Region Skane

This study tests whether adding a small implant in the sinus tarsi (a space in the foot) to standard flatfoot surgery helps correct the deformity better and improves long-term function. About 130 adults with flexible flatfoot will be randomly assigned to get the standard surgery …

This study looks at the best way to sequence EGFR-inhibitor drugs for people with advanced EGFR-mutated lung cancer that cannot be cured. About 200 participants will receive different orders of these targeted therapies, and researchers will track tumor response, side effects, and…

This study explores whether trained volunteers with the overdose-reversal drug naloxone can reach people having an opioid overdose faster than emergency services. About 1,000 volunteers will be alerted via a smartphone app when a suspected overdose is reported. The goal is to see…

This study tests whether giving fewer non-resuscitation fluids to adults with septic shock (a severe infection causing low blood pressure) is safer and more effective than usual care. About 1,850 participants will be randomly assigned to either a restrictive fluid strategy or sta…

This study tests whether psilocybin, a psychedelic substance, given with psychological support is safe and helps reduce symptoms of anorexia nervosa in young adults aged 16 to 35. Participants receive two doses of psilocybin (25 mg) four weeks apart, plus therapy before, during, …

This study tests whether a structured package of treatments—including early blood pressure control, fever management, and blood sugar regulation—can improve recovery for people with a brain hemorrhage. About 3,500 adults in Sweden and Australia will take part. The goal is to see …

This study looks at whether a Mediterranean-style diet (adapted for Nordic countries) can improve gut health and reduce inflammation in people with moderate Crohn's disease or ulcerative colitis. Researchers will also explore how exercise, sexual health, and quality of life relat…

This study looks at whether removing certain food additives (like carrageenan and polysorbates) from the diet can improve symptoms and gut health in people with moderately active ulcerative colitis. About 70 participants will be randomly assigned to either a normal healthy diet o…

This study tests whether keeping the umbilical cord attached while resuscitating full-term newborns during emergency C-sections leads to better health outcomes. Researchers will compare this approach to standard care in 2,200 babies. The main goal is to see if fewer babies need i…

This study tests whether women with early-stage, hormone-positive breast cancer and cancer in 1-2 lymph nodes can safely avoid radiation to the armpit area. By skipping this extra radiation, the goal is to reduce side effects and improve quality of life without increasing the cha…

This study tests whether penicillin works better than the usual antibiotic cloxacillin for people with a Staph blood infection that is sensitive to penicillin. About 420 adults will be randomly assigned to one of the two treatments. The main goal is to see who survives 90 days wi…

This study tests if transplanting healthy bacteria into the nose can reduce symptoms of chronic sinusitis, a condition where the sinuses are inflamed for more than 12 weeks. About 50 adults with chronic sinusitis will receive either a bacteria transplant or a placebo, and then sw…

This study is testing whether two light-based imaging methods (diffuse reflectance spectroscopy and photoacoustic imaging) can accurately tell the difference between healthy breast tissue, benign tumors, and malignant tumors. About 90 adults with a breast tumor larger than 1 cm w…

This study is testing whether non-experts can use AI-supported ultrasound to screen for breast cancer in communities with limited resources. About 4,800 women (asymptomatic from age 30, or symptomatic from age 18) will receive a clinical breast exam and AI-guided ultrasound. The …

This study is testing whether a dental checkup before heart valve surgery can help prevent serious infections, the need for another surgery, or death. About 1300 adults who are scheduled for heart valve surgery will be randomly assigned to either have a dental screening or not. T…

This study tests a method called Safety Planning Intervention (SPI) to help prevent suicide. SPI is a single 45-minute session where a healthcare provider helps a person at risk create a personal crisis plan and connect to support. The study will involve 8,000 adults in Swedish p…

This study tests a new, organized rehabilitation program for people with esophageal or stomach cancer. The goal is to help them feel better, have fewer symptoms, and enjoy a higher quality of life. About 100 adults in southern Sweden who are scheduled for surgery will take part. …

This study tests whether keeping a special chest tube in place for up to 3 days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get the tube p…

This study tests whether L-menthol, a minty compound, can reduce breathlessness and help people with interstitial lung disease (ILD) exercise longer. About 20 adults with ILD will try L-menthol and a placebo in random order, comparing their breathing and exercise ability. The goa…

This study compares two approaches to treating anxiety in children and teens aged 8-17. In stepped care, everyone starts with online therapy and gets in-person sessions if needed. In stratified care, participants are assigned to online or in-person therapy based on their needs. T…

This study compares two methods of pain control during knee replacement surgery. One uses numbing medicine injected into the knee area only. The other adds nerve blocks to that injection. The goal is to see which approach provides better pain relief and reduces the need for stron…

This study tests whether a special vacuum bandage (negative pressure wound therapy) can prevent infections better than standard dressings after skin grafts on the lower leg. About 242 adults who have a skin tumor removed and need a skin graft will take part. The bandage is applie…

This study tests whether a special type of lighting that changes throughout the day can improve sleep, daily rhythms, and well-being in frail older adults (65+) staying in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The goal is to help p…

This study tests a new treatment program for people with severe, hard-to-treat self-harm. The goal is to see if it improves daily life, reduces self-harm, and lowers hospital stays. About 30 adults who have not been helped by other treatments will take part.

This study tests a family-centered program for children and teens who have conflicts at home because of too much gaming or screen use. About 170 families in Swedish social services will take part. The program focuses on improving parent-child warmth and reducing arguments around …

This study tests whether adding a SAM aluminum splint to standard pain relief reduces pain for adults with suspected wrist fractures in the emergency department. About 120 participants with moderate to severe pain will be randomly assigned to get a splint or not. The main goal is…

This study looks at whether having access to a specialized palliative care clinic helps cancer patients feel more secure and reduces unnecessary hospital visits. Researchers will compare patients who use the clinic with those who do not, and also ask family members about their ex…

This study looks at whether fusing 3D scans with live X-ray images helps doctors guide a catheter to the blocked artery more quickly during stroke clot removal. About 300 adults having emergency clot removal will be included. The goal is to see if this technique improves success …

This study looks at whether a new, simpler guideline can safely identify which febrile infants under 60 days old truly need tests and antibiotics. About 2,500 babies across 11 Swedish hospitals will be observed, with some hospitals using the new guideline and others sticking to c…

This study looks at how Huntington disease affects social skills, like understanding others' feelings and intentions. Researchers will test a new tool called DMASC-MC in 40 adults with early Huntington disease and compare results to healthy volunteers. The goal is to find better …

This study follows 500 adults referred for gender-affirming care in Sweden to understand how treatment impacts their mental health, quality of life, and ability to work. Researchers will track participants for up to 5 years using surveys and national health records. The goal is t…

This study looks at new guidelines for diagnosing and managing breath-holding spells in children under 5 in southern Sweden. Researchers want to see if the guidelines safely reduce the need for extra tests like ECGs and blood work, and if iron supplements help lessen the spells. …

This study follows 415 people with difficult-to-treat depression for 5 years after they joined an earlier genetics study. Researchers will review medical records and registry data to see how patients are doing, track suicide attempts, and look for links between genes and treatmen…

This study looks at people with Irritable Bowel Syndrome (IBS) who have a reduced ability to break down starch and sugar due to low enzyme levels. Researchers want to see if these individuals have a smaller rise in blood sugar after a meal and more bowel symptoms compared to thos…

This study looks at how the fluid used to fill the heart-lung machine before heart surgery affects the body's acid-base balance, salt levels, and water balance. About 80 adults having either bypass or aortic valve replacement will be randomly assigned to one of four different pri…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…