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Why do some stroke patients not improve after clot removal? new study aims to find out

NCT ID NCT07534319

Knowledge-focused Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why about half of stroke patients don't recover well even after doctors successfully remove a blood clot from their brain. Researchers will use special MRI scans to measure blood flow changes in the brain at 3 days, 7 days, and 90 days after the procedure. They will follow 100 adult stroke patients to see if these blood flow patterns relate to how well patients recover 3 months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify why some stroke patients don't recover well after clot removal, potentially leading to better treatments.
What could go wrong
This is an early observational study with only 100 participants, so results may not apply to all patients. It aims to understand the problem, not test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with an acute ischemic stroke of the ICA, MCA or with tandem occlusion who have had a successful recanalization, defined as mTICI score ≥2b and with written informed consent of the patient or a family member

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female subjects \>18 years old. * Acute ischemic stroke related to a new occlusion of the internal carotid artery, middle cerebral artery (M1- and/or M2-segment), or both. * Eligibility and performance of endovascular thrombectomy. * Achievement of successful recanalization, defined as mTICI score ≥2b * Written informed consent of the patient or when the patient is not able to participate in the consenting procedure, the written authorization of a family member. Foreign speaking patients should be included by a person with sufficient German language proficiency to act as a translator. Exclusion Criteria: * Documented evidence or a confirmed willingness of the patient not to participate in any scientific study. * Standard contraindications for MRI, such as pacemaker, metallic prothesis, glaucoma, metallic tattoo dyes, verbal confirmed pregnancy. Unwilling or unable to cooperate with breathing manoeuvres. * Major cardiopulmonary diseases, such as severe uncontrolled asthma bronchiale, severe chronic obstructive lung disease (i.e., GOLD stage ≥III), diffuse interstitial lung disease, pulmonary embolism, acute/subacute myocardial infarction, or severe heart failure (i.e., NYHA class ≥III). * Symptomatic increased intracranial pressure. * Presence of intracranial haemorrhage type ≥2 according to the Heidelberg classification. * New onset of seizure.

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Conditions

The condition(s) this trial relates to.

ischemic stroke No-Reflow Phenomenon stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute cerebrovascular accident Cerebral revascularization No-reflow phenomenon Thrombectomy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Zurich University Hospital

    RECRUITING

    Zurich, Canton of Zurich, 8006, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.