Stroke showdown: drug plus procedure vs. procedure alone for basilar artery blockage
NCT ID NCT05631847
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 345 people with a severe stroke caused by a blockage in the basilar artery, a major blood vessel in the brain. It compared two treatments: giving a clot-busting drug followed by a procedure to remove the clot, versus doing the procedure alone. The goal was to see which approach helps more patients recover with little or no disability after 90 days.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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345 people
The number who actually took part.
- Started
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Apr 2023
- Finished
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Aug 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: 1. A clinical diagnosis of AIS. 2. Caused by BAO confirmed by CTA, MRA, or DSA. (BAO is defined as the absence of visualization of the basilar artery on CTA, MRA or DSA. Bilateral vertebral artery occlusions or occlusion of a unilateral vertebral artery that is the sole supplier of the basilar artery, even in the presence of patent basilar artery, will be considered de facto BAO.) 3. CT or MRI ruling out intracranial hemorrhage, 4. Eligible for IVT and EVT (within 4.5 hours of symptom onset). (Symptoms onset is defined as point in time the patient was last seen well \[at baseline\] if patients are unable to provide a reliable history or the point in time when symptoms have started if patients can provide a reliable history. Symptoms onset includes diplopia, midline ataxia, visual loss, sensory or motor deficits, and conscious disturbance. Isolated vertigo \[not accompanied by dysarthria, motor weakness, sensory symptoms, double vision, depressed level of consciousness\] is not considered onset of symptoms.) 5. NIHSS score ≥ 6. 6. Age ≥ 18 years. 7. Signed informed consent by the patient or legal representative. Exclusion criteria: 1. mRS score \> 2 before this stroke. 2. Any contraindication to IVT as per the 2019 AHA/ASA guidelines for early management of AIS: 1\) Blood pressure \> 185/110 mmHg and cannot be controlled by standard medication, 2) Blood glucose \< 50mg/dL (2.8 mmol/L) or \> 400mg/dL (22.2 mmol/L), 3) Had a cerebral infarction in the previous 6 weeks with residual neurological deficit or signs of recent infarction on neuroimaging, 4) Severe head trauma in the previous 3 months, 5) Major surgery or severe trauma in the previous 2 weeks, 6) Gastrointestinal or urinary bleeding in the previous 3 weeks, 7) previous intracranial hemorrhage, 8) Using anticoagulants and International normalized ratio (INR) \> 1.7, 9) Known platelet count \< 100 × 109/L, 10) treatment with direct thrombin or factor X inhibitors, 11) Heparin treatment in the previous 48 hours with the activated partial thromboplastin time (APTT) exceeding the upper limit of normal. (3) Pregnancy, breastfeeding, or intention to conceive during the study period. (4) Other conditions deemed unsuitable by the investigator.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affiliated Hospital of Chengdu Medical College
Chengdu, Sichuan, China
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Affiliated Hospital of North Sichuan Medical College
Nanchong, Sichuan, China
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Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan, China
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Affiliated Traditional Chinese Medicine Hospital of Southwest Hospital Medical University
Luzhou, Sichuan, China
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Anyang People's Hospital
Anyang, Henan, China
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Banan Hospital Affiliated to Chongqing Medical University
Chongqing, Chongqing Municipality, China
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Bazhong Central Hospital
Bazhong, Sichuan, China
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Changde First People's Hospital
Changde, Hunan, China
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Chengdu Fifth People's Hospital
Chengdu, Sichuan, China
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Chengdu First People's Hospital
Chengdu, Sichuan, China
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Chengdu Second People's Hospital
Chengdu, Sichuan, China
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Chengdu Third People's Hospital
Chengde, Sichuan, China
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Chenzhou First People's Hospital
Chenzhou, Hunan, China
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Chongqing Sanbo Chang'an Hospital
Chongqing, Chongqing Municipality, China
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Chongqing University Affiliated S Central Hospital
Chongqing, Chongqing Municipality, China
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Chongqing University Medical University Affiliated Yongchuan Hospital
Chongqing, Chongqing Municipality, China
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Chongqing Yongchuan District People's Hospital
Chongqing, Chongqing Municipality, China
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Chongzhou People's Hospital
Chengdu, Sichuan, China
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Dayi County People's Hospital
Chengdu, Sichuan, China
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Deyang People's Hospital
Deyang, Sichuan, China
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Guang'an Central Hospital
Guang’an, Sichuan, China
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Guanghan People's Hospital
Luocheng, Sichuan, China
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Guangyuan Central Hospital
Guangyuan, Sichuan, China
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Guangyuan First People's Hospital
Guangyuan, Sichuan, China
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Hechuan District People's Hospital
Chongqing, Chongqing Municipality, China
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Heze Municipal Hospital
Heze, Shandong, China
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Huai'an First People's Hospital
Huaian, Jiangsu, China
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Jiaozuo Second People's Hospital
Jiaozuo, Henan, China
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Jilin University Sino Japanese Friendship Hospital
Changchun, Jilin, China
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Jingjiang People's Hospital
Jingjiang, Jiangsu, China
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Jinhua Central Hospital
Jinhua, Zhejiang, China
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Jintang County People's Hospital
Jintang, Sichuan, China
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Langzhong People's Hospital
Nanchong, Sichuan, China
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Leshan People's Hospital
Leshan, Sichuan, China
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Lezhi County People's Hospital
Ziyang, Sichuan, 610000, China
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Liangping District People's Hospital
Chongqing, Chongqing Municipality, China
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Liangshan Prefecture First People's Hospital
Xichang, Sichuan, China
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Liangshan Prefecture Second People's Hospital
Xichang, Sichuan, 610000, China
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Liaocheng Second People's Hospital
Liaocheng, Shandong, China
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Linyi Traditional Chinese Medicine Hospital
Linyi, Shandong, China
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Luoyang Central Hospital
Luoyang, Henan, China
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Maoming County Traditional Chinese Medicine Hospital
Maoming, Guangdong, China
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Meishan Cardiovascular and Cerebrovascular Disease Hospital
Meishan, Sichuan, China
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Meishan Second People's Hospital
Meishan, Sichuan, China
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Meishan Traditional Chinese Medicine Hospital
Meishan, Sichuan, China
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Mianyang 404 Hospital
Mianyang, Sichuan, China
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Mianyang Central Hospital
Mianyang, Sichuan, China
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Mianyang Third People's Hospital
Mianyang, Sichuan, China
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Nanchong Central Hospital
Nanchong, Sichuan, China
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Nanyang Central Hospital
Nanyang, Henan, China
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Nanyang Nanshi Hospital
Nanyang, Henan, China
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Neijiang Second People's Hospital
Neijiang, Sichuan, China
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Pangang Group General Hospital
Panzhihua, Sichuan, China
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Panzhihua Central Hospital
Panzhihua, Sichuan, China
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Pingchang County People's Hospital
Pingchang, Sichuan, China
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Puyang Oilfield General Hospital
Puyang, Henan, China
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Qiandongnan Miao and Dong Autonomous Prefecture People's Hospital
Kaili, Guizhou, China
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Qujing First People's Hospital
Qujing, Yunnan, China
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Rizhao Traditional Chinese Medicine Hospital
Rizhao, Shandong, China
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Shifang People's Hospital
Fangting, Sichuan, China
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Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
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Sichuan Third People's Hospital
Chengdu, Sichuan, 610054, China
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Suining Central Hospital
Suining, Sichuan, China
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Suining First People's Hospital
Suining, Sichuan, China
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Taizhou First People's Hospital
Taizhou, Zhejiang, China
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Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, China
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Taizhou People's Hospital
Taizhou, Jiangsu, China
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The Fifth People's Hospital Affiliated to Southern Medical University
Guangzhou, Guangdong, China
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The First Hospital of Jilin University
Jilin City, Jilin, China
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The First People's Hospital of Liangjiang New Area
Chongqing, Chongqing Municipality, China
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The First People's Hospital of Suqian City
Suqian, Jiangsu, China
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The Second Affiliated Hospital of Shandong First Medical University
Taian, Shandong, China
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Tieling Central Hospital
Tieling, Liaoning, China
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West China Hospital of Sichuan University
Chengdu, Sichuan, 610054, China
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Western Theater General Hospital
Chengdu, Sichuan, China
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Xiangtan Central Hospital
Xiangtan, Hunan, China
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Xiangyang Central Hospital
Xiangyang, Hubei, China
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Xinxiang Central Hospital
Xinxiang, Henan, China
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Xuzhou Medical University Affiliated Hospital
Xuzhou, Jiangsu, China
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Ya'an People's Hospital
Ya'an, Sichuan, China
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Yancheng First People's Hospital
Yancheng, Jiangsu, China
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Yibin First People's Hospital
Yibin, Sichuan, China
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Yibin Second People's Hospital
Yibin, Sichuan, China
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Yilong County People's Hospital
Nanchong, Sichuan, China
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Yingkou Central Hospital
Yingkou, Liaoning, China
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Yongkang First People's Hospital
Guli, Zhejiang, China
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Yuebei People's Hospital
Shaoguan, Guangdong, China
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Yulin First People's Hospital
Yulin, Guangxi, China
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Zhangzhou Hospital
Zhangzhou, Fujian, China
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Zhengzhou Central Hospital
Zhengzhou, Henan, China
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Zhoukou Central Hospital
Zhoukou, Henan, China
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Zhumadian Central Hospital
Zhumadian, Henan, China
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Zigong First People's Hospital
Zigong, Sichuan, China
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Zigong Fourth People's Hospital
Zigong, Sichuan, China
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Zigong Third People's Hospital
Zigong, Sichuan, China
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Ziyang First People's Hospital
Ziyang, Sichuan, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can PET scans reveal hidden heart inflammation after a stroke?
- Can an implanted heart monitor catch hidden irregular heartbeats after stroke?
- China builds national watchdog for brain blood vessel devices
- Can a bedside clotting test predict which brain tumor patients face deadly blood clots?
- Can tiny neural exosomes help the brain heal after a severe stroke?
- Can a new antibody boost recovery after severe stroke?