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Can a blood pressure cuff on your arm help your brain heal after a stroke?

NCT ID NCT06559241

Disease control Sponsor: Capital Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a noninvasive arm cuff therapy, called remote ischemic conditioning, can improve recovery in people who have had a major stroke and undergone a clot-removal procedure. The therapy involves briefly inflating and deflating a cuff on the upper arm to protect the brain from further damage. About 2105 participants will receive the therapy for either 14 or 30 days, and their functional outcomes will be measured at 90 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remote ischemic conditioning (arm cuff device)
What this could lead to
If it works, this simple, noninvasive therapy could significantly improve functional recovery and reduce disability after a major stroke.
What could go wrong
This is a large Phase 3 trial, but earlier studies were small. The therapy may not provide meaningful benefit over standard care, and results may not apply to all stroke types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 2,105 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age≥18 years； 2. Acute ischemic stroke due to large vessel occlusion in the anterior circulation that is not suitable for intravenous thrombolytic therapy, or has contraindications to intravenous thrombolytic therapy, or treated with intravenous thrombolytic therapy without recanalization; 3. Large vessel occlusion confirmed by computed tomography angiography (CTA) or magnetic resonance angiography (MRA), including the occlusion of the intracranial segment of the internal carotid artery (ICA) and M1 segment of the middle cerebral artery (MCA), is the cause of symptoms, and mechanical thrombectomy is planned within 24 hours from the time last known well; 4. Baseline score of the National Institutes of Health Stroke Scale (NIHSS) ≥ 6 points; 5. Patients or family members signed a written informed consent form. Exclusion Criteria: 1. Imaging examination revealed the presence of multiple vascular supply areas of cerebral infarction (such as the simultaneous presence of infarction in both anterior and posterior circulation); 2. Absence of femoral artery pulsation, extremely difficult intravascular access, or extremely tortuous large vessels, which are expected to result in the inability to undergo timely endovascular treatment; 3. Difficult-to-control hypertension: continuous monitoring upon admission shows systolic blood pressure ≥180mmHg, or diastolic blood pressure ≥100mmHg; 4. Coma or lethargy patients (consciousness level score ≥2 in NIHSS); 5. Unable to obtain an accurate baseline NIHSS score; 6. Pre-stroke modified Rankin Scale (mRS) score \>1; 7. Baseline ASPECTS score ≤5; 8. Presence of bleeding tendency, deficiency of coagulation factors, or oral anticoagulant therapy with INR \> 3.0; 9. Baseline blood glucose \<2.7mmol/L or \>22.2mmol/L; 10. Baseline platelet count \< 30\*10\^9/L; 11. Severe known renal impairment defined as requiring dialysis (hemodialysis or peritoneal dialysis), or if known creatinine clearance rate \<30mL/min; 12. Cranial CT or MRI shows intracranial hemorrhage; 13. Cranial CT or MRI shows midline deviation and significant occupying effect; 14. Clinical history, previous imaging examinations, or clinical judgment suggesting intracranial tumors, arteriovenous malformations, or intracranial arterial dissection; 15. History of head injury in the past 3 months; 16. History of life-threatening allergy to contrast agents, nickel, titanium metal, or their alloys; 17. Pregnancy, if women of childbearing age have a positive urinary or serum β-human chorionic gonadotropin (β-hCG) test or are breastfeeding； 18. The life expectancy of patients is less than 6 months, and they cannot be evaluated within 3 months; 19. Limb deformity, soft tissue injury, or other conditions that affect the implementation of distant ischemia adaptation therapy; 20. Participating in other ongoing clinical trials; 21. Other conditions that the investigators believe are not suitable for participation in this study.

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Conditions

The condition(s) this trial relates to.

brain infarction cerebral infarction ischemic stroke large artery stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute ischemic stroke Anterior circulation brain infarction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    56 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aerospace Central Hospital

    RECRUITING

    Beijing, 100049, China

  • Anshan Changda Hospital

    RECRUITING

    Anshan, Liaoning, Anshan, China

  • Army Medical University Noncommissioned Officer School Affiliated Hospital

    RECRUITING

    Shijiazhuang, Hebei, 050047, China

  • Beijing Chao-Yang Hospital

    RECRUITING

    Beijing, 100020, China

  • Beijing Daxing District People's Hospital

    RECRUITING

    Beijing, 102600, China

  • Beijing Fangshan District First Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100010, China

  • Beijing Fengtai You'anmen Hospital

    RECRUITING

    Beijing, 100071, China

  • Beijing Luhe Hospital affiliated to Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, 100000, China

  • Beijing Red Cross Emergency Medical Center

    RECRUITING

    Beijing, 100085, China

  • Cangzhou Central Hospital

    RECRUITING

    Cangzhou, Hebei, 061000, China

  • Chongqing University Fuling Hospital

    NOT_YET_RECRUITING

    Chongqing, 408000, China

  • Dalian Central Hospital

    NOT_YET_RECRUITING

    Dalian, Liaoning, 116000, China

  • Feixian People's Hospital

    SUSPENDED

    Linyi, Shandong, 273400, China

  • First People's Hospital of Tianmen

    SUSPENDED

    Tianmen, Hubei, 430000, China

  • Fujian Provincial Hospital

    NOT_YET_RECRUITING

    Fuzhou, Fujian, 350028, China

  • Hebei General Hospital

    NOT_YET_RECRUITING

    Shijiazhuang, Hebei, 455001, China

  • Henan Province People's Hospital

    NOT_YET_RECRUITING

    Zhengzhou, Henan, 450000, China

  • Huanggang Central hospital

    RECRUITING

    Huanggang, Hubei, 438000, China

  • Huangshi central hospital

    RECRUITING

    Huangshi, Hubei, 435000, China

  • Inner Mongolia Autonomous Region People's Hospital

    NOT_YET_RECRUITING

    Hohhot, Inner Mongolia, 010000, China

  • Jiaozuo Coal Industry Group Co., Ltd. Central Hospital

    RECRUITING

    Jiaozuo, Henan, 454000, China

  • Jinan Third People's Hospital

    RECRUITING

    Jinan, Shandong, 250000, China

  • Jingmen Central hospital

    RECRUITING

    Jingmen, Hubei, 448000, China

  • Jingmen People's Hospital

    RECRUITING

    Jingmen, Hubei, 448000, China

  • Liaocheng People's Hospital

    RECRUITING

    Liaocheng, Shandong, 252000, China

  • Liaocheng Third People's Hospital

    RECRUITING

    Liaocheng, Shandong, 252000, China

  • Luoyang Yanshi People's Hospital

    RECRUITING

    Luoyang, Henan, 471000, China

  • Mianyang third people's hospital

    RECRUITING

    Mianyang, Sichuan, 621000, China

  • Nanyang Central Hospital

    RECRUITING

    Nanyang, Henan, 473000, China

  • Shengli Oilfield Central Hospital

    RECRUITING

    Dongying, Shandong, 257000, China

  • Shenzhen Second People's Hospital

    NOT_YET_RECRUITING

    Shenzhen, Guangdong, 518000, China

  • South China Hospital Affiliated to Shenzhen University

    RECRUITING

    Shenzhen, Guangdong, 518000, China

  • Suzhou Municipal Hospital of Anhui Province

    RECRUITING

    Suzhou, Anhui, 234000, China

  • Taihe County People's Hospital

    RECRUITING

    Taihe Chengguanzhen, Anhui, 236600, China

  • The Central Hospital of Xiangtan

    NOT_YET_RECRUITING

    Xiangtan, Hunan, 411100, China

  • The First Affiliated Hospital of Dalian Medical University

    RECRUITING

    Dalian, Liaoning, 116000, China

  • The First Affiliated Hospital of Soochow University

    RECRUITING

    Suzhou, Jiangsu, 215006, China

  • The Fourth Affiliated Hospital of Soochow University

    RECRUITING

    Suzhou, Jiangsu, 215000, China

  • The Hongda Hospital of Jiamusi University

    RECRUITING

    Jiamusi, Heilongjiang, 154000, China

  • The People's Hospital of Gaotang

    RECRUITING

    Liaocheng, Shandong, 252800, China

  • The Second Affiliated Hospital of Wenzhou Medical University

    RECRUITING

    Wenzhou, Zhejiang, 325000, China

  • The Second Nanning People's Hospital

    RECRUITING

    Nanning, Guangxi, 530000, China

  • The Third People's Hospital of Hubei Province

    NOT_YET_RECRUITING

    Wuhan, Hubei, 430033, China

  • The Third Xiangya Hospital of Central South University

    RECRUITING

    Changsha, Hunan, 410000, China

  • Tongling People's Hospital

    RECRUITING

    Tongling, Anhui, China

  • Xihua county people's hospital

    RECRUITING

    Zhoukou, Henan, 466600, China

  • Xuanwu Hospital, Capital Medical University

    RECRUITING

    Beijing, 100053, China

  • Xunxian People's Hospital

    RECRUITING

    Hebi, Henan, 456250, China

  • Ya 'an People's Hospital

    RECRUITING

    Ya'an, Sichuan, 625000, China

  • Yeda Hospital

    RECRUITING

    Yantai, Shandong, China

  • Yichang Central People's Hospital

    RECRUITING

    Yichang, Hubei, 443000, China

  • Yueqing People's Hospital

    RECRUITING

    Yueqing, Zhejiang, 325600, China

  • Zhangzhou Municipal Hospital of Fujian Province

    RECRUITING

    Zhangzhou, Fujian, 363000, China

  • Zhongnan Hospital of Wuhan University

    RECRUITING

    Wuhan, Hubei, 430000, China

  • the First People's Hospital of Changde

    RECRUITING

    Changde, Hunan, 415000, China

  • the First People's Hospital of Chenzhou

    NOT_YET_RECRUITING

    Chenzhou, Hunan, 423000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.