New imaging techniques aim to catch hidden heart failure
NCT ID NCT06905405
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether advanced heart scans (echocardiogram and MRI) can help diagnose a type of heart failure called HFpEF, where the heart is stiff but pumps normally. Standard tests often miss it, leaving many without proper treatment. Researchers will study 40 adults with symptoms like breathlessness but unclear diagnoses, using imaging to find signs of HFpEF and then start treatment if needed.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients who have been referred to a cardiology clinic with symptoms that may be suggestive of HFpEF, such as breathlessness or fluid overload, but who didn't meet the criteria for diagnosis based on standard imaging.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female \> 18yrs of age. * Symptoms of dysponea on exertion. * NTproBNP \>400 ng/L in sinus rhythm (SR). * Baseline TTE demonstrating a dilated LA (LA\>34 ml/m2), but that otherwise does not meet the current criteria for the diagnosis of HFpEF or HFrEF (preserved LV systolic function, Normal E/e', no evidence of LVH, Estimated PAP \< 35mmhg). Exclusion Criteria: * Inability to give informed consent. History of HFrEF * contraindications to SGLT2 inhibitor (a history of type 1 diabetes mellitus, ketoacidosis, allergy to SGLT2 inhibitors, planned or current use of SGLT2 inhibitors or active genital infection). * Atrial Fibrillation. * Current history of anginal chest pain
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Sheffield Teaching Hospitals NHS Foundation Trust
RECRUITINGSheffield, South Yorkshire, S5 7AU, United Kingdom
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University of Sheffield
NOT_YET_RECRUITINGSheffield, S10 2TN, United Kingdom
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Other studies related to the condition(s) this trial covers.
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- Can tiny heart vessel damage predict heart failure?
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- Iron and folic acid: a simple pill that could ease anemia and heart symptoms?
- Iron showdown: IV vs. pills for heart failure fatigue