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New hope for stroke patients: which blood thinner works best after emergency treatment?

NCT ID NCT05225961

Disease control Sponsor: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two blood thinners—tirofiban and aspirin—in 240 stroke patients who also had a severe blockage in the neck artery. The goal was to see which drug better prevents the artery from reclosing after emergency surgery, while also checking for bleeding risks. Results will help doctors choose the safest and most effective anti-clotting plan for these complex cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

240 people

The number who actually took part.

Started

Mar 2026

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with acute ischemic stroke of the anterior territory secondary to a tandem lesion, with an indication for thrombectomy treatment according to the current recommendations of the Clinical Practice Guidelines, and the need for cervical stent placement. * The intracranial occlusion locations that may be included are: carotid "T", M1 and M2 segments of the middle cerebral artery, segment A1 of the anterior cerebral artery; and in the case that the posterior cerebral artery has fetal origin and is the site of intracranial occlusion. * ASPECTS (Alberta Stroke Program Early computerized Tomography Score) ≥6. * Greater than or equal to 18 years of age. * Signed informed consent. Exclusion Criteria: * Patients under 18 years of age. * Patients with ASPECTS \<6. * Bilateral strokes or those produced by simultaneous occlusion of an artery in the anterior and posterior territory. * Patients whose carotid stenosis is due to a re-stenosis or reocclusion of a pre-existing cervical stent. * Candidate patients for carotid puncture. * Previous treatment with double antiplatelet therapy for another cause prior to inclusion. * Severe comorbidity and / or reduced life expectancy. * Modified Rankin scale (mRS)\> 2. * Severe allergy to contrast medium. * Pregnant. * Patients with intracranial occlusive arteriosclerotic disease or extra or intracranial dissection. * Documented allergy to acetylsalicylic acid or Tirofiban. * Personal history of platelet penia (Platelets \<100,000) * Concomitant anticoagulant treatment with presence of International Normalized Ratio (INR) \> 1.7 in case of anti-vitamin K treatment or taking direct oral anticoagulant \<48 hours ago) * Medical history of the patient that carries a high risk of bleeding according to the investigator's criteria.

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute ischemic stroke

Contacts and locations

Locations

  • Complejo Hospital Universitario de Badajoz

    Badajoz, Badajoz, Spain

  • Complejo Hospitalario Torrecárdenas

    Almería, Almería, Spain

  • Complexo Hospitalario Universitario A Coruña

    A Coruña, A Coruña, Spain

  • General Hospital Dr. Balmis (Alicante)

    Alicante, Alicante, Spain

  • Germans Trias i Pujol Hospital

    Badalona, Barcelona, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca, Murcia

    Murcia, Murcia, Spain

  • Hospital Universitario de Cruces

    Bilbao, Bilbao, Spain

  • Hospital Universitario y Politécnico de La Fe

    Valencia, Valencia, Spain

  • Josep Trueta Hospital

    Girona, Gerona, Spain

  • Ramón y Cajal Hospital

    Madrid, Madrid, Spain

  • Reina Sofía Hospital

    Córdoba, Córdoba, Spain

  • Virgen Macarena Hospital

    Seville, Seville, Spain

  • Virgen del Rocío Hospital

    Seville, Seville, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.