School nurses take on heart disease: 6,000 kids in prevention trial
NCT ID NCT06720272
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial tests whether placing trained nurses in schools can prevent rheumatic heart disease in children aged 5 to 16 in Nepal and Zambia. The nurses will teach about the disease, check for strep throat, and help kids get antibiotics. The study will measure if this approach lowers the number of children with heart damage from untreated strep infections.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- school-nurse program (education, screening, and antibiotic access)
- What this could lead to
- If successful, this program could become a low-cost way to prevent rheumatic heart disease in children living in high-risk areas.
- What could go wrong
- This is a large trial, but results depend on real-world school implementation. The program may not reduce disease as much as hoped, and long-term follow-up is needed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 6,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2024
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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5 to 16 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: \- Children aged 5-16 years Exclusion Criteria: * Children / primary caregivers not providing informed consent to participate * Children not attending one of the selected schools
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites in 2 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Centre of Infectious Disease Research
RECRUITINGLusaka, Zambia
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National Academy od Medical Sciences
RECRUITINGKathmandu, Nepal
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can two existing drugs stop rheumatic fever from scarring young hearts?
- A simple antibiotic may shield children from heart disease
- Can yearly heart scans catch rheumatic disease early in children?
- Community health workers may boost antibiotic adherence for rheumatic heart disease
- Study tests simple support for kids with heart disease