, and practical a…

This study is testing whether a dietary supplement called Neurofast can help reduce anxiety and improve heart-related measurements in adults. Over 12 weeks, 80 participants with anxiety symptoms will either take the supplement or receive no extra treatment. Researchers will track…

This early study is testing a small, self-expanding device called the A-FLUX Reducer. It is implanted in a vein near the heart to see if it can safely reduce chest pain in people with coronary microvascular dysfunction, a condition where tiny heart vessels don't work properly. Th…

This study aims to understand how sleep problems and changes in the body's automatic nervous system are connected in older adults with heart disease. Researchers will observe 210 patients aged 65 and over to identify common risk factors and see how these issues might affect heart…

This study aims to understand if a specific blood marker called lipoprotein A (Lp(a)) can help predict heart problems in people with advanced chronic kidney disease (CKD). Researchers will follow 300 patients with stage 4 CKD for 18 months to see if high Lp(a) levels are linked t…

This study aims to understand which of two similar cancer drugs carries a higher risk of causing an irregular heartbeat called atrial fibrillation. Researchers will analyze health records from 15,000 adults with chronic blood cancers who have taken either zanubrutinib or acalabru…

This early research study aims to understand how low estrogen levels after menopause might increase a woman's risk for heart disease. Researchers will measure blood pressure, nerve activity, and inflammation markers in 20 healthy postmenopausal women. The goal is to gather basic …

This study aims to learn how a specific inherited form of heart muscle disease (dilated cardiomyopathy) progresses over time in adults who have a harmful change in their BAG3 gene. Researchers will follow about 30 patients to document their symptoms, heart function, and quality o…

This study is testing a new health screening program to find people at risk for type 2 diabetes and heart disease before they develop symptoms. It will invite 3,000 healthy 50-year-olds in an Italian province to answer health questions and get simple tests. The goal is to see if …

This study will follow one million adults in China for up to 10 years to learn how Traditional Chinese Medicine (TCM) concepts of body types relate to the development of modern chronic diseases like heart disease, cancer, and diabetes. It is an observational study, meaning resear…

This study aims to understand how two weight-loss medications, semaglutide and tirzepatide, directly affect the heart and blood vessels, beyond just helping people lose weight. Researchers will recruit 112 adults, including people with normal weight, obesity, and obesity with hig…

This study aims to test and validate new, faster heart MRI scanning techniques that can detect very early tissue damage. Researchers will compare these detailed heart images with standard blood tests in 1,000 participants, including both people with various heart conditions and h…

This study aims to understand the relationship between urinary function (like bladder control and flow) and the development of other common age-related health problems, such as diabetes, heart disease, and high blood pressure. It will follow 500 Beijing residents aged 60 and olde…