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Experimental stroke drug shows early safety promise in small trial

NCT ID NCT04677777

First seen Nov 16, 2025 · Last updated May 25, 2026 · Updated 25 times

Summary

This early-stage study tested a new drug called PP-007 in 24 people having an acute ischemic stroke (a stroke caused by a blood clot). Participants received two doses of the drug along with standard treatments like clot-busting medicine or mechanical clot removal. The main goal was to check the drug's safety, including effects on blood pressure, heart rate, bleeding, and other side effects. Researchers also looked at whether the drug improved blood flow to the brain and reduced stroke damage.

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Contacts and locations

Locations

  • Baptist Health Miami Cardiac & Vascular Institute (MCVI)

    Miami, Florida, 33176, United States

  • Baptist Health Research Institute

    Jacksonville, Florida, 32207, United States

  • Emory University School of Medicine

    Atlanta, Georgia, 30303, United States

  • Mercy Health - St. Vincent Medical Center

    Toledo, Ohio, 43608, United States

  • Oregon Stroke Center at Oregon Health & Science University (OHSU)

    Portland, Oregon, 97239, United States

  • Saint Luke's Hospital

    Kansas City, Missouri, 64111, United States

  • UPMC Stroke Institute

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

Conditions

Explore the condition pages connected to this study.