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New genomic risk model aims to make personalized prevention accessible to all

NCT ID NCT06278883

Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a program called GRACE that helps primary care patients assess their risk for diseases like heart disease, cancer, and liver disease using family health history. Researchers enrolled 245 patients from five clinics, including low-resource settings, to see how many completed the risk assessment and followed up on genetic counseling or testing. The goal is to make genomic medicine more accessible and reduce health disparities.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Disease Risk Assessment (behavioral intervention using family health history and genetic testing recommendations)
What this could lead to
If successful, this model could help more people in low-resource settings get personalized risk assessments for diseases like heart disease and cancer, potentially leading to earlier detection and prevention.
What could go wrong
This is a completed implementation study, not a treatment trial. It measures how well the risk assessment works in practice, not whether it directly improves health outcomes. Results may vary across different clinics and populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

245 people

The number who actually took part.

Started

Jun 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Receiving primary medical care in one of the 5 participating clinics * Age 18 years or older * Able to read and communicate in English * Able to provide written and verbal informed consent * Willing to use the Internet Exclusion Criteria: * Anyone not meeting inclusion criteria * Previous genetic counseling and/or previous hereditary panel testing

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Conditions

The condition(s) this trial relates to.

cancer cardiovascular disorder Hyperthermia liver disorder neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer Cardiovascular diseases Hyperthermia Liver diseases

Contacts and locations

Locations

  • UF Health Augustine Oaks

    Jacksonville, Florida, 32258, United States

  • UF Health Family Medicine - Commonwealth

    Jacksonville, Florida, 32254, United States

  • UF Health Family Medicine - Lem Turner

    Jacksonville, Florida, 32208, United States

  • UF Health Oakleaf

    Orange Park, Florida, 32065, United States

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