Can pressurized oxygen boost stroke recovery?
NCT ID NCT07049692
First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) helps people recover better after a stroke. About 424 adults aged 35-75 who had a stroke and received endovascular treatment will be randomly assigned to get either hyperbaric oxygen sessions or standard care. The main goal is to see if more patients achieve functional independence 90 days later.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hyperbaric oxygen therapy
- What this could lead to
- If it works, this could offer a new way to help stroke patients recover better after standard treatment.
- What could go wrong
- This is an early-stage trial with no phase, so results are uncertain. The therapy is time-consuming and may not improve outcomes for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 424 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2026
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 35-75 years * The symptoms and signs are consistent with acute anterior circulation ischemic stroke. The immediate postoperative angiographic recanalization grade was ≥ 2b. * Neurological deficit score at the time of enrollment: 5 ≤ NIHSS ≤ 15 points * Consciousness status (NIHSS 1a-1b items): 0-1 point * Pre-stroke functional status (mRS score): 0-1 * Time from surgery to randomization grouping: ≤ 72 hours * Patient or legal representative who signed the informed consent form * Preoperative CT angiography or magnetic resonance angiography confirmed large vessel occlusion (internal carotid artery or middle cerebral artery M1 segment) that was consistent with the symptoms and signs; And the area supplied by the middle cerebral artery in the brain is less than 1/3. * A lberta S troke P rogram E arly C T S core ≥ 6 Exclusion Criteria: * Subjects with HBO contraindications or intolerance * Postprocedural imaging identified either procedure-related subarachnoid hemorrhage or hemorrhagic transformation * Based on the medical history, it is suspected that the cerebral embolism is caused by sepsis or infective endocarditis * Expected lifespan \< 90 days * Severe heart, liver and kidneys failure * Pregnancy * Hereditary or acquired bleeding tendency, deficiency of coagulation factors, recent use of oral anticoagulants with an international normalized ratio (INR) \> 3 or activated partial thromboplastin time (APTT) exceeding the normal value by more than 3 times * Baseline platelet count \< 50×10 9/L * Baseline blood glucose is less than 2.78 mmol/L or greater than 22.2 mmol/L. * Unstable vital signs (heart rate ≤ 50 beats/min or ≥ 120 beats/min, oxygen saturation ≤ 90%, respiration ≥ 30 breaths/min or ≤ 10 breaths/min); * Hypertension that cannot be controlled by medication: Systolic blood pressure ≥ 160 mmHg, or diastolic blood pressure ≥ 100 mmHg; * Suspected of having acute myocardial infarction; * Currently involving in the research of other projects related to drugs or medical devices. * CT or MRI scans revealed intracranial tumors (except for cerebellar meningiomas) and intracranial arteriovenous malformations. * Based on the medical history and CT or MRI findings, a diagnosis of internal carotid artery dissection or aortic dissection is suspected; * Based on the medical history and CT or MRI findings, cerebral vasculitis is suspected. * Based on the clinical evidence of multiple vascular regions being occluded (either in the bilateral anterior circulation or anterior/posterior circulation) or bilateral infarction or multi-region infarction as detected by CT angiography or magnetic resonance angiography; * CT or magnetic resonance imaging shows a significant midline shift effect (\> 0.5 cm); * CT angiography or magnetic resonance angiography confirmed the presence of cerebral vasculitis or cerebral vasculitis syndrome;
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Beijing Chaoyang Hospital, Capital Medical University
NOT_YET_RECRUITINGBeijing, China
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Emergency Intensive Care Unit
RECRUITINGBeijing, Beijing Municipality, China
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