Can a smarter blood pressure approach make stroke Clot-Busting safer?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 to 80 years (inclusive); 2. Patients with acute ischemic stroke; 3. Planned to receive intravenous thrombolysis within 4.5 hours of onset; 4. Elevated blood pressure: Before receiving intravenous thrombolysis treatment, blood pressure is elevated: systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg (defined as two consecutive measurements within 2 minutes); 5. Informed consent signed (or signed by a proxy). Exclusion Criteria: 1. Intracranial hemorrhage is indicated on CT or MRI (including parenchymal hemorrhage, intraventricular hemorrhage, subarachnoid hemorrhage, subdural or epidural hematoma). 2. History of intracranial hemorrhage; severe head trauma or stroke within the last 3 months. 3. Intracranial tumors, giant intracranial aneurysms. 4. Intracranial or spinal surgery within the last 3 months; major surgery within the last 2 weeks; arterial puncture at a site not easily compressed for hemostasis within the last 7 days. 5. Gastrointestinal or urinary system bleeding within the last 3 weeks. 6. Aortic dissection. 7. Acute bleeding tendency, including platelet count \< 100×10\^9/L or other bleeding tendencies. 8. Received low-molecular-weight heparin orally within 24 hours; taking warfarin with INR \> 1.7 or PT \> 15 seconds; used a new oral anticoagulant within 48 hours. 9. Blood glucose \< 2.8 mmol/L or \> 22.2 mmol/L. 10. Large area cerebral infarction indicated on head CT or MRI (infarction area \> 1/3 of the middle cerebral artery territory). 11. Active visceral hemorrhage, known bleeding diathesis or significant bleeding disorders within the past 6 months 12. Severe ischemic stroke (NIHSS score \> 25) 13. Epileptic seizures at the time of stroke onset 14. Pregnant or lactating women 15. Various terminal diseases with an expected survival of ≤ 3 months 16. Any other physical conditions where the doctor deems participation in this study may be detrimental to the patient 17. Currently participating in other drug or device clinical trials 18. mRS score \> 2 before onset of the disease.