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Could a simple head tilt improve stroke recovery?

NCT ID NCT06297863

Disease control Sponsor: University of Milano Bicocca Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether tilting a stroke patient's head down 15 degrees for 30-90 minutes before a clot removal procedure can improve blood flow to the brain. About 118 adults with a specific type of stroke will be randomly assigned to either the head-down tilt or standard positioning. The goal is to see if this simple position change helps keep brain tissue alive and boosts the benefits of the clot removal procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
head down tilt positioning (procedure)
What this could lead to
If it works, this simple head-down tilt could improve blood flow to the brain during a stroke, potentially reducing disability and improving recovery after clot removal.
What could go wrong
This is an early phase 2 trial with only 118 participants, so results may not apply to all stroke patients. The tilt might cause discomfort, vomiting, or delays in treatment, and it is not yet proven to improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 118 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Acute ischemic stroke due to left or right MCA occlusion of the M1 segment (excluding occlusion of the internal carotid artery terminus + M1) * Decision to treat with mechanical thrombectomy (with or without intravenous thrombolysis) * Informed consent obtained from patient or patient's next of kin, or emergency consent procedure Exclusion Criteria: * Impaired consciousness, defined as NIHSS score of 2 or 3 of the item 1a (level of consciousness): not alert, requires repeated stimulation or unresponsive. * Vomiting upon stroke onset. * History of glaucoma. * History or imaging findings of intracranial hypertension of any aetiology * Major breath disorders, defined as follows: * oxygen saturation ≤92% in room air at admission * severe chronic obstructive pulmonary disease (COPD) treated with long-term oxygen therapy. * severe heart failure with NYHA class 3 or 4 (breathlessness during ordinary physical activity or at rest). * Severe obesity, defined as body mass index (BMI) \> 35. * Patients participating in another interventional trial that would interfere with this study. * Female patients who are pregnant

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Conditions

The condition(s) this trial relates to.

ischemic stroke middle cerebral artery infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute ischemic stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Azienda Ospedaliera Policlinico Universitario "G. Martino"

    NOT_YET_RECRUITING

    Messina, 98124, Italy

  • Azienda Ospedaliero Universitaria Careggi

    NOT_YET_RECRUITING

    Florence, 50134, Italy

  • Azienda Ospedaliero Universitaria Policlinico Umberto I

    NOT_YET_RECRUITING

    Roma, 00161, Italy

  • Fondazione IRCCS San Gerardo dei Tintori Monza

    RECRUITING

    Monza, 20900, Italy

  • Ospedale Civile SS. Nicola e Filippo Avezzano Pronto Soccorso

    NOT_YET_RECRUITING

    Avezzano, 67051, Italy

  • Ospedale Santa Maria della Misericordia

    NOT_YET_RECRUITING

    Udine, 33100, Italy

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