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Half the heparin, less bleeding? new study tests safer heart surgery

NCT ID NCT00657475

Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and compared the half dose to the standard dose, using a special mini heart-lung machine. The goal was to see if the lower dose could make surgery safer without raising the risk of clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

238 people

The number who actually took part.

Start date

Jun 2008

Finished

Mar 2013

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * single or multiple coronary bypass * written and informed consent * repair or replacement of artic leaflet * platelet suppressive agents stopped since at least 7 days * anticoagulants stopped since at least 3 days Exclusion Criteria: * Thoracic surgery antecedent * ASA 4 * carotid stenosis \> 75% * Hb \< 10,5 g/l * chronic hepatic failure * thromboembolic antecedent

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Conditions

The condition(s) this trial relates to.

aortic valve disorder aortic valve stenosis coronary artery disorder Hemorrhage Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery Extracorporeal circulation

Contacts and locations

Locations

  • Cardiac Surgery Dpt (University Hospital)

    Bordeaux, 33000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.