Heart attack patients under 60 get genetic screening for hidden cholesterol disorder

NCT ID NCT05218005

Diagnosis Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether offering genetic screening to younger heart attack patients (under 60) can uncover hidden cases of Familial Hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Researchers recruited 140 patients admitted with a heart attack and performed a research-based genetic test for FH. The goal was to see if this approach leads to more diagnoses and better cholesterol management after the heart attack.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Research-based genetic test for Familial Hypercholesterolemia
What this could lead to: If successful, this approach could help identify more people with a genetic cause of high cholesterol after a heart attack, leading to better treatment and prevention of future events.
What could go wrong: This is a small, completed study focused on diagnosis, not a treatment trial. It may not show that genetic testing improves long-term outcomes, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

140 people

The number who actually took part.

Started

Jan 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. Age \<60 years AND 2. Admitted to an acute cardiac unit with either: * A ST elevation myocardial infarction (STEMI), or * A non-ST elevation myocardial infarction (NSTEMI) AND 3. Maximum lipid level at the time of admission or during the prior 1 year of * LDL level ≥4 mmol/L (154 mg/dL) if not on a statin, or * LDL-C level ≥2.5 mmol/L (96 mg/dL) if on a statin prior to presentation, or * Non-HDL-C ≥4.6 mmol/L (177 mg/dL)

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome acute subendocardial myocardial infarction familial hypercholesterolemia hypercholesterolemia, autosomal dominant, type B hypercholesterolemia, familial, 1 hyperlipoproteinemia type 3 Hyperlipoproteinemia Type II Hyperlipoproteinemia Type III myocardial infarction Non-ST Elevated Myocardial Infarction ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute coronary syndrome Familial hypercholesterolemia Familial hypercholesterolemia - heterozygous Familial hypercholesterolemia due to genetic defect of apolipoprotein B Familial hypercholesterolemia due to heterozygous LDL receptor mutation Familial hypercholesterolemia with hyperlipemia Nstemi - non-ST segment elevation mi STEMI

Heart attack patients under 60 get genetic screening for hidden cholesterol disorder

What the study statuses mean