New study aims to ease pain after knee replacement
NCT ID NCT07350252
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two methods of pain control during knee replacement surgery. One uses numbing medicine injected into the knee area only. The other adds nerve blocks to that injection. The goal is to see which approach provides better pain relief and reduces the need for strong painkillers. About 200 adults having knee replacement will take part.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: -Undergoing primary unilateral total knee arthroplasty Exclusion Criteria: * Pregnancy * Coagulopathy or other bleeding disorder that precludes regional anesthesia * Allergy to local anesthetics * Inability to understand spoken and written Swedish * Unwillingness to participate in the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Department of Anaesthesiology, Trelleborg Hospital
RECRUITINGTrelleborg, Sweden
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- One shot in the knee: can hyaluronic acid quiet osteoarthritis pain?
- Can your own cells ease osteoarthritis pain?
- Can your own bone marrow beat steroids for knee pain?
- Can a smaller cut in robotic knee surgery mean less pain and faster healing?
- One shot, one year: could a single injection ease knee arthritis pain?
- Ultrasound may predict which patients get poor pain relief from a common knee block