Could a smarter pacemaker ease a common type of heart failure?

NCT ID NCT06678841

Recruiting now Disease control Sponsor: Medtronic Cardiac Rhythm and Heart Failure Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 19, 2026 · Updated 30 times

Summary

This study tests whether a pacemaker programmed to each person's needs can improve symptoms and outcomes for people with heart failure with preserved ejection fraction (HFpEF). About 700 adults with HFpEF will either receive personalized pacing or minimal/no pacing. The goal is to see if this approach reduces heart failure events, improves quality of life, and is safe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Banner - University Medical Center Phoenix
RECRUITING

Phoenix, Arizona, 85006, United States
CHU Toulouse - Hôpital Rangueil
RECRUITING

Toulouse, 50032, France
Cardiovascular Institute of Northwest Florida
RECRUITING

Panama City, Florida, 32405, United States
Cardiovascular Institute of the South
RECRUITING

Houma, Louisiana, 70360, United States
Centre Hospitalier Universitaire Besancon - Hôpital Jean Minjoz
RECRUITING

Besançon, 25030, France
Centre Hospitalier Universitaire de Clermont-Ferrand - Gabriel-Montpied
RECRUITING

Clermont-Ferrand, 63003, France
Charleston Area Medical Center (CAMC) Memorial Hospital
RECRUITING

Charleston, West Virginia, 25304, United States
Dallas VA Medical Center
RECRUITING

Dallas, Texas, 75216, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory University
RECRUITING

Atlanta, Georgia, 30308, United States
Fakultni nemocnice Královské Vinohrady
RECRUITING

Prague, 100 34, Czechia
Froedtert Hospital
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06106, United States
Hôpitaux Universitaires de Genève
RECRUITING

Geneva, 1205, Switzerland
Inova Fairfax Hospital
RECRUITING

Falls Church, Virginia, 22042, United States
Kokura Memorial Hospital
RECRUITING

Kitakyushu, Fukuoka, 802-8555, Japan
Lancaster General Hospital
RECRUITING

Lancaster, Pennsylvania, 17602, United States
Lankenau Institute for Medical Research
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
M Health Fairview University of Minnesota Medical Center - East Bank
RECRUITING

Minneapolis, Minnesota, 55455, United States
Manchester University NHS Foundation Trust - Manchester Royal Infirmary
RECRUITING

Manchester, M13 9WL, United Kingdom
Medical University of South Carolina (MUSC)
RECRUITING

Charleston, South Carolina, 29425, United States
Mount Carmel East
RECRUITING

Columbus, Ohio, 43219, United States
Norton Healthcare
RECRUITING

Louisville, Kentucky, 40295, United States
Ordensklinikum Linz GmbH / Elisabethinen
RECRUITING

Linz, 4010, Austria
Oslo Universitetssykehus-Rikshospitalet
RECRUITING

Oslo, 0372, Norway
Prince of Wales Hospital
RECRUITING

Hong Kong, Hong Kong
Queen Elizabeth Hospital (Hong Kong)
RECRUITING

Hong Kong, Hong Kong
Saint Lukes Mid America Heart Institute
RECRUITING

Kansas City, Missouri, 64111, United States
Saint Pauls Hospital
RECRUITING

Vancouver, V6Z 1Y6, Canada
Saint Thomas Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Sarawak Heart Centre
RECRUITING

Kota Samarahan, 94300, Malaysia
Sutter Health Hospital
RECRUITING

San Francisco, California, 94107, United States
Texas Health Research & Education Institute
RECRUITING

Fort Worth, Texas, 76104, United States
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Leeds Teaching Hospitals NHS Trust - Leeds General Infirmary
RECRUITING

Leeds, LS1 3EX, United Kingdom
The Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
The Prince Charles Hospital
RECRUITING

Chermside, Queensland, 4032, Australia
The University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
The University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
Universitair Ziekenhuis Antwerpen
RECRUITING

Edegem, 2650, Belgium
University Medical Centre Ljubljana
RECRUITING

Ljubljana, 1000, Slovenia

Conditions

Explore the condition pages connected to this study.

HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)