Could a simple supplement fix heart artery damage?
NCT ID NCT05135702
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether taking propionic acid (a natural substance made by gut bacteria) can improve blood vessel function and reduce inflammation in 20 adults with coronary artery disease. Participants will take the supplement for 4 weeks, and researchers will measure changes in artery health, blood markers, and gut bacteria. The goal is to find a new way to manage heart disease, not to cure it.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2027
An estimate. Start dates often move.
- Expected to finish
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Dec 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: History of known coronary artery disease as defined by having one or more of the following: * history of myocardial infarction * angiogram demonstrative \>=50% stenosis in at least 1 major epicardial coronary artery * a previous stress test that showed evidence of ischemia (that has not been revealed to be a false positive test by angiography) * CT coronary study showing EITHER a coronary artery calcium (CAC) score of \>400, OR a description of "significant stenosis" of one or more epicardial arteries. Exclusion Criteria: 1. Unstable angina or myocardial infarction by history, ECG, and/or enzymatic criteria within 1 month of enrollment. 2. LV dysfunction as defined by an LV ejection fraction documented as \< 45% within 1 year of enrollment by an echocardiogram, MRI, or nuclear imaging. 3. Uncontrolled hypertension with a blood pressure greater than 170/100 mmHg at the screening visit. 4. Known history of chronic renal insufficiency, liver dysfunction, or cancer besides non-melanoma skin carcinomas or localized prostate cancer requiring systemic treatment within five years of enrollment. 5. Known history of cognitive impairment or inability to follow study procedures. 6. Patient with GI tract illness such as short gut syndrome, inflammatory bowel disease, or an ileostomy. 7. Patient with an implanted defibrillator or permanent pacemaker on which the potential participant is known to rely upon for greater than 50% of ventricular depolarizations. 8. Patients who received probiotics, prebiotics, or short chain fatty acid supplements (e.g. propionate, butyrate, acetate-containing supplements) within the past 4 weeks. 9. Patients who received antibiotics in the last 12 weeks. 10. Patients with dosing changes of vasoactive medications and HMG-CoA reductase inhibitors in the 6 weeks prior to enrollment. 11. Pregnancy 12. Those who are daily drinkers or use illicit drugs.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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