Region Skane

This study tests whether a structured care bundle—including rapid blood pressure control, reversal of blood thinners, and management of fever and blood sugar—can improve outcomes for people with a brain bleed. About 3500 adults in Sweden and Australia will receive either the care…

This study is testing whether a Mediterranean-like diet called Nordiet can improve gut health and reduce inflammation in 160 teens and adults with Crohn's disease or ulcerative colitis. Participants will follow the diet for four weeks while researchers check changes in gut bacter…

This study tests whether adding a small implant in the sinus tarsi (a space in the foot) to standard flatfoot surgery helps correct the deformity better than surgery alone. Researchers will enroll 130 adults with flexible flatfoot who haven't improved with non-surgical treatments…

This study tests whether giving fewer non-resuscitation fluids to adults with septic shock can reduce harm and improve survival. About 1,850 participants will be randomly assigned to a restrictive fluid strategy or usual care. The main goal is to see if the restrictive approach l…

This study is for women with early-stage breast cancer that has spread to 1-2 lymph nodes. It tests whether skipping radiation to the lymph nodes can reduce side effects and improve quality of life without increasing the risk of cancer coming back. About 1,350 participants will b…

This study looks at the best way to sequence EGFR-inhibitor drugs for people with advanced EGFR-mutated lung cancer that cannot be cured. About 200 participants will receive different orders of these targeted therapies, and researchers will track tumor response, side effects, and…

This study explores whether trained volunteers with the overdose-reversal drug naloxone can reach people having an opioid overdose faster than emergency services. About 1,000 volunteers will be alerted via a smartphone app when a suspected overdose is reported. The goal is to see…

This study tests whether psilocybin, a psychedelic substance, given with psychological support is safe and helps reduce symptoms of anorexia nervosa in young adults aged 16 to 35. Participants receive two doses of psilocybin (25 mg) four weeks apart, plus therapy before, during, …

This study looks at whether removing certain food additives (like carrageenan and polysorbates) from the diet can improve symptoms and gut health in people with moderately active ulcerative colitis. About 70 participants will be randomly assigned to either a normal healthy diet o…

This study tests whether keeping the umbilical cord attached while resuscitating full-term newborns during emergency C-sections leads to better health outcomes. Researchers will compare this approach to standard care in 2,200 babies. The main goal is to see if fewer babies need i…

This study tests whether penicillin works better than the usual antibiotic cloxacillin for people with a Staph blood infection that is sensitive to penicillin. About 420 adults will be randomly assigned to one of the two treatments. The main goal is to see who survives 90 days wi…

This study tests if transplanting healthy bacteria into the nose can reduce symptoms of chronic sinusitis, a condition where the sinuses are inflamed for more than 12 weeks. About 50 adults with chronic sinusitis will receive either a bacteria transplant or a placebo, and then sw…

This study is testing whether two light-based imaging methods (diffuse reflectance spectroscopy and photoacoustic imaging) can accurately tell the difference between healthy breast tissue, benign tumors, and malignant tumors. About 90 adults with a breast tumor larger than 1 cm w…

This study is testing whether non-experts can use AI-supported ultrasound to screen for breast cancer in communities with limited resources. About 4,800 women (asymptomatic from age 30, or symptomatic from age 18) will receive a clinical breast exam and AI-guided ultrasound. The …

This study is testing whether having a dental checkup before heart valve surgery can prevent serious complications like infection of the heart lining, repeat surgery, or death. About 1,300 adults scheduled for valve surgery will be randomly assigned to either get a dental screeni…

This study tests a method called Safety Planning Intervention (SPI) to help prevent suicide. SPI is a single 45-minute session where a healthcare provider helps a person at risk create a personal crisis plan and connect to support. The study will involve 8,000 adults in Swedish p…

This study tests whether a special type of artificial light that changes throughout the day can improve sleep, body clock function, and overall well-being in frail older adults. Researchers will enroll 300 people over age 65 who are staying in hospital rooms equipped with this dy…

This study tests whether adding a lightweight SAM splint to usual pain relief helps adults with suspected wrist fractures feel less pain while waiting for X-rays in the emergency department. About 120 participants with moderate to severe pain will be randomly assigned to get a sp…

This study tests a new, organized rehabilitation program for people with esophageal or stomach cancer. The goal is to help them feel better, have fewer symptoms, and enjoy a higher quality of life. About 100 adults in southern Sweden who are scheduled for surgery will take part. …

This study tests whether keeping a special chest tube in place for up to 3 days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get the tube p…

This study tests whether L-menthol, a minty compound, can reduce breathlessness and help people with interstitial lung disease (ILD) exercise longer. About 20 adults with ILD will try L-menthol and a placebo in random order, comparing their breathing and exercise ability. The goa…

This study compares two approaches to treating anxiety in children and teens aged 8-17. In stepped care, everyone starts with online therapy and gets in-person sessions if needed. In stratified care, participants are assigned to online or in-person therapy based on their needs. T…

This study compares two methods of pain control during knee replacement surgery. One uses numbing medicine injected into the knee area only. The other adds nerve blocks to that injection. The goal is to see which approach provides better pain relief and reduces the need for stron…

This study tests whether a special vacuum bandage (negative pressure wound therapy) can prevent infections better than standard dressings after skin grafts on the lower leg. About 242 adults who have a skin tumor removed and need a skin graft will take part. The bandage is applie…

This study tests a new treatment program for people with severe, hard-to-treat self-harm. The goal is to see if it improves daily life, reduces self-harm, and lowers hospital stays. About 30 adults who have not been helped by other treatments will take part.

This study tests a family-centered program for children and teens who have conflicts at home because of too much gaming or screen use. About 170 families in Swedish social services will take part. The program focuses on improving parent-child warmth and reducing arguments around …

This study looks at whether having access to a specialized palliative care clinic helps cancer patients feel more secure and reduces unnecessary hospital visits. Researchers will compare patients who use the clinic with those who do not, and also ask family members about their ex…

This study looks at whether a new, simpler guideline can safely reduce the number of tests, hospital stays, and antibiotics given to infants under 2 months old with fever. Researchers will compare hospitals using the new guideline to those using standard care. The goal is to see …

This study looks at how different fluids used to fill the heart-lung machine before heart surgery affect the body's balance. 80 adults having bypass or valve surgery will be split into four groups, each receiving a different priming solution. Researchers will track changes in aci…

This study tests whether a 3D image overlay (fusion imaging) helps doctors reach and remove blood clots in the brain faster during a standard stroke procedure. About 300 adults having emergency clot removal will be randomly assigned to get the extra imaging or not. The goal is to…

This study follows 415 people with difficult-to-treat depression for 5 years after they joined an earlier genetics study. Researchers will review medical records and registry data to see how patients' depression changes over time, including suicide attempts and treatment response…

This study looks back at medical records of 3,000 adults who had emergency surgery at a Swedish hospital between 2009 and 2019. Researchers want to find out what factors increase the risk of death, complications, or needing another surgery. The goal is to improve care for future …

This study looks at new guidelines for diagnosing and managing breath-holding spells in children under 5 in southern Sweden. Researchers want to see if the guidelines safely reduce the need for extra tests like ECGs and blood work. They will also check if iron supplements help le…

This study follows 500 adults seeking gender-affirming care to understand how treatment affects their quality of life, mental health, and ability to work. Researchers will track participants for up to 5 years using surveys and national health records. The goal is to learn which f…

This study looks at how Huntington disease affects social skills, like understanding others' feelings and intentions. Researchers will test a new tool called DMASC-MC in 40 adults with early Huntington disease and compare results to healthy volunteers. The goal is to find better …

This study looks at people with Irritable Bowel Syndrome (IBS) who have a reduced ability to break down starch and sugar due to low enzyme levels. Researchers want to see if these individuals have a smaller rise in blood sugar after a meal and more bowel symptoms compared to thos…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…