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Hidden stroke subtype gets closer look: do Clot-Busting drugs help?

NCT ID NCT07299994

Knowledge-focused Sponsor: Sigmund Freud PrivatUniversitat Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study reviews past medical records of 462 people who had a stroke caused by branch atheromatous disease (BAD), a blockage in a small, deep brain artery. Researchers want to see if clot-busting drugs (intravenous thrombolysis) work better than antiplatelet medicines (like aspirin or dual therapy) at preventing worsening symptoms and improving recovery. The goal is to provide clearer treatment guidance for this often-overlooked stroke type.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 462 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients with a BAD-related stroke, aged over 18 years, with symptom onset no more than 24 hours before admission, who were treated in one of the stroke units of the participating institutions.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * aged over 18 years, with acute ischemic stroke and symptom onset no more than 24 hours before admission, who were treated in one of the stroke units of the participating institutions. * All enrolled patients must have undergone a cerebral MRI for inclusion: 1. DWI lesion: single isolated deep subcortical stroke AND 2. The affected vessel involves the LSA, PPA, or ACHA, and the infarct lesion on DWI conforms to one of the following characteristics (A, B, OR C): A. LSA: "Comma-like" infarct lesions with "fan-shaped" extension from bottom to top in the coronary position OR ≥ 3 layers (layer thickness 5 mm) on axial DWI. B. PPA: Infarct lesion extending from the deep pons to the ventral pons on axial DWI. C. ACHA: Infarct within the anterior choroidal artery territory. Exclusion Criteria: * Typical recent small subcortical infarction (RSSI) (oval, \<20mm in all axes) * ≥ 50% stenosis on the parent artery (i.e., BA, MCA, or ICA) * Stroke due to other clearly identified causes or possible cardioembolic etiology.

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute ischemic stroke Dapt(dual antiplatelet therapy) Sapt(single antiplatelet therapy) Stroke Thrombolysis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Clinic Favoriten

    RECRUITING

    Vienna, State of Vienna, 1100, Austria

  • Clinic Hietzing

    RECRUITING

    Vienna, State of Vienna, 1130, Austria

  • Department of Neurology & Stroke, University of Tübingen

    RECRUITING

    Tübingen, 72076, Germany

  • Department of Neurology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin

    NOT_YET_RECRUITING

    Berlin, 12200, Germany

  • Department of Neurology, Heidelberg University Hospital

    RECRUITING

    Heidelberg, 69120, Germany

  • Department of Neurology, Medical University of Vienna

    RECRUITING

    Vienna, 1090, Austria

  • Department of Neurology, St. John's Hospital, Vienna, Austria

    RECRUITING

    Vienna, 1020, Austria

  • Department of Neurology, Universityhospital of Bern

    NOT_YET_RECRUITING

    Bern, 3010, Switzerland

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