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Heart surgery fluid showdown: which priming solution works best?

NCT ID NCT07267546

Knowledge-focused Sponsor: Region Skane Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how different fluids used to fill the heart-lung machine before heart surgery affect the body's balance. 80 adults having bypass or valve surgery will be split into four groups, each receiving a different priming solution. Researchers will track changes in acid-base balance, electrolytes, and kidney function to find the safest option.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ringer's Acetate and Plasmalyte (priming solutions)
What this could lead to
If successful, this could help doctors choose the best priming fluid to reduce side effects during heart surgery.
What could go wrong
This is a small, early-stage study with only 80 participants, so results may not apply to all patients. It is not testing a new treatment, only comparing existing fluids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients 18 years and above * Undergoing coronary artery bypass graft (CABG) surgery as single surgery * Undergoing aortic valve replacement (AVR) as single surgery (AtriClip is allowed) * Given consent to participate, both verbal and written Exclusion Criteria: * Subnormal heart function (defined as an ejection fraction \<45%), and no signs of heart failure (edema). * Body weight \<60 kg or \>120 kg * Preoperative hemoglobin \<120 g/L, * Subnormal kidney function (defined as GFR \<30 ml/min), * Blood sodium outside normal range (135-145 mmol/l), * Need of acute surgery * AVR due to aortic valve insufficiency * Changes in operating method or addition of intraoperative procedures.

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Conditions

The condition(s) this trial relates to.

Acid-Base Imbalance aortic valve stenosis coronary artery disorder disorder of acid-base balance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acid-base imbalance Cardiopulmonary bypass Crystalloid solutions Electrolyte changes Osmolality disturbance

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Skane University hospital

    RECRUITING

    Lund, 22185, Sweden

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