ACUTE ISCHEMIC STROKE

This study tested two blood thinners—tirofiban and aspirin—in 240 people who had a stroke caused by blockages in both the neck and brain arteries. After emergency surgery to open the arteries, patients received one of the two drugs to prevent the neck artery from reclogging. The …

This study tested a new way to protect the brain after a stroke. After doctors removed a blood clot, they briefly stopped blood flow to the brain using a balloon, then let it flow again. This was done to help the brain adapt and reduce swelling. The study included 25 adults with …

This study looked at 345 people with a severe type of stroke caused by a blockage in the main artery at the back of the brain. It compared two treatments: giving a clot-busting drug followed by a mechanical procedure to remove the clot, versus doing the mechanical procedure alone…

This study tested a drug called sodium sivelestat in 20 people who had a stroke caused by a large blood clot. The drug was given along with the standard procedure to remove the clot. The goal was to see if the drug could reduce brain inflammation and improve recovery. The study w…

This study tested a new medicine called SHPL-49 given as a daily IV for 7 days to people who had a stroke. The goal was to see if it helps them recover better and is safe. 270 adults aged 18-80 with moderate to severe stroke took part. The main measure was how independent they we…

This study tested whether a clot-dissolving medicine called rhTNK-tPA could help people having a stroke when given between 4.5 and 24 hours after symptoms started. It included 570 adults with a stroke that was not caused by a large blocked artery. The goal was to see if more pati…

This early-stage study tested a new drug called PP-007 in 24 people having an acute ischemic stroke (a stroke caused by a blood clot). Participants received two doses of the drug along with standard treatments like clot-busting medicine or mechanical clot removal. The main goal w…

This study tested whether giving a blood thinner (heparin) during a wrist-based brain scan can prevent the wrist artery from closing up afterward. The trial involved 440 adults who had a recent stroke and needed a cerebral angiogram. Researchers checked for artery blockage 24 hou…

This study tested whether trimetazidine, a drug typically used for heart conditions, can help people recovering from an acute ischemic stroke. Sixty adult stroke patients received the drug to see if it lowers inflammation and improves disability scores. The goal was to reduce bra…

This study tested an experimental drug called elezanumab in 121 people who had a recent stroke. The goal was to see if the drug could improve brain function and reduce disability compared to a placebo. Participants received the drug or placebo by IV within 24 hours of their strok…

This study tested a single dose of the experimental drug LT3001 in 24 adults who had an acute ischemic stroke (a stroke caused by a blood clot). The main goal was to see if the drug is safe and does not cause dangerous bleeding in the brain. Participants received either LT3001 or…

This study looked at 204 people who had an acute ischemic stroke to see if starting a drug called butylphthalide very early (within 3 hours) helps recovery more than starting it later (3-6 hours). The goal is to find the best time to give this treatment to improve brain function …

This early-stage study tested a new drug called HRS-7450 in 64 adults who had an acute ischemic stroke (a stroke caused by a blood clot). The main goal was to see if the drug is safe and tolerable, especially regarding the risk of bleeding in the brain. Researchers also looked at…

This study tested a new drug, LT3001, in 89 adults who had an acute ischemic stroke (a stroke caused by a blood clot). The goal was to see if the drug is safe and helps recovery when given within 24 hours of symptoms. Participants received either the drug or a placebo, and resear…

This study tested a clot-busting drug called non-immunogenic staphylokinase in over 23,000 people who had an acute ischemic stroke. The goal was to see how safe and effective the drug is in everyday hospital settings. Patients received the drug within 4.5 hours of their first sym…

This early study tested a new device that cools the brain in 8 people who had a stroke caused by a blocked artery. After doctors removed the clot, the device cooled the brain for 30 minutes to try to prevent further damage. The main goal was to see if the cooling process was safe…

This study looked at whether giving the drug tirofiban after a mechanical clot removal procedure helps people recover better from a severe stroke. About 1380 adults with a large blood clot in the front part of the brain were treated within 24 hours of symptoms starting. The goal …

This study tested a new tool called the Millipede System to remove large blood clots from the brains of people having a severe stroke. Researchers wanted to see if the device could safely restore blood flow within three tries. The study included 246 adults aged 18 to 85 who had a…

This study tested a drug called conestat alfa (Ruconest) to see if it could prevent strokes and kidney damage in people getting a new heart valve without open-heart surgery (TAVI). About 141 patients with severe aortic stenosis took part. The drug aims to reduce brain lesions and…

This study tested whether kinesio taping (a special elastic tape placed on the skin) can improve arm and hand movement, reduce pain, and boost mood in people who recently had a stroke. 26 adults with arm weakness were randomly assigned to receive either real kinesio taping or a f…

This study tested whether giving N-Acetylcysteine (NAC) through an IV can help people who have had a stroke. NAC is an antioxidant and anti-inflammatory drug already used safely for other conditions. The trial enrolled 4 adults with acute ischemic stroke to see if it improves bra…

This study tested whether a mild electrical stimulation on the ear (called taVNS) could reduce inflammation in 40 adults who had a recent stroke from a blocked large artery. Participants received either standard care or standard care plus the ear stimulation. The main goal was to…

This study looked at 34 adults with acute ischemic stroke and very high blood pressure who needed treatment quickly. Researchers compared two drugs, nicardipine and labetalol, to see which one lowered blood pressure to a safe level faster before clot-busting therapy. The goal was…

This study tested whether an artificial intelligence (AI) tool helps doctors and radiographers read head CT scans more accurately and quickly. 33 readers reviewed 150 scans, some normal and some showing brain injuries like bleeding or stroke. The goal was to see if AI assistance …

This study looked at whether special brain scans and blood tests can predict serious problems that can happen after a stroke, like brain swelling or bleeding. Researchers studied 213 people who had a stroke and also used mice to understand the brain changes better. The goal was t…

This early-stage study tested the safety of a new drug called LT3001, which is being developed for acute ischemic stroke. Researchers gave the drug to 65 healthy adults to see how it interacts with common medications like aspirin and blood thinners. The goal was to check for side…

This study looked at 174 adults who had a stroke and were treated under general anesthesia. Researchers compared removing the breathing tube early versus later to see which approach leads to better functional recovery after 90 days. The goal is to find the best ventilation time t…

This study checked how effective and safe a new medical wire, called Tarvos Microguidewire, is during brain blood vessel surgeries. Researchers looked back at records of 121 patients who had the wire used in their procedure. The main goal was to see how often the wire worked as i…

This study looked at whether raising the legs is a safe and practical way to help people who have had a moderate stroke. Fifty adults with stroke were asked to keep their legs elevated for a period of time. The main goal was to see if people could follow the leg-raising plan and …

This study looked back at 481 patients who had a stroke and underwent a procedure to remove a blood clot from their brain. Researchers compared those who received general anesthesia (fully asleep) versus sedoanalgesia (awake but relaxed) to see if one led to better survival and r…

This study looked at 400 people with severe stroke who had a large area of brain damage. All had a procedure to remove a blood clot within 24 hours of symptoms starting. Researchers wanted to find out which factors helped these patients walk independently or survive. The goal is …

This study looked at whether using a balloon-guided catheter is better than a standard one for treating acute ischemic stroke. About 110 adults with stroke in the front part of the brain took part. Researchers measured how well blood flow was restored and checked patients' qualit…

This study tested a new web-based tool designed to help families of patients with severe brain injuries (like stroke or traumatic brain injury) communicate with doctors and make decisions about care goals. The study enrolled 50 family decision-makers to see if the tool was easy t…