ACUTE ISCHEMIC STROKE

This study looks at whether giving a clot-busting drug (tenecteplase) before transferring a patient to a specialized stroke center can improve recovery for people with a severe type of stroke caused by a blockage in the basilar artery. The trial involves 316 adults who had a stro…

This study looks at whether telemedicine can help smaller hospitals in China treat people having a stroke more effectively. About 2,400 patients will take part. Some hospitals will get remote guidance from stroke experts, while others will not. The goal is to see if telemedicine …

This study tests whether using a blood test to choose the right antiplatelet drug can prevent another stroke in people who recently had a mild stroke or a mini-stroke. About 5,138 participants will be assigned to standard care or a personalized drug switch if they show resistance…

This study tests a new drug, MT200605, in 360 people who had a stroke within the last 24 hours. The drug aims to protect brain cells and reduce damage. Participants receive either a low, medium, or high dose of the drug or a placebo, along with standard care. The main goal is to …

This study tests whether exosomes (tiny particles) from stem cells can help people who recently had a stroke. About 29 adults aged 18-70 will receive either the exosomes or a placebo through an IV. The main goal is to check safety, but researchers will also see if it improves rec…

This study tests a new medicine called SHPL-49 given through a vein to people who have had a stroke caused by a blood clot. The goal is to see if it helps them recover better and have less disability. About 1,096 adults aged 18 to 80 who are already getting standard clot-busting …

This study tests whether starting comprehensive heart rhythm control early after a stroke caused by atrial fibrillation can prevent future strokes, heart failure, or heart attacks. About 1,700 adults who had a stroke in the last month and were recently diagnosed with atrial fibri…

This study tests whether adding a drug called tirofiban after standard clot-busting treatment helps people recover better from a severe stroke. About 976 adults who did not improve enough after initial treatment will receive either tirofiban or a placebo for 24 hours. The main go…

This study is testing a medical device designed to quickly restore blood flow in people having a severe stroke caused by a blocked artery in the brain. About 500 adults who are treated within 8 hours of their stroke symptoms starting will take part. The goal is to see how well th…

This study tests a clot-busting drug called tenecteplase in Chinese stroke patients who arrive at the hospital more than 4.5 hours after symptoms start. About 890 participants will receive either the drug or standard care to see if it helps them recover without disability. The go…

This study tests a new device called Ceretrieve that removes blood clots from brain arteries in people having a severe stroke. About 132 participants will be treated within 24 hours of symptoms starting. The goal is to see if the device safely restores blood flow, comparing resul…

This study looks at whether two different versions of Angong Niuhuang Pills can help people recover from an acute ischemic stroke. Researchers will enroll 100 adults aged 18-80 and follow them for 84 days to check brain function, gut health, and immune response. The goal is to se…

This study tests a new medicine called QD202 in people who have had a stroke caused by a blood clot and are receiving standard clot-busting treatment. The goal is to see if QD202 is safe and helps improve recovery. About 120 adults will receive either QD202 or a placebo as an IV …

This study tests whether placing a stent in a narrowed brain artery after removing a clot can improve recovery and reduce bleeding risk in stroke patients. About 342 adults aged 18-80 with severe stroke and significant artery narrowing will be enrolled. The approach combines stan…

This study tests whether giving a powerful cholesterol-lowering drug (evolocumab) along with standard statins within 48 hours of a stroke can prevent early brain function decline. About 429 adults with moderate-to-severe artery narrowing in the brain will be randomly assigned to …

This study looks at whether giving a clot-busting drug called Tenecteplase to stroke patients at a local hospital, before they are transferred to a specialized center for a procedure to remove the clot, can improve their recovery. The trial involves 572 adults with a specific typ…

This study tests whether adding the drug tirofiban to a standard clot-removal procedure helps people recover better after a severe stroke caused by hardened arteries. About 716 adults who have had a stroke within the past 24 hours will receive either tirofiban or a placebo after …

This study tests whether giving the steroid methylprednisolone right after a stroke clot removal procedure can help patients recover better. About 1,060 adults who had a large-vessel stroke will receive either the steroid or a placebo through an artery and then intravenously for …

This study looks at whether placing a small tube (stent) in the neck artery, along with the usual procedure to remove a blood clot from the brain, helps people recover better after a severe stroke. About 400 adults aged 18 to 79 with a specific type of stroke will be randomly ass…

This study tests whether giving a clot-dissolving drug directly into the brain's arteries can improve recovery for people with acute stroke caused by medium-sized vessel blockages. About 382 adults who have had a stroke within the last 24 hours will be randomly assigned to receiv…

This study tests a new drug called sovateltide for people who have had a stroke caused by a blood clot in the brain. The goal is to see if it helps patients recover better and have less disability. About 514 adults aged 18 to 80 will receive the drug or a placebo alongside standa…

This study tests a drug called JX10 in people who have had a stroke and arrive at the hospital 4.5 to 24 hours later. The goal is to see if JX10 can help them recover better and with fewer complications than a placebo. About 740 adults aged 18 to 90 with certain types of stroke w…

This study tests a new drug called LT3001 for people who have had a stroke caused by a blood clot. The goal is to see if it helps patients recover better and with fewer side effects. About 300 adults aged 18 to 80 will receive either the drug or a placebo within 24 hours of their…

This study tests whether giving aspirin within 3 hours of clot-busting medication for stroke can improve recovery and prevent further damage. About 1,184 adults who had a stroke and still have symptoms after initial treatment will receive either aspirin or a placebo. The goal is …

This study tests a new device called the CONDA stent retriever in 50 people who have had a stroke caused by a large blood clot in the brain. The goal is to see if the device can safely reach and remove the clot to restore blood flow. Participants must be treated within 24 hours o…

This study tests a new drug called TBO-309 in 80 people who have had a stroke caused by a blocked artery. The drug is given alongside standard treatments to help keep the artery open and prevent it from blocking again. The main goal is to check if the drug is safe and does not ca…

This study tests a new device called the RapidPulse Aspiration System to remove blood clots from the brains of people having a severe stroke. The goal is to see if it is safe and effective at restoring blood flow quickly. Participants must be treated within 8 hours of stroke symp…

This study tests whether adding an anti-inflammatory drug to a standard clot-removal procedure helps people recover better after a major stroke. About 692 adults with a large-vessel blockage in the front part of the brain will receive either the drug or a placebo during their eme…

This study tests whether giving a clot-dissolving medicine directly into the brain artery, on top of the usual mechanical clot removal, helps people recover better from a stroke caused by a medium-sized blockage. About 530 adults with acute ischemic stroke will be randomly assign…

This study tests a new drug called BB-031 in people who have had a stroke caused by a blood clot. The goal is to see if the drug is safe and tolerable when given within 24 hours of stroke symptoms starting. About 228 participants will receive either the drug or a placebo and be m…

This study looks at how well a device called the NeVa stent-retriever removes blood clots from the brain in people having a severe stroke. About 600 adults who are already being treated with this device will be followed to see if it can restore blood flow in a single attempt. The…

This study looks at whether slightly raising blood pressure after a stroke clot removal procedure helps patients recover better than the usual approach. About 176 adults who had a stroke and whose blood pressure stays low after the procedure will be randomly assigned to either a …

This study tests whether stroke patients who take FXa inhibitor blood thinners can safely receive a standard clot-busting drug (IVT) without raising their risk of brain bleeding. Current guidelines deny IVT to these patients due to bleeding concerns, but new evidence suggests it …

This study tests whether a procedure to remove blood clots from the brain can help people who have had a major stroke 24 to 72 hours earlier. About 382 adults with severe stroke symptoms will be randomly assigned to get the procedure plus standard care or standard care alone. The…

This study tests whether a drug called Aleeto can help people recover better after a moderate to severe stroke caused by a blood clot. About 192 adults aged 30 to 80 who have had a stroke within the last 72 hours will receive either Aleeto or a placebo. The main goal is to see if…

This study is testing a new catheter (a thin tube) designed to remove blood clots from small and medium-sized brain arteries in people having an acute ischemic stroke. About 57 adults who have had a stroke within the last 24 hours and meet specific brain scan criteria will receiv…

This study tests a simple, noninvasive treatment called remote ischemic conditioning (RIC) for people who had a stroke caused by a large clot and underwent a procedure to remove it. RIC involves briefly inflating a blood pressure cuff on an arm or leg in cycles, which may protect…

This study looks at whether giving two blood-thinning drugs (clopidogrel and aspirin) together for 21 days after a stroke is safe and works better than aspirin alone to prevent another stroke. About 200 adults who recently had a stroke and are at low bleeding risk will take eithe…

This study looks at whether carefully adjusting blood pressure during clot-busting treatment for stroke can lower the risk of dangerous bleeding in the brain. About 340 adults aged 18 to 80 with acute ischemic stroke and high blood pressure will take part. Researchers will compar…

This study tests whether a procedure to remove blood clots from a medium-sized brain artery can help people who have had a moderate-to-severe stroke. About 200 adults aged 18-84 who are not helped by standard clot-busting drugs will be randomly assigned to receive the procedure o…

This study tests an investigational drug called QHRD106 for people who have had an acute ischemic stroke. The goal is to see if it can improve recovery and reduce disability when given within 24 hours of stroke onset. About 320 adults aged 18 to 80 who have not received standard …

This study tests whether giving the blood-thinning drug tirofiban soon after standard clot-busting treatment helps people recover better from a stroke. About 1,084 adults who had a moderate stroke will receive either tirofiban or a placebo within 6 hours of their first treatment.…

This study is for people who have had a stroke caused by a blockage in the main artery in the neck. It compares standard medical treatment alone to standard treatment plus a procedure to open the blocked artery. The goal is to see if the procedure helps more people recover with l…

This study tests whether removing a blood clot from the brain up to 72 hours after a stroke helps people recover better than medication alone. About 408 adults with severe stroke will be randomly assigned to get either the clot removal procedure plus standard care, or standard ca…

This study tests whether giving albumin, a protein found in blood, along with standard clot-removal treatment helps people recover better after a severe stroke. About 1,200 adults aged 18-80 with a specific type of stroke will be enrolled. The goal is to see if more people can li…

This study compares a procedure to remove blood clots from the brain (endovascular therapy) with standard medical treatment for people who have had a mild stroke caused by a blockage in a large artery. About 264 adults with mild symptoms (NIHSS score 2-5) will be enrolled within …

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This study tests an experimental drug called HRS-7450 in 208 people who have had an acute ischemic stroke. Participants must start treatment between 4.5 and 24 hours after symptoms begin. The main goal is to see if the drug helps patients achieve a good recovery (little or no dis…

This study tests a single injection of stem cells (B2065) given within 36 hours of a stroke. About 54 adults aged 18–75 with moderate-to-severe stroke will receive either the stem cells or a placebo. Researchers will monitor safety and check if the treatment helps improve recover…

This study tests whether a single infusion of stem cells from donated umbilical cord blood (Neuroncell-EX) can help people recover better after a moderate to severe stroke. About 80 adults who had a stroke within the past 4 weeks and cannot receive standard clot-busting drugs wil…

This study tests whether a single dose of TAK-755 is safe and helps people recover after an acute ischemic stroke (a clot blocking blood flow to the brain). About 222 adults aged 18–80 will receive either TAK-755 or a placebo, plus standard stroke care. Researchers will monitor f…

This study tests a new treatment for people who have had a stroke caused by a blood clot. A weak electrical current is applied to the scalp to increase blood flow to the brain and protect tissue at risk of damage. The goal is to find the safest and most effective dose. About 120 …

This study tests whether giving a second drug, tirofiban, soon after the standard clot-busting drug tenecteplase can improve outcomes for people with acute ischemic stroke. About 348 adults who had a stroke and received tenecteplase will be enrolled. The goal is to see if the com…

This study tests whether a clot-busting drug called tenecteplase can help people having a stroke who have recently taken blood thinners (DOACs). About 912 participants will receive either the drug or a placebo to see if it improves their recovery after 90 days. The goal is to fin…

This study tests an experimental drug called KPCXM18 in people who have had a stroke caused by a blood clot. The goal is to see if the drug helps patients recover better than a placebo. About 300 adults aged 18 to 80 will receive either the drug or a placebo within 12 hours of th…

This study tests a drug called rhTNK-tPA (Mingfule) to see if it can help people who have had a major stroke and can be treated between 4.5 and 24 hours after symptoms start. About 890 participants will receive either the drug or a placebo. The goal is to see if the drug improves…

This study looks at whether adding a drug called evolocumab (a PCSK9 inhibitor) to standard statin treatment helps people recover better after a stroke caused by hardening of the large arteries. About 1000 adults aged 18-80 who recently had a stroke will be enrolled. The goal is …

This study looks at how safe and effective the EmboTrap II device is at removing blood clots in people having a severe stroke. About 100 participants will be watched to see if the device can restore blood flow to the brain without causing harm. The goal is to improve recovery by …

This study looks at whether measuring how well the brain controls its own blood flow during a stroke procedure can help doctors know early if the treatment will work. About 129 adults having a stroke due to a blocked large artery will be monitored during treatment and followed fo…

This study tests a traditional Chinese herbal formula, Qingre Huatan, to see if it can prevent early neurological decline in people who have just had a stroke. About 72 adults who had a stroke within the last 48 hours and are at high risk of getting worse will receive either the …

This study looks at two different ways to keep patients comfortable and calm during emergency surgery to remove a blood clot from the brain after a stroke. The goal is to find out which method helps people recover better and have fewer problems. About 810 adults with a severe str…

This study aims to find the safest and most effective dose of urokinase, a clot-busting drug, for people having an acute ischemic stroke. Researchers will enroll 24 adults aged 18-80 who can receive treatment within 6 hours of symptoms starting. The goal is to develop a weight-ba…

This study tests whether tilting the head down 15° during a stroke, just before a procedure to remove a blood clot, can improve blood flow to the brain and lead to better outcomes. About 118 adults having a stroke due to a blocked artery will be randomly assigned to either head-d…

This study tests whether the clot-busting drug tenecteplase can help people who had a stroke more than 4.5 hours ago or woke up with stroke symptoms. About 1,325 adults with brain scans showing salvageable tissue will receive either tenecteplase or standard care. The goal is to s…

This study is not testing a new treatment. Instead, it gathers information on how well BALT medical devices work and how safe they are in everyday use for conditions like brain aneurysms, stroke, and blocked arteries. Up to 10,000 people will be included, and researchers will tra…

This study aims to build an AI system that predicts which type of rehabilitation will work best for each stroke survivor. Researchers will collect data from 400 participants, including brain scans, muscle activity, and genetic information, before they receive standard rehab or tr…

This study is a large registry that will collect information from 1,000 people treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in real-life settings, such as how completely aneurysms are closed or how well blood …

This study looks at how a stroke can disrupt the body's automatic functions like heart rate and blood pressure. Researchers will compare 100 people who had a stroke or a mini-stroke using brain scans, blood tests, and heart function tests. The goal is to better understand why the…

This study collects blood, clots, and tissue from 1000 people having stroke-related procedures. Researchers will analyze these samples to find biological markers and understand how stroke affects the body. The goal is to improve future treatments by learning directly from human s…

This study looks at why some stroke patients don't recover well even after treatment to reopen large brain arteries. Researchers think tiny blood clots in smaller vessels may be the cause. They will use special MRI scans and tissue samples from 15 patients who need surgery to rel…

This study compares two ways to reach the blocked artery in a severe stroke: through the wrist (radial artery) or the groin (femoral artery). About 386 adults with a specific type of stroke (basilar artery occlusion) will be randomly assigned to one method. The goal is to see whi…

This study looks at whether a gentle electrical stimulation of a nerve in the ear can help people who have had a major stroke. Researchers will measure markers of brain injury and inflammation in the blood. 65 adults with a recent stroke will either get standard care or standard …

This study aims to find new biomarkers in blood and saliva that can quickly and accurately tell if someone is having a stroke. Researchers will study 650 adults with suspected stroke to improve early detection and diagnosis. The goal is to develop better tools to differentiate st…

This worldwide study looks at a rare but serious complication—a blood vessel tear—that can happen during a stroke treatment called thrombectomy. Researchers will study 1000 patients to understand what causes the tear, how to classify it, and how to stop bleeding quickly. The goal…

This study looks at 100 people who recently had a stroke and need surgery to open a blocked neck artery. Half will get numbing medicine only in the neck (regional anesthesia), and the other half will be fully asleep (general anesthesia). The goal is to see which method leads to f…