ACUTE ISCHEMIC STROKE

This study looks at giving an extra dose of the clot-busting drug prourokinase to people having a stroke caused by a medium or large blocked artery. Participants must not have improved much one hour after the first standard treatment. The goal is to see if the second dose can ope…

This study compares a new 'one-stop' emergency stroke unit that combines CT scans and treatment in one room to the usual step-by-step approach. It aims to see if faster diagnosis and treatment helps people with severe strokes recover better and be more independent after 90 days. …

This study tests a rapid procedure called local ischemic postconditioning, done right after doctors remove a blood clot from the brain in people with severe stroke. The goal is to see if it can reduce brain swelling and improve recovery at 90 days. About 448 adults aged 18–85 wit…

This study tests whether the clot-busting drug tenecteplase can help people who have an ischemic stroke and are treated 4.5 to 9 hours after symptoms start. About 564 adults will be randomly assigned to receive either tenecteplase or a placebo, along with standard care. The goal …

This study tests a Chinese herbal medicine called Xinglou Chengqi Granule in 60 people who recently had an acute ischemic stroke. The goal is to find the best dose and see if it helps improve stroke symptoms and daily function. Participants will be monitored for up to 90 days to …

This study tests a nasal spray containing exosomes from human stem cells to see if it is safe and helps people recover from a stroke. The trial includes 60 adults who had a stroke within the last 72 hours. Participants receive either the spray or a placebo, and their recovery is …

This study looks at people who had a major stroke caused by a big clot in a large brain artery. After doctors remove that main clot, some patients still have smaller clots in deeper branches. The trial will randomly assign these patients to either have those small clots removed t…

This study tests whether adding a drug called human urinary kallidinogenase to the standard clot-busting medicine reteplase helps people recover better after an acute ischemic stroke. About 220 adults who can be treated within 4.5 hours of stroke onset will be enrolled. The main …

This study tests whether a clot-dissolving drug called tenecteplase, given directly into the brain artery, can help people who have had a stroke caused by a blockage in a medium-sized blood vessel. About 488 adults will be enrolled within 24 hours of their stroke. The goal is to …

This study will compare the safety of two clot-dissolving medicines, rhTNK-tPA and rt-PA, in about 4,500 adults who have had a stroke. Participants will receive one of the drugs within 4.5 hours of symptoms starting. The main goal is to see if the newer drug, rhTNK-tPA, causes fe…

This study tests whether adding minocycline, an antibiotic that also reduces brain inflammation, improves recovery in people who had a major stroke and underwent successful clot removal. About 860 adults will receive either minocycline or a placebo within 24 hours of stroke onset…

This study tests a mobile app that gives personalized early warnings about temperature-related health risks to people who have had a stroke. The app also helps manage other risk factors. Over 10,000 stroke survivors will use the app or receive standard care, and researchers will …

This study tests whether the drug butylphthalide can reduce brain swelling and improve recovery in people who had a major stroke and underwent a procedure to reopen a blocked artery. About 100 adults will receive either the drug or a placebo. The goal is to see if the drug helps …

This study looks at 2000 people who had a stroke to see which blood thinner (indobufen, aspirin, cilostazol, or clopidogrel) works best to prevent another stroke and has the fewest side effects like bleeding. Researchers will track patients for one year after treatment. The goal …

This study tests a new catheter device designed to remove blood clots from the brain in people having a stroke. About 160 adults will be treated within 24 hours of their first symptoms. The goal is to see if the device can safely restore blood flow and improve outcomes.

This early-phase study tests whether a drug combination (chlorpromazine and promethazine) that induces a hibernation-like state is safe for people having a stroke caused by a blocked artery. About 57 adults aged 18-80 who are eligible for clot-removal treatment will receive the d…

This study looks at whether a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The trial will involve 82 adul…

This study looks at the best way to manage high blood pressure in people having a stroke who are eligible for a clot-busting drug. Currently, doctors lower blood pressure first, then give the drug. This trial tests if giving both treatments at the same time is safer and leads to …

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This study tests whether adding the antibiotic minocycline to standard clot-removal treatment helps people recover better after a severe stroke in the back of the brain. About 234 adults who had a stroke due to a blocked artery and had the clot successfully removed will receive m…

This study tests a clot-dissolving drug called tenecteplase for people who have a stroke but don't know exactly when it started, like waking up with symptoms. About 352 participants will receive either tenecteplase or standard care after a simple CT scan. The goal is to see if th…

This study tests a new drug called RK-4 for people who have had a severe stroke and cannot receive standard clot-removal treatment. The drug is injected directly into the bone marrow of the skull for three days. Researchers want to see if it helps patients recover better and is s…

This study tests whether hyperbaric oxygen (breathing pure oxygen in a pressurized chamber) can help people recover better after a stroke. About 424 adults aged 35-75 who had a stroke and received a procedure to reopen a blocked artery will receive either standard care or standar…

This early study tests if a drug called RK-4 can be safely injected through the skull into the brain for people with a severe stroke. The goal is to see if this method works and is safe for patients who cannot get standard treatments. Only 6 adults aged 18 to 80 with a first-time…

This early-phase study tests an experimental drug called RK-4 in 18 people who have had a severe stroke (large hemispheric infarction) and cannot receive or did not respond to standard clot-removal therapy. The drug is injected directly into the bone marrow of the skull once dail…

This study tests whether giving the drug eptifibatide soon after standard clot-dissolving treatment can help people with acute ischemic stroke recover better. About 786 adults who arrive at the hospital 4.5 to 24 hours after stroke symptoms start will be randomly assigned to rece…

This study tests whether the clot-busting drug tenecteplase can help people who have had a stroke caused by a large blocked artery in the brain, but cannot have a procedure to remove the clot. About 794 adults who had a stroke 4.5 to 24 hours earlier will either get tenecteplase …

This study looks at how well two drugs, edaravone and dexrazoxane, help people recover from a mild to moderate stroke. Researchers will follow 600 adults who had a stroke within the last 48 hours to see if these drugs improve daily functioning and reduce disability. The goal is t…

This study tests a smartphone app that gives personalized tips to stroke survivors. The goal is to see if using the app helps lower the chance of having another stroke within a year. About 5,000 people who recently had a stroke will use the app or get standard care, and researche…

This study tests whether adding the blood thinner tirofiban after standard stroke treatment helps people recover better. About 564 adults who had a stroke from a blocked large artery will be randomly assigned to get tirofiban or usual care. The goal is to see if more people can l…

This study tests whether the drug J147, given by IV along with standard clot-removal therapy, helps people recover better after an ischemic stroke. About 196 participants will receive either J147 or a placebo, and researchers will track safety, brain scans, and functional outcome…

This study tests whether giving a clot-busting drug (rhPro-UK) before a standard clot-removal procedure helps stroke patients recover better. About 820 adults with a large-vessel blockage will receive either the drug or a placebo within 4.5 to 24 hours of their first symptoms. Th…

This study compares two ways to remove large blood clots from the brain in people having a severe stroke. One method uses a super large suction tube, and the other uses a stent-like device to grab the clot. The goal is to see which approach leads to better recovery and less disab…

This study tests whether adding a PCSK9 inhibitor (a cholesterol-lowering drug) to standard care helps people recover better after a stroke caused by a blocked artery. About 478 adults with acute ischemic stroke who undergo endovascular therapy (a procedure to reopen the artery) …

This early-stage study tests the safety of a drug called EMPAVELI in 20 adults who had a stroke from a large blood clot and already had it removed. The drug is given through a pump shortly after the procedure and again at 24 and 48 hours to reduce swelling and inflammation when b…

This study tests whether adding a drug called GM1 to standard clot-removal treatment helps people recover better after a major stroke. About 868 adults with a blocked artery in the front part of the brain will receive either GM1 or a placebo. The goal is to see if more patients c…

This study tests a new catheter device designed to remove blood clots from the brain in people having an acute ischemic stroke. About 45 participants will be treated within 24 hours of their first symptoms. The goal is to see if the device can safely restore blood flow and improv…

This study tests whether giving a clot-preventing drug called tirofiban directly into the brain artery right after a clot is removed can help stroke patients recover better. About 344 adults who had a major stroke from a blocked artery will be randomly assigned to receive either …

This study tests whether adding the drug sivelestat sodium to standard clot-removal surgery helps people recover better from a severe stroke. About 868 adults with a large-vessel blockage in the brain will receive either the drug or a placebo. The goal is to see if the drug reduc…

This study tests a device called I-NIC that uses low-frequency magnetic stimulation to help people recover from a stroke. About 364 participants will receive either the real device or a placebo, along with standard care, for 5 days starting within 48 hours of their stroke. The go…

This study tests a new bedside blood test that may quickly tell if a child is having a stroke. Researchers will check how accurate the test is in 250 children who come to the ER with stroke symptoms. The goal is to speed up diagnosis and treatment, while children still receive st…

This study tests a smartphone app that gives early warnings and advice when temperatures pose a health risk. About 5,000 people who recently had a stroke will use the app for one year. The goal is to see if these alerts help lower the chance of having another stroke.

This study tests whether early brain-computer interface (BCI) training, added to standard rehabilitation, can improve arm and leg movement in people who had a stroke. Sixty adults aged 18 to 80 with arm or leg weakness after clot-busting drugs or mechanical clot removal will be r…

This early-stage trial tests whether a drug called anisodine hydrobromide is safe for people who have had a stroke and are undergoing a procedure to remove a blood clot. The study will include 92 adults aged 18 to 80 with a specific type of stroke. Researchers will monitor for se…

This study looks at how well and how safely a clot-busting drug called tenecteplase works in people aged 80 and older who have had a stroke. Researchers will track recovery and side effects in 392 patients who receive the drug within 4.5 hours of symptoms. The goal is to gather r…

This study aims to validate the Stroke Mimics Score, a tool that uses information collected when a patient arrives at the emergency room to help doctors quickly tell the difference between a real stroke and other conditions that mimic stroke symptoms. Researchers will enroll 1,00…

This study tests an AI system called LingBao that helps doctors make quick, informed decisions about stroke treatments like clot-busting drugs or procedures to remove clots. About 3,000 adults with acute ischemic stroke will take part across 20 hospitals. The goal is to see if us…

This study looks at whether the clot-busting drug tenecteplase is safe and effective for people having a stroke who receive it more than 4.5 hours after symptoms began. Researchers will follow 3,000 patients in China to see how well they recover after 90 days. The goal is to gath…

This study will observe 3,000 stroke patients in China who receive clot-busting medication more than 4.5 hours after their stroke started. The goal is to see how well this late treatment works and how safe it is in everyday hospital settings. Participants must be at least 18 year…

This study looks at whether blood electrolyte levels can predict kidney damage in stroke patients who undergo a clot removal procedure. Researchers will review medical records of 250 adults treated between 2018 and 2026. The goal is to find new ways to identify patients at higher…

This study looks at how changes in the GGCX gene might influence recovery and future health risks after an ischemic stroke. Researchers will collect blood samples from 1,500 stroke patients and follow them for one year to track strokes, bleeding, or death. The goal is to understa…

This study looks at 100 adults who had a stroke caused by a large blood clot in the front part of the brain and underwent a procedure to remove it. Researchers will use a special ultrasound (transcranial Doppler) to measure blood flow in the brain after the procedure. The goal is…

This study looks at a specific type of stroke called Branch Atheromatous Disease (BAD), where a small artery deep in the brain gets blocked. Researchers will compare three treatments: a clot-busting drug (IV thrombolysis), one antiplatelet drug, or two antiplatelet drugs. They wi…