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Brain pressure may fuel heart rhythm problems in heart failure patients

NCT ID NCT07521293

Knowledge-focused Sponsor: Ankara Ataturk Sanatorium Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart function. They found that higher brain pressure and venous congestion were independently tied to atrial fibrillation, suggesting a possible heart-brain connection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If confirmed, this could point to new ways to predict or prevent atrial fibrillation in people with heart failure.
What could go wrong
This is an observational study, not a treatment trial. It shows associations, not cause and effect, and needs further validation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

309 people

The number who actually took part.

Started

Oct 2025

Finished

Mar 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

A total of 309 subjects aged approximately 60-78 years with available cranial MRI data were enrolled, including a control group (n = 106), HFpEF patients in sinus rhythm (n = 111), and HFpEF patients with atrial fibrillation (n = 92).

Ages

60 to 78 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adults aged approximately 60-78 years with available cranial MRI , HFpEF patients in sinus rhythm, HFpEF patients with atrial fibrillation No HFpEF patients(control) - Exclusion Criteria: Patients with heart failure and reduced ejection fraction (EF \<50%), known intracranial hypertension, optic nerve or other neurological disorders, chronic obstructive pulmonary disease, clinically significant goiter, liver cirrhosis, renal failure, severe valvular heart disease, congenital heart disease, and advanced diabetes mellitus requiring insulin therapy \-

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Conditions

The condition(s) this trial relates to.

atrial fibrillation diastolic heart failure Hyperemia intracranial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation Heart failure with preserved ejection fraction (hfpef) Intracranial pressure Optic nerve sheath diameter Venous congestion

Contacts and locations

Locations

  • Ankara Ataturk Strh

    Ankara, Ankara, 06310, Turkey (Türkiye)

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