Heart failure with preserved ejection fraction (hfpef
Clinical trials for Heart failure with preserved ejection fraction (hfpef explained in plain language.
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New nerve treatment could ease heart failure symptoms
Disease control Recruiting nowThis study tests a procedure that uses a catheter to treat a nerve in the body, aiming to improve symptoms in people with a type of heart failure called HFpEF. About 150 participants will be enrolled to see if the procedure is safe and effective. The goal is to help patients feel…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: Axon Therapies, Inc. • Aim: Disease control
Last updated Sep 21, 2026 22:00 UTC
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Can a new pill ease the burden of heart failure with preserved pumping?
Disease control Recruiting nowThis phase 3 trial is testing whether an experimental drug called elecoglipron can reduce serious heart failure events, such as hospitalizations or urgent visits, in adults with heart failure with preserved or mildly reduced ejection fraction. Participants will receive either ele…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Phase 3 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Could a smarter pacemaker ease a common type of heart failure?
Disease control Recruiting nowThis study tests whether a pacemaker programmed to each person's needs can improve symptoms and outcomes for people with a common type of heart failure (HFpEF). About 700 adults with heart failure but normal pumping strength will receive either personalized pacing or minimal/no p…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: Medtronic Cardiac Rhythm and Heart Failure • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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New pill for stiff heart condition enters human testing
Disease control Recruiting nowThis early-stage trial tests a new drug called VS-041 in 42 people aged 50 and older who have a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The main goals are to check if the drug is safe and to measure changes in certain blood markers linked to…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Phase 1 • Sponsor: Vasa Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Heart failure patients with AF: which treatment works best?
Disease control Recruiting nowThis study tests two ways to manage atrial fibrillation in people with heart failure: using a procedure called catheter ablation to restore normal rhythm, or using medications to control heart rate. About 84 participants will be randomly assigned to one of these approaches. The g…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: Nova Scotia Health Authority • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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New imaging techniques aim to catch hidden heart failure
Diagnosis Recruiting nowThis study looks at whether advanced heart scans (echocardiogram and MRI) can help diagnose a type of heart failure called HFpEF, where the heart is stiff but pumps normally. Standard tests often miss it, leaving many without proper treatment. Researchers will study 40 adults wit…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust • Aim: Diagnosis
Last updated Jun 27, 2026 11:02 UTC
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Strength before cardio: new exercise strategy tested for heart patients
Symptom relief Recruiting nowThis study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. Instead of starting with aerobic exercise like walking, participants will first do 2 months of progressive re…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: Northwestern University • Aim: Symptom relief
Last updated Aug 26, 2026 00:00 UTC
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Heart stent study aims to ease stiff heart symptoms
Symptom relief Recruiting nowThis study looks at whether placing stents in blocked heart arteries can improve quality of life for people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle is stiff. About 350 participants will be randomly assigned to receive either…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Phase 2 • Sponsor: King's College London • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Can tiny heart vessel damage predict heart failure?
Knowledge-focused Recruiting nowThis study looks at how small vessel disease—narrowing of the tiny arteries in the heart—might contribute to a condition called pre-heart failure with preserved ejection fraction (pre-HFpEF), where the heart muscle doesn't relax properly despite pumping normally. Researchers will…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: Cedars-Sinai Medical Center • Aim: Knowledge-focused
Last updated Aug 28, 2026 00:00 UTC
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Can Omega-3s cool inflammation in stiff hearts?
Knowledge-focused Recruiting nowThis early-phase study is testing whether omega-3 fatty acids can reduce inflammation in the heart muscle of people with heart failure with preserved ejection fraction (HFpEF). Researchers will use special MRI scans before and after an iron-based infusion to detect changes in inf…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Early phase 1 • Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Could belly fat around the heart be making your heart failure worse?
Knowledge-focused Recruiting nowThis study is recruiting 130 people with heart failure with preserved ejection fraction (HFpEF), both obese and non-obese. Researchers will use CT and MRI scans, blood tests, and other checks to see if having more fat around the heart leads to worse heart function. The goal is to…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: University of Leicester • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Mobile MRI vans hunt for silent heart failure in city dwellers
Knowledge-focused Recruiting nowThis study will use a mobile MRI truck to screen 600 people in large German cities who have risk factors like diabetes, high blood pressure, or obesity but no heart failure symptoms. The goal is to find out how many have hidden (stage B) heart failure. Results will be compared to…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: German Heart Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Smart watch study aims to cut heart failure hospitalizations by 20%
Knowledge-focused Recruiting nowThis study is testing whether a special wearable device, combined with artificial intelligence, can help people with chronic heart failure avoid hospital visits. About 205 adults will wear the device for six months while their health data is monitored remotely. The goal is to see…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: University of Salerno • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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1,250 patients join quest to unlock secrets of stubborn heart failure
Knowledge-focused Recruiting nowThis study follows 1,250 people with a type of heart failure called HFpEF, where the heart doesn't pump blood properly. Researchers will collect routine medical information to better understand why HFpEF develops, find new tests, and learn about life expectancy. No new treatments…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: Manchester University NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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New study links heart blood flow and body fat to exercise capacity in heart failure
Knowledge-focused Recruiting nowThis study looks at how blood flow in the heart's small vessels and body composition (muscle vs. fat) affect exercise ability in people with a type of heart failure called HFpEF. Researchers will measure heart blood flow using ultrasound and body composition with a special scale,…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF
Sponsor: Korea University Anam Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:53 UTC