Yale study to uncover hidden link between blood pressure swings and stroke recovery
NCT ID NCT05756257
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This observational study at Yale University will follow 150 people who have had an ischemic stroke to see how changes in blood pressure affect their recovery. Researchers will use brain scans and thinking tests to understand the connection. The goal is to find better ways to manage blood pressure after a stroke.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could point toward new ways to manage blood pressure after a stroke to improve recovery and reduce disability.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly test any therapy. Results may not lead to immediate changes in care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2024
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with acute ischemic stroke serve as the source population for the study and will be identified as inpatients at participating centers.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ischemic stroke according to the American Heart Association (AHA) definition and either: 1. CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or 2. Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA) Onset of ischemic stroke within 48 hours and able to get baseline pMRI within 72 hours of arrival 4\) NIH Stroke Scale ≥ 4 at time of enrollment Exclusion Criteria: * Pre-morbid mRS ≥3 * Predicted hospital system admission \<72 hours * Pacemaker or other MRI contraindications per American College of Radiology guidelines
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
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Yale-New Haven Hospital
RECRUITINGNew Haven, Connecticut, 06510, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can an implanted heart monitor catch hidden irregular heartbeats after stroke?
- China builds national watchdog for brain blood vessel devices
- Can tiny neural exosomes help the brain heal after a severe stroke?
- Can a new antibody boost recovery after severe stroke?
- After stroke, a balloon or a stent? trial tests which rescue opens blocked brain arteries better