Massive stroke drug study shows Real-World results

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women aged 18 years and older. * Verified diagnosis of acute ischemic stroke. * The time from the symptoms onset is no more than 4.5 hours. * Thrombolysis with the non-immunogenic staphylokinase, 10 mg as a single intravenous bolus. Exclusion Criteria: * The time from the symptoms onset is more than 4.5 hours or the time of the symptoms onset is unknown. * Increased sensitivity to the non-immunogenic staphylokinase. * Systolic blood pressure above 185 mm Hg or diastolic blood pressure above 110 mm Hg or the need in the drug administration to reduce blood pressure to these levels. * Neuroimaging (CT, MRI) signs of intracranial hemorrhage, brain tumors, arteriovenous malformation, brain abscess, aneurysm of cerebral vessels. * Surgery on the brain or spinal cord. * Suspicion of subarachnoid hemorrhage. * Signs of severe stroke: clinical signs (stroke scale NIH \> 25), neuroimaging (according to CT of the brain and / or MRI of the brain in the DWI, the ischemia focuses on the territory of more than 1/3 of the CMA pool). * Simultaneous reception of oral anticoagulants, for example, warfarin with INR\> 1.3. * The use of direct anticoagulants (heparin, heparinoids) in the preceding stroke of 48 h with APTT values above the norm. * Prior stroke or severe head injury within 3 months. * Significant regression of neurological symptoms during the observation of the patient before thrombolysis. * Hemorrhagic stroke or stroke, unspecified in history. * Strokes of any genesis in the history of a patient with diabetes mellitus. * Gastrointestinal bleeding or bleeding from the genitourinary system in the last 3 weeks. Confirmed exacerbations of gastric ulcer and duodenal ulcer during the last 3 months. * Extensive bleeding now or within the previous 6 months. * Severe liver disease, including liver failure, cirrhosis, portal hypertension (with varicose veins of the esophagus), active hepatitis. * Acute pancreatitis. * Bacterial endocarditis, pericarditis. * Aneurysms of arteries, malformations of arteries and veins. Suspicion of exfoliating aortic aneurysm. * Neoplasms with an increased risk of bleeding. * Large operations or severe injuries within the last 14 days, minor surgery or invasive manipulation in the last 10 days. * Puncture of uncompensated arteries and veins during the last 7 days. * Prolonged or traumatic cardiopulmonary resuscitation (more than 2 min). * Pregnancy, obstetrics, 10 days after birth. * The number of platelets is less than 100,000 / μL. * Blood glucose less than 2.7 mmol / L or more than 22.0 mmol / L. * Hemorrhagic diathesis, including renal and hepatic insufficiency. * Data on bleeding or acute trauma (fracture) at the time of examination. * Seizures in the onset of the disease, if there is no certainty that the seizure is a clinical manifestation of acute ischemic stroke with a postictal residual deficiency.