Heart disorder

This study tests whether using urine sodium levels to guide diuretic dosing improves outcomes for emergency department patients with acute heart failure. About 474 adults with fluid overload will be randomly assigned to either the urine-guided protocol or standard care. The goal …

This study tests a temporary heart pump called Impella ECP in 100 adults undergoing high-risk angioplasty. The pump helps maintain blood flow during the procedure. Researchers are checking if the device is safe and works as intended, with follow-up for 30 days after the procedure…

This early study is testing a device that uses ultrasound to ablate (calm) nerves in the pulmonary artery. The goal is to see if this procedure can improve quality of life for 50 people with heart failure and a specific type of pulmonary hypertension (Group 2). Participants will …

This early study tests a new catheter technique called VINTAGE for people with ventricular arrhythmia that hasn't improved with standard treatment. The procedure uses special catheters to reach and destroy heart tissue causing the abnormal rhythm. Thirty adults will be enrolled a…

This study tests a special balloon coated with a drug to treat heart arteries that have narrowed again after a stent was placed. About 600 adults with this condition will be randomly assigned to receive either the drug-coated balloon or a standard balloon procedure. The goal is t…

This early study tests a new device (LAmbre II) that closes a small pouch in the heart called the left atrial appendage in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. Ten participants will be followed for abo…

This study tests a new treatment called cipaglucosidase alfa/miglustat in children (0 to under 18 years) with late-onset Pompe disease. The goal is to see if it is safe and how well it works. Participants either have never had enzyme therapy before or have been on it for at least…

This study tests whether Empagliflozin (Jardiance), a drug used for diabetes and heart failure, can help adults born with heart defects who now have a weakened heart. Forty participants will receive either the drug or a placebo for one year. Researchers will measure changes in he…

Researchers compare two timings for giving the blood thinner heparin during minimally invasive heart procedures that require a puncture through the wall between the heart's upper chambers. Adults scheduled for mitral valve repair or left atrial appendage closure join the trial. O…

This study tests a special balloon coated with the drug paclitaxel to treat in-stent restenosis, where a previously placed stent in a heart artery narrows again. Twenty adults who have this condition will receive the balloon treatment or standard care. Researchers will check if t…

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This early study is testing a new device called the DurAVR™ THV System, which is a replacement heart valve placed through a small tube in the leg (TAVI procedure). The study includes 40 people with severe aortic stenosis or a failed surgical valve. The main goal is to see if the …

This study tested a new device called the ACURATE neo2, which replaces a narrowed heart valve without open-heart surgery. About 1,900 people with severe aortic stenosis received either the new device or a standard one. The goal was to see if the new device is safe and works as we…

This phase 4 study tests the drug mavacamten in 63 adults with a type of heart muscle disease called obstructive hypertrophic cardiomyopathy. The goal is to see if the drug can improve heart structure, measured by MRI, and ease symptoms like shortness of breath. Participants take…

This international registry study looks at a small device called a transcatheter pulmonary flow restrictor, which doctors implant in the lung arteries of young children with congenital or acquired heart disease. The goal is to see whether the device safely and effectively control…

This study tests a new device that replaces a leaky tricuspid heart valve using a thin tube inserted through a leg vein, avoiding open-heart surgery. It includes 150 people with severe tricuspid regurgitation who are too high-risk for surgery. The goal is to see if the device is …

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This study tests a drug called mavacamten in 132 people with hypertrophic cardiomyopathy (thick heart muscle) that blocks blood flow in the middle or tip of the heart's main pumping chamber. The goal is to see if mavacamten can reduce the pressure difference across the blockage a…

Researchers compare two common procedures for people with severely blocked coronary arteries and a heart that pumps poorly. One group receives coronary artery bypass graft surgery, and the other receives percutaneous coronary intervention, also known as stenting. The study tracks…

BP-REACH tests whether a team-based program can help people who have had a stroke or heart attack lower their blood pressure. Participants receive a home blood pressure monitor, self-management education, monthly coaching calls, and medication management from a pharmacist. Resear…

This study follows 300 people with blocked leg arteries who received a treatment using a balloon coated with paclitaxel and vitamin E. The goal is to see if the balloon keeps the artery open and prevents the need for repeat procedures over one year. Participants are adults with m…

This study tests a new device called the Navitor TAVI system to replace a stiff, narrowed heart valve without open-heart surgery. It includes 1,500 people with severe aortic stenosis who are at low or intermediate risk for surgery. The goal is to see if the device is safe and eff…

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This study tests a new system that combines a leadless pacemaker with a subcutaneous defibrillator to treat dangerously fast heart rhythms. The devices communicate wirelessly to deliver pacing therapy without wires inside the heart. About 300 people at risk for ventricular tachyc…

This study tests a new device called the VariPulse catheter, which uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. Twenty adults with AF will get this treatment, and after 2-3 months, doctors will check if the treated veins are still…

This study is testing a new device called the Cephea Mitral Valve System for people with mitral valve disease (leaky or narrowed heart valves) who cannot have open-heart surgery. The goal is to see if the device is safe and works well. About 20 people will take part.

This study compares two ways to fix a leaky mitral valve in people aged 60 and older: a less invasive procedure using a clip (TEER) versus traditional open-heart surgery. About 450 participants will be randomly assigned to one of the two treatments. The goal is to see if the clip…

This study looks at people with severe aortic stenosis (a narrowed heart valve) who don't yet have symptoms. Doctors usually wait until symptoms appear before replacing the valve, but by then the heart may already be damaged. The researchers use MRI scans to find hidden scarring …

This study tests whether a temporary heart pump can help high-risk patients during coronary stenting. The pump supports the heart's main chamber during the procedure, aiming to prevent heart failure or death. About 300 patients with severe coronary disease and weak heart muscle w…

This study follows 17 people with Pompe disease who have already taken part in earlier trials of avalglucosidase alfa (Nexviadyme). It aims to check the drug's long-term safety and effectiveness by giving it every two weeks as an IV infusion. The study will continue until the dru…

This study offers continued access to an oral medication called levosimendan for people with pulmonary hypertension (high blood pressure in the lungs) and a type of heart failure where the heart pumps normally but is stiff. About 800 participants who completed a previous levosime…

This study tests a new monthly injection called ziltivekimab in 10,000 people who recently had a heart attack. The goal is to see if it can lower the risk of having another heart attack, a stroke, or dying from heart disease. Participants will receive either the study drug or a p…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This study tests a new device that uses shock waves to break up calcium deposits in heart arteries before placing a stent. About 335 adults with coronary artery disease will receive this treatment at up to 55 US sites. The goal is to see if the device helps stents work better and…

This real-world study is following 7,000 Chinese adults with established heart disease to see if adding Repatha® (a cholesterol-lowering injection) to their usual care reduces major cardiovascular events like heart attacks, strokes, and heart-related death. Participants are eithe…

This trial tests whether an AI system that flags at-risk Medicare Advantage members and suggests care actions, reviewed by a nurse, can reduce overall healthcare spending over a year. About 9,900 participants in Utah are assigned to either this AI-supported navigation or usual ca…

This study tests whether adding ablation of scarred heart tissue to standard pulmonary vein isolation helps people with persistent atrial fibrillation stay free of irregular heartbeats. Two hundred participants will be randomly assigned to one of two ablation procedures. The main…

This trial tests whether taking a daily low dose of colchicine, an anti-inflammatory drug, can reduce the risk of heart attacks, strokes, and other heart problems in Chinese patients who have had a stent placed for coronary heart disease. Researchers will compare two different do…

This first-in-human trial tests a small device called the FIRE1 System, which is implanted in a major vein to monitor fluid buildup in people with heart failure. The study enrolls up to 50 adults who have recently needed hospital care for heart failure. Researchers check whether …

This study tests whether the drug nicorandil can lower the risk of serious heart problems like heart attacks and strokes in people with coronary artery disease who are on kidney dialysis. Researchers are giving 15 mg of nicorandil daily to 268 participants and tracking heart-rela…

Researchers are testing whether a defined plant-based diet can improve blood vessel function in people with coronary artery disease. Participants will follow the diet while researchers measure changes in blood vessel health and heart rhythm over time. The goal is to see if this d…

This study tests whether a personalized 12-week cardiac rehabilitation program, offered in a safety net clinic, helps more heart patients attend rehab compared to the usual referral to an outside program. Researchers will enroll 100 adults who have had a heart attack, surgery, or…

This early-stage study tests a gene therapy called AT845 for adults with late-onset Pompe disease, a condition that weakens muscles. The treatment aims to deliver a working copy of the GAA gene to muscle cells. Eleven participants who have been on standard enzyme replacement ther…

This early study tests a new device called the NORM™ system in 25 adults with heart failure. The device is placed inside a large vein near the heart to send health information to doctors. The goal is to see if the implant is safe and can reliably transmit data, which may help man…

This study tests doing two heart procedures at the same time for people with atrial fibrillation. First, doctors use pulsed field energy to fix the heart's rhythm. Then, they implant a small device to close off a part of the heart where clots can form. The goal is to see if this …

This study compares two ways of delivering cardiac rehabilitation: in-person sessions and telehealth sessions. Cardiac rehab includes exercise training, health education, and counseling for people with heart conditions like heart attack, heart failure, or after heart surgery. The…

This study tests a new device that uses heat to destroy tiny areas in the heart causing short bursts of irregular heartbeat (paroxysmal atrial fibrillation). About 300 adults with this condition will receive the procedure and be monitored for a year. The goal is to see if the tre…

This phase 2 trial is testing the drug ruxolitinib in people with hypereosinophilic syndrome, a rare condition where the body produces too many eosinophils (a type of white blood cell), causing organ damage. The study aims to see if ruxolitinib can normalize blood cell counts and…

This trial tests whether L-carnitine, a natural compound, can reduce the damage that occurs when blood flow is restored to the heart after a heart attack. Researchers will give L-carnitine to patients with ST-elevation myocardial infarction (STEMI) who undergo angioplasty, and me…

This study tests whether a program using community health workers and medication can lower blood pressure and prevent heart failure in 364 adults from Detroit and Cleveland. Participants with high blood pressure or risk factors will receive personalized support and medication. Th…

This study tests a new device (Laminar) to close the left atrial appendage, a small pouch in the heart, in 1500 people with non-valvular atrial fibrillation. The goal is to see if it is safer and works better than existing devices to reduce the risk of stroke and blood clots. Par…

This study is testing a new device that uses pulsed electric fields to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. The procedure aims to isolate the pulmonary veins to restore normal rhythm. Researchers will enroll 440 people who have not …

This study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …

This trial tests a device called the TricValve system in people with severe tricuspid regurgitation, a condition where the heart's tricuspid valve leaks blood backward. The device is implanted through a catheter into the veins leading to the heart, aiming to reduce symptoms witho…

This trial compares two strategies for placing stents in people with coronary artery disease, where arteries that feed the heart become narrowed. One strategy uses a blood-flow measurement called fractional flow reserve to decide whether a stent is needed. The other uses intravas…

This trial compares two different TAVI devices (Evolut FX and Sapien 3 Ultra Resilia) used to replace a narrowed heart valve in people with aortic stenosis. About 1,346 patients will be randomly assigned to get one device or the other. Researchers will track deaths, strokes, valv…

This study tests whether high-intensity interval training (HIIT) can improve cardiovascular health in adults who had surgery to repair coarctation of the aorta, a narrowing of the main artery. Participants are randomly assigned to do HIIT at home, HIIT in a supervised clinic, or …

This trial tests whether a supervised 12-week high-intensity interval training (HIIT) program can safely improve cardiorespiratory fitness in adults who have previously had spontaneous coronary artery dissection (SCAD), a cause of heart attack that often affects younger women. Pa…

This trial tests a new model where patients with infections receive intravenous antibiotics at home instead of staying in the hospital. Nurses from a municipal response team visit the patient, while hospital doctors oversee the treatment remotely using telemedicine and welfare te…

This trial tests whether a dietary supplement called Endocalyx Pro can reduce excess sodium and water in people with chronic heart failure. Participants will take either the supplement or a placebo daily for 8 weeks, with follow-up for 12 weeks. The study measures changes in a bl…

This early trial is testing a small, implantable sensor that measures pressure inside the heart for people with heart failure who are getting a mechanical heart pump (LVAD). The goal is to see if the sensor can be safely and accurately placed and whether it can provide reliable p…

This trial tests whether cryoablation, a procedure that freezes heart tissue to block faulty electrical signals, can control early persistent atrial fibrillation (AF) when used as the first treatment. Participants have symptomatic AF that has lasted between 7 days and 3 years and…

This trial is testing a new device called the HARPOON system, which is designed to repair a leaky mitral valve in the heart while it is still beating, avoiding the need for open-heart surgery. The study will include people with severe degenerative mitral regurgitation, a conditio…

This study compares two procedures for severe aortic valve stenosis: transcatheter aortic valve implantation (TAVI), a less invasive approach, and standard open-heart surgery. It will follow 4,000 high-risk patients for up to 24 months to see which method leads to fewer deaths, h…

This study tests a new device called enVast that removes blood clots from heart arteries during a severe heart attack (STEMI). About 148 adults with large clots will either get standard care or standard care plus the enVast device. The goal is to see if the device reduces the siz…

This study is testing a device called PASCAL, which is used to repair a leaky mitral valve in the heart without open-heart surgery. The procedure involves guiding a small clip through a blood vessel to the heart to help the valve close properly. Researchers are following about 1,…

This study compares two approaches for replacing an infected aortic valve: using a cryopreserved aortic homograft (a preserved human donor valve) versus conventional mechanical or tissue prosthetic valves. The goal is to see which method leads to fewer complications, such as deat…

This pilot trial is testing whether a device called the Coronary Sinus Reducer can help people with angina (chest pain) who have no significant blockages in their coronary arteries. The device, shaped like an hourglass, is placed into a vein in the heart to improve blood flow. Th…

This trial investigates the best way to treat people who have a heart attack and also have other narrowed arteries. It compares doing an immediate procedure to open those other arteries, guided by a pressure wire, versus waiting and using a heart scan to decide later. The goal is…

This study tests whether giving extra fluids (saline) through an IV during and after a heart procedure called pulsed field ablation can prevent acute kidney injury. The procedure is used to treat atrial fibrillation, a common heart rhythm problem, but can sometimes harm the kidne…

This trial tests whether taking a 15-minute hot bath after each exercise session improves recovery in people who recently had a heart attack. Half of the 30 participants will do standard exercise rehab plus hot water immersion, while the other half does exercise alone. The study …

This trial asks whether giving only ticagrelor (a blood thinner) after a heart attack, instead of the usual ticagrelor plus aspirin, is just as safe and might reduce bleeding and heart muscle damage. About 200 people who had a type of heart attack called STEMI and underwent a ste…

This trial is testing whether a supervised exercise program can reduce the risk of death, another heart attack, or stroke in people who have already had a heart attack. About 9,700 participants will be randomly assigned to either a four-year program with a personal trainer or to …

This study tests a new approach called 'pill-in-pocket' anticoagulation for people with atrial fibrillation (AF), a heart rhythm condition that raises stroke risk. Instead of taking blood thinners every day, participants would stop them after a 30-day AF-free period and only rest…

This trial compares standard versus extra pulsed field ablation applications during pulmonary vein isolation in people with atrial fibrillation. The goal is to see if more targeted ablations improve freedom from irregular heart rhythms for up to 18 months. Participants are adults…

This trial tests whether a digital tool that prompts doctors to adjust heart failure medications can improve care. The tool uses home monitoring and patient data to suggest medication changes. The study includes over 1,300 adults with heart failure and will measure hospitalizatio…

This study tests a new device that uses extreme cold (cryoablation) to treat a fast, dangerous heart rhythm called sustained monomorphic ventricular tachycardia. About 206 adults with this condition will receive the freezing treatment. The goal is to see if it safely stops the ab…

This study looks at whether opening a completely blocked heart artery with a procedure called PCI, on top of taking standard heart medications, helps people live longer and feel better compared to medications alone. About 2000 adults with stable heart disease and symptoms like ch…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This trial is testing a new type of heart valve made from a material that the body absorbs over time. It is designed for children and young adults who need surgery to fix a congenital heart defect affecting the passage from the heart to the lungs. The valve is implanted during su…

This study asks whether wearing a small heart monitor for two weeks at a time, twice, can better detect hidden irregular heartbeats (atrial fibrillation) in older adults who recently had a stroke or mini-stroke, compared to the usual 1-2 day monitoring. Atrial fibrillation is a m…

This trial tests whether a personalized exercise prescription, based on a graded exercise test and target heart rate, improves fitness more than standard perceived exertion-based exercise in older adults (60+) recovering from heart events like heart attacks or heart surgery. Part…

This study tests a new method to preserve hearts from donors after circulatory death. The hearts are kept cool and oxygenated using a special machine during transport. The goal is to see if this helps more people get heart transplants and survive. The study involves 20 adults alr…

This study compares a newer pacemaker method, left bundle branch area pacing (LBBAP), to the standard right ventricular pacing in 200 patients with heart block and normal heart function. The goal is to see if LBBAP better preserves the heart's pumping ability and reduces complica…

This trial tests two methods of harvesting the left internal mammary artery for heart bypass surgery. One method strips the artery clean of surrounding tissue; the other leaves the tissue intact. Researchers want to know which approach keeps the graft open longer and reduces the …

This trial tests whether an 8-week course of the immunosuppressive drug prednisone can reduce episodes of ventricular tachycardia (a potentially fatal fast heart rhythm) and improve heart function in people with non-ischemic cardiomyopathy and confirmed heart inflammation. Partic…

This study tests whether adding extra ablation to the back wall of the heart's left atrium improves outcomes for people with persistent atrial fibrillation (a type of irregular heartbeat). About 206 participants will receive either standard vein isolation or vein isolation plus b…

This trial compares two types of transcatheter heart valves—one designed to sit above the natural valve opening (supra-annular) and one that sits within it (annular)—in people with severe aortic stenosis and a small aortic annulus (≤23 mm). The goal is to see which valve leads to…

This study tested a small sensor placed in the lung artery to help doctors monitor heart failure patients remotely. 738 people with advanced (NYHA Class III) heart failure took part. The goal was to see if using the sensor could reduce hospitalizations and deaths compared to a ta…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can treat left-sided endocarditis as safely as the standard 4-6 week regimen. Adults with endocarditis caused by specific bacteria (Streptococci, Enterococcus faecalis, or Staphy…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can safely treat bacterial endocarditis. Standard treatment lasts 4-6 weeks, but this study tests a personalized approach based on factors like fever and blood tests. The goal is…

This trial tests whether a personalized training program called 'Kleuter Extra' can improve executive functioning—skills like attention, self-control, and planning—in preschoolers aged 4 to 6 who have severe congenital heart disease. Many children with this condition face thinkin…

This pilot study tests whether a new pacing method called LOT-CRT, which paces two areas of the heart at once, works better than standard pacing alone in people with heart failure. Ten patients will each receive a special pacemaker and try both pacing settings for 6 months each. …

This study tests a prototype smartphone app called Appet HEART, designed to support personalized care for people with coronary artery disease after they leave the hospital. Researchers want to see how often patients use the app, who benefits most, and whether it improves recovery…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to high-intensity statin therapy can prevent future cardiovascular events in people who have recently had a heart attack or unstable angina and underwent a stent procedure. About 1,200 partic…

This trial tests a procedure called pulmonary arterial denervation (PADN) for people with heart failure who also have high blood pressure in the lungs. A special catheter delivers radiofrequency energy to nerves in the pulmonary artery, which may help lower pressure and improve h…

This study tests a wrist-worn device called CardiaCare RR2 that stimulates the median nerve to calm irregular heart rhythms after catheter ablation for atrial fibrillation (AF). About 34 adults who have had AF ablation will use the device daily for six months. Half will receive a…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This study investigates whether diagnosing and treating obstructive sleep apnea with CPAP therapy early, while patients are still in the hospital for heart problems, can reduce the chance of being readmitted within 30 days. The trial enrolls adults with heart failure, heart attac…

This trial tests a new device called the Edwards SAPIEN M3 System for people with severe mitral regurgitation, a condition where a heart valve leaks blood backward. The device is placed using a thin tube threaded through blood vessels, avoiding open-heart surgery. The study inclu…

This trial tests whether placing a balloon in the aorta (REBOA) during CPR can improve blood flow to the heart and brain in people who have a cardiac arrest outside the hospital. The study includes 200 adults with non-traumatic cardiac arrest who receive CPR within 10 minutes. Re…

This trial tests whether adding posterior wall isolation to standard pulmonary vein isolation reduces atrial fibrillation recurrence in people with persistent AF. About 482 adults aged 20 to 80 will be randomly assigned to one of the two procedures using pulsed-field energy. Part…

This study evaluates a special balloon coated with sirolimus, a drug that helps prevent arteries from narrowing again after angioplasty. The balloon is used during routine procedures to open blocked heart arteries in people with coronary artery disease. Researchers are tracking h…

This trial tests a device called the Edwards PASCAL system, which is used to repair a leaky tricuspid valve in the heart without open-heart surgery. The study includes 300 people with severe tricuspid regurgitation who are candidates for this procedure. Researchers are checking h…

This trial tests whether using a special camera inside the arteries (optical coherence tomography, or OCT) is better than standard pressure-wire measurements for deciding which non-blocked arteries need stenting in people who have just had a heart attack. About 1,425 participants…

This study tests a new treatment called NXC-201 CAR-T for people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The therapy uses a patient's own immune cells, modified to target and destroy the cells producing these proteins. The trial is open to …

This phase 2b trial tests whether adding ALXN2220 to eplontersen works better than eplontersen alone for adults with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart. About 326 participants will receive either the combinati…

This study follows about 3000 people with complex coronary artery disease who receive the Ultimaster Nagomi stent, a device that slowly releases a drug to keep arteries open. The goal is to see how often the stent fails—meaning heart-related death, heart attack, or need for anoth…

This study tests whether a fully online exercise program is practical and acceptable for people with heart failure. Participants are randomly assigned to either a supervised online exercise group or a self-managed home exercise program for 8 weeks. The goal is to see if people st…

This study looks at whether giving an extra balloon inflation after placing a new heart valve (TAVI) helps the valve open more evenly and work better. About 146 people with severe aortic stenosis will be randomly assigned to receive this extra step or not. The goal is to see if i…

This phase 2 trial tests an oral drug called venglustat, given alongside the standard enzyme therapy Cerezyme, in adults with Gaucher disease type 3 (a rare genetic disorder affecting the body and brain). The study has four parts: first, it checks spinal fluid biomarkers to disti…

This trial investigates whether intravenous infusions of tiny particles (extracellular vesicles) from heart progenitor cells can safely improve heart function in people with severe dilated cardiomyopathy and heart failure. Participants receive three infusions and are monitored fo…

This study tests a transitional care model for older adults (65+) hospitalized with heart failure, COPD, or pneumonia. The model provides extra education, social services, and coordination among doctors after discharge. Researchers compare this to usual care to see if it reduces …

This study tests whether strengthening the muscles used for breathing can improve exercise capacity, heart function, and quality of life in people with chronic heart failure. Participants with reduced or mildly reduced heart pumping ability will be randomly assigned to one of two…

This study tests whether a mechanical heart pump called the HeartMate III (an LVAD) helps people with end-stage heart failure live longer and with fewer strokes compared to taking standard heart failure medications. About 80 adults with severe heart failure are randomly assigned …

This study investigates whether empagliflozin, a drug typically used for diabetes, can help people with worsening heart failure get rid of extra fluid. Researchers will give 60 participants either empagliflozin or a placebo for six weeks, alongside their usual diuretic medication…

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This study looks at whether giving people a heart-lung machine (ECPR) right where they collapse from a cardiac arrest can help more of them survive to leave the hospital. Researchers will compare people who get this extra treatment with those who get standard CPR and care. The st…

This study tests whether combining two procedures—closing the left atrial appendage and using pulsed field ablation to correct heart rhythm—works better than closing the appendage alone in people with persistent atrial fibrillation and high stroke risk. Fifty participants will be…

This trial tests whether a home-based tele-rehabilitation program is as effective as traditional center-based cardiac rehabilitation for people who have recently had a heart attack (acute coronary syndrome). Participants will either complete 20 sessions at a rehab center or 20 se…

This study tests whether a supplement called sulforaphane, found in broccoli sprouts, can help prevent age-related declines in heart function. Researchers will give the supplement or a placebo to adults over 60 with a type of heart failure called HFpEF. They will measure heart fu…

This early study tests a new device called the DurAVR™ heart valve in 15 people aged 65 and older with severe aortic stenosis, a condition where the heart's aortic valve becomes narrowed. The valve is implanted through a catheter (TAVR) without open-heart surgery. The main goals …

This study tests a 12-week home-based digital program called eCardiacRehab for people who have had a heart procedure (PCI). The program includes video messages, modules, and tracking to support recovery. Researchers want to see if patients will use it regularly and find it accept…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study tests a new way to help people with heart failure in Uganda manage their condition. It combines a standard care program with a mobile app that tracks symptoms and gives advice. The goal is to see if this approach improves self-care and reduces deaths or hospital stays.…

This study tests whether switching to avalglucosidase alfa is safe and more effective for people with late-onset Pompe disease whose condition has worsened on the standard treatment, alglucosidase alfa. Participants receive biweekly infusions of the new drug and are monitored for…

This study tests whether a personalized catheter ablation approach, guided by mapping low-voltage areas in the heart, works better than standard ablation for people with persistent atrial fibrillation (AFib). About 510 adults with persistent AFib will be randomly assigned to rece…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests whether a high-intensity statin and a low-dose anti-inflammatory drug (colchicine) can slow the buildup of artery plaque in people with a high genetic risk for heart disease. Researchers will use CT scans to measure changes in plaque over one year. The trial invo…

This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, hear…

This study tests a device called the Edwards APTURE shunt, which is implanted in the heart to create a small opening that lowers pressure. The goal is to see if it can improve symptoms and quality of life for 100 people with a certain type of heart failure. Half of the participan…

This early-phase trial tests whether giving stem cells (from a donor) during heart-lung bypass surgery is safe for infants under 6 months with certain congenital heart defects. Seventeen infants will receive the cells while undergoing heart repair. The main goal is to check for s…

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose feve…

This study tests a smartphone app called Medly that helps heart failure patients monitor their health after a hospital stay. The app reminds patients to check their weight and symptoms, and sends the information to their care team. The goal is to see if using the app improves pat…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study is testing a device called the Tendyne mitral valve system in 200 people with mitral regurgitation, a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The valve is implanted through a tube in an artery, avoiding open-hear…

This study tests a new device that combines two heart therapies: one to strengthen heartbeats and another to stop dangerous rhythms. About 300 adults with heart failure and a weak heart pump will get the device. Researchers will check if it safely converts life-threatening heart …

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This study looks at whether doing a heart procedure called cryoablation right away in the emergency room can help people with recent atrial fibrillation (AFib). About 350 adults with AFib that started within the past year will be randomly assigned to get either immediate ablation…

This study tests whether a wearable sensor that measures lung fluid can help doctors better treat fluid buildup in patients hospitalized for acute heart failure. About 216 adults will be randomly assigned to either standard care or care guided by the sensor. The goal is to see if…

This study compares a less invasive procedure (TEER) to standard open-heart surgery for people with severe mitral regurgitation, a condition where a heart valve doesn't close properly. About 600 adults will be randomly assigned to one of the two treatments. The main goal is to se…

This study looks at whether measuring blood pressure inside the heart's left upper chamber during a procedure for atrial fibrillation (an irregular heartbeat) can spot patients with hidden heart failure. If the pressure is high, patients get a heart failure checkup and medication…

This study is tracking 511 patients with severe tricuspid regurgitation who are treated with the Abbott TriClip device in real-world settings. The main goal is to see if the device can successfully reduce the valve leak by at least one grade at discharge. Researchers are also mon…

This study tests whether using a special imaging tool called OCT during stent placement leads to fewer heart problems over two years compared to standard methods. About 1,200 adults with blocked heart arteries that need complex stenting are taking part. The goal is to see if OCT …

This study tests a new device that uses special electrical pulses to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. About 150 adults aged 18-75 who have not responded well to medication will receive the treatment. The goal is to see if the de…

This study looks at whether doing a preventive heart ablation (a procedure to destroy small areas of heart tissue causing irregular rhythms) before LVAD surgery can reduce serious problems like dangerous heart rhythms, death, blood clots, or heart failure in the first 30 days aft…

This study tests if a newer pacing method called left bundle branch pacing (LBBP) is better than standard right ventricular pacing (RVP) at preserving heart function in 683 adults with atrioventricular block (a type of heart block). Participants will be randomly assigned to one o…

This study tests whether a special heart pacing technique (left bundle branch pacing) combined with standard heart failure drugs can improve heart function better than drugs alone. It includes 50 adults with non-ischemic heart failure and a specific heart block. The main goal is …

This study compares two ways to replace a narrowed heart valve in people with severe aortic stenosis who are at intermediate risk for surgery. About 1,400 participants will be randomly assigned to get either a less invasive TAVI procedure or open-heart surgery (SAVR). The main go…

This phase 3 trial tests two things at once in 2312 people with coronary artery disease: a new drug-coated stent (Angiolite) versus a standard stent, and a shorter course of blood thinners versus the usual longer course. The goal is to see if the new stent works as well and if sh…

This study is tracking 500 heart failure patients in Germany who receive a small device called the InterAtrial Shunt. The device is implanted to create a tiny passage between the heart's upper chambers, which may help lower pressure and improve breathing and quality of life. Rese…

This study tests whether briefly inflating a blood-pressure cuff on the arm before non-cardiac surgery can reduce heart damage in high-risk patients. Over 1,200 participants will receive either the cuff procedure or no intervention. The goal is to see if this simple, low-cost tec…

This study tests a technique called acute normovolemic hemodilution (ANH) in 2000 high-risk heart surgery patients. Before the heart-lung machine is used, doctors remove some blood and replace it with fluids. The goal is to see if this reduces the number of patients who need a bl…

This study looks at 3,500 people with severe tricuspid regurgitation, a common heart valve problem in older adults. It compares medical therapy (diuretics), surgery, and a less invasive transcatheter procedure to see which works best and when to treat. The goal is to improve surv…

This study compares three catheter ablation techniques for people with persistent atrial fibrillation (AF), a heart rhythm disorder. About 617 adults having their first ablation will be randomly assigned to one of three groups: isolating the pulmonary veins alone, adding ablation…

This study is testing a custom-made artificial heart valve, called TRICENTO, in 15 people with carcinoid heart disease who have severe leakage of the tricuspid valve and cannot have surgery. The valve is delivered through a catheter, avoiding open-heart surgery. The goal is to se…

This pilot study tests whether using advanced imaging (ECGI, MRI, and PET scans) to identify abnormal heart tissue and electrical circuits can improve catheter ablation for persistent atrial fibrillation. Fifty-two adults with persistent AF who have not had prior ablation will re…

This study tests whether showing people their own coronary CT scans can motivate them to lower their LDL cholesterol and reduce side effects from statins. 273 adults with non-obstructive coronary artery disease will be followed for 12 months. The goal is to see if visual feedback…

This study tests a minimally invasive heart bypass surgery for people with blockages in multiple coronary arteries. Instead of opening the chest fully, surgeons work through a small incision on the left side. The goal is to see if this approach is safe and effective, with fewer c…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study compares two catheter ablation techniques for atrial fibrillation (AF), a condition where the heart beats irregularly. One method uses a standard approach with a drug called adenosine to find missed spots, while the other adds an extra ring of ablation without the drug…

This study compares two ways to decide which blocked arteries to stent in heart attack patients who have multiple blockages. One method uses standard X-ray images; the other uses a computer analysis of those images to measure blood flow. About 1,800 patients will be randomly assi…

This study looks at two treatment options for people who have both a leaky heart valve (ischemic mitral regurgitation) and blocked heart arteries. One option is open-heart surgery to fix the valve and bypass the blockages at the same time. The other is a less invasive procedure t…

This study compares a new leadless pacemaker (Micra AV) to a standard dual-chamber pacemaker in 100 patients aged 70 and older with heart block. The goal is to see if the leadless version works just as well for exercise capacity. Participants are randomly assigned to receive one …

This study tests whether a newer pacing method (conduction system pacing) is as good as or better than standard biventricular pacing in heart failure patients with atrial fibrillation who need a heart ablation. About 82 participants will be randomly assigned to one of the two pac…

This study tests whether a new leadless pacemaker (Micra AV) is better than a traditional wired pacemaker for people aged 75 and older with heart block. The goal is to see if the leadless device improves quality of life, patient acceptance, and exercise ability. Eighty participan…

This study compares two ways of programming implantable defibrillators (ICDs) in 398 Japanese patients. One group uses early, multiple bursts of rapid pacing (ATP) to stop dangerous heart rhythms, while the other uses a longer detection time before pacing. The goal is to see whic…

This study looks at two ways to treat a type of irregular heartbeat called non-paroxysmal atrial fibrillation (AFib) that doesn't go away on its own. Both methods use a new technique called pulsed-field ablation to destroy tiny areas of heart tissue causing the problem. One group…

This study aimed to compare a new type of heart stent that slowly dissolves over time (MeRes100) with standard permanent metal stents in people with coronary artery disease. The trial was planned to include about 2,000 participants worldwide, but it was withdrawn before enrolling…

This study planned to test whether cooling the body before and after opening a blocked artery could help people having a heart attack. It was designed to include 80 patients at up to 15 hospitals. However, the trial was withdrawn before anyone was enrolled, so we have no informat…

This phase 2 trial tests whether empagliflozin (Jardiance), a diabetes drug, can reduce the 'no-reflow' phenomenon—when blood flow fails to fully restore after angioplasty—in 162 heart attack patients. Participants receive a loading dose before the procedure and daily doses for 3…

This study tests whether a tailored exercise and education program, given before and after a first-time atrial fibrillation ablation, can improve heart fitness and quality of life compared to standard care. About 107 adults scheduled for ablation will be randomly assigned to eith…

This study tests a new, less invasive surgical approach for people with persistent atrial fibrillation (AFib), a heart rhythm problem that can be hard to treat. The procedure combines two techniques: ablation (creating tiny scars to block faulty signals) and closing off the left …

This study tests a new heart valve called the NAVITOR, placed using a thin tube (catheter) without open-heart surgery. It includes 434 people with severe aortic stenosis who are at intermediate or low risk for surgery. The main goals are to check for leaks around the valve at 30 …

This study tests a daily pill (obicetrapib plus ezetimibe) to see if it can reduce fatty plaque buildup in the arteries of 300 adults with heart disease. Participants must already be on cholesterol-lowering therapy but still have high LDL cholesterol and measurable plaque. The tr…

This early study is testing a new balloon-expandable heart valve device (TAVI) in 8 people with severe aortic stenosis who are at increased surgical risk. The goal is to see if the device can be safely delivered and perform as intended. Because this is a first-in-human study with…

This study tests whether adding an external support device to vein grafts during heart bypass surgery helps keep them open over time. Researchers will compare patients who receive the support with those who don't, tracking graft function and symptoms like chest pain. The goal is …

This study tests a new device that repairs leaky mitral heart valves without stopping the heart or using a heart-lung machine, compared to standard open surgery. About 585 people with moderate to severe mitral regurgitation will take part. The goal is to see if the device is safe…

This study compares using a manual clot-removal catheter (Export) before standard balloon angioplasty versus angioplasty alone in 300 heart attack patients with completely blocked arteries. The goal is to see if removing the clot first improves blood flow and reduces in-hospital …

This study tests a new enzyme replacement therapy called avalglucosidase alfa in babies with infantile-onset Pompe disease, a rare genetic disorder that causes severe muscle weakness and breathing problems. The treatment is given through an IV every other week for up to 4 years. …

This study tests a catheter ablation procedure for people with persistent or long-standing persistent atrial fibrillation, a type of irregular heartbeat that is hard to treat. The procedure uses electroporation and radiofrequency energy to create scars in the heart that block abn…

This phase 2 trial is testing whether a patient's own bone marrow stem cells can improve heart function and ease symptoms in people with dilated cardiomyopathy and heart failure. Twenty participants will have stem cells collected from their hip and then infused into their heart a…

This study looks at two ways to treat heart attacks in people aged 75 and older who have several blocked heart arteries. One approach only fixes the artery that caused the heart attack, while the other uses a special test to decide which other blockages to open. The goal is to se…

This study tests whether a computer alert in doctors' charts can help more atrial fibrillation patients get blood thinners to prevent strokes. About 5,094 patients and their doctors are involved. The alert fires during visits if a patient has high stroke risk but isn't on blood t…

This study compares a special pacemaker procedure called left bundle branch pacing (LBBP) plus standard heart failure drugs against drugs alone in 36 people with mild heart failure. The goal is to see if early pacing improves the heart's pumping ability more than medication. Part…

This early study tests a new catheter that uses two types of energy (radiofrequency and pulsed field) to treat rapid heartbeats from the lower chambers. Ten adults with drug-resistant ventricular arrhythmias will receive the procedure. The main goal is to check safety and see if …

This study compares a new heart pump (EVAHEART®2) to a current pump in 399 adults with severe heart failure. The goal is to see if the new pump helps people survive until a heart transplant or recover enough to have the pump removed, without suffering a disabling stroke or severe…

This early study tests a new freezing treatment for people who recently had a heart attack or unstable chest pain. The treatment uses a special balloon to freeze high-risk plaque in the heart's arteries that could rupture and cause another heart attack. The goal is to stabilize t…

This study follows 255 Chinese patients who received the INSPIRIS RESILIA aortic valve to see how safe and well it works over several years. Researchers track problems like valve failure, blood clots, bleeding, and the need for another surgery. The goal is to confirm the valve's …

This study tests whether measuring amiodarone levels in the blood helps doctors choose the right dose for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). About 80 adults will receive different daily doses (100, 200, or 400 mg) and be monitored for thre…

This study is testing whether daily shakes made from bilberries and oats can lower LDL cholesterol and improve exercise capacity in people who have had a heart attack or have type 2 diabetes. 900 participants will drink either a bilberry shake, an oat shake, a combination shake, …

This study tests whether an implantable heart monitor with remote follow-up can help doctors decide when to prescribe blood thinners to patients who have had a heart attack and developed new atrial fibrillation. The goal is to reduce bleeding complications compared to the standar…

This study tests two different ablation techniques using a new, safer method called pulsed-field ablation (PFA) in 300 adults with persistent atrial fibrillation (a type of irregular heartbeat). One group gets standard vein isolation, while the other gets additional targeted burn…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This early study tests a device that keeps donor hearts alive outside the body for longer periods before transplant. The goal is to see if hearts preserved this way work well within 15 days after surgery. Twenty adults with severe heart failure who cannot get a standard transplan…

This trial tests whether a procedure called catheter ablation works better than anti-arrhythmic drugs for people with structural heart disease who have had a dangerous fast heart rhythm (ventricular tachycardia). About 162 participants will be randomly assigned to either ablation…

This study looks at whether people with stable ischemic heart disease (but with normal heart pumping function and no ongoing chest pain or arrhythmias) can safely stop taking beta-blockers. About 59 participants will either continue or stop their beta-blocker and be followed for …

This study compares a new software tool called FFRangio, which uses 3D X-ray images to assess heart artery blockages, against the standard invasive pressure wire method. About 1,924 adults with coronary artery disease are participating. The goal is to see if the software-guided t…

This study tests whether a comprehensive program of lifestyle changes (diet, exercise, education) plus aggressive cholesterol-lowering drugs, guided by PET heart scans, can reduce heart attacks and deaths better than standard medical care. Over 1,000 adults with suspected or know…

This study looks at whether starting empagliflozin early in patients with cardiogenic shock (a severe heart pump failure) can reduce deaths and hospital readmissions within 3 months. Researchers compared 418 patients who received the drug plus usual care against those who got usu…

This study tests if using a temporary heart pump (Impella CP) for 30 minutes before opening a blocked artery can reduce heart muscle damage in people having a severe heart attack. About 527 adults with a first-time anterior heart attack are enrolled. The goal is to see if this ap…

This study compares two treatments for people aged 80 and older who have a completely blocked heart artery: a procedure to open the blockage with a stent (PCI) versus taking medications alone. Researchers want to see which approach leads to fewer major heart problems and a better…

This study tests a single dose of SRP-9003 gene therapy in 17 people with limb girdle muscular dystrophy 2E/R4, a genetic muscle-weakening disease. The goal is to restore a missing protein in muscle cells and improve muscle function. Both walkers and non-walkers can join, and the…

This study tests a new care model for people who have had a heart attack. It uses digital tools and specially trained pharmacists to help manage health after leaving the hospital. The goal is to reduce the risk of another heart attack or death. The study involves 1,633 adults in …

Researchers are studying whether artificial intelligence can extract useful warning signs from coronary CT angiography (CCTA) scans in people with coronary artery disease. The study reviews existing medical records from 3,000 patients across five hospitals who had both a CCTA and…

Researchers compare two types of CT scanners for imaging heart arteries in people with suspected chronic coronary syndrome. One scanner uses standard energy-integrating detectors, while the other uses newer photon-counting detectors that may produce clearer pictures with fewer fa…

Researchers test whether an AI algorithm called AK-AVS can spot moderate-to-severe aortic stenosis, a narrowing of the heart's aortic valve, in older adults who have not been diagnosed. The study reviews about 4,000 routine electrocardiograms (ECGs) already collected during prima…

During cardiac arrest, rescuers check for a pulse by hand, but studies show this method is often wrong. This trial tests whether a carotid ultrasound in pulsed-wave Doppler mode can detect a pulse more accurately and quickly. Researchers will compare ultrasound findings with manu…

Researchers are testing whether an implanted loop recorder can detect atrial fibrillation in people who have had a stroke. The device continuously monitors heart rhythm for up to a year or longer. The pilot trial enrolls 24 patients across three centers to see if a larger study o…

This study compares two blood test schedules for diagnosing heart attacks in the emergency room: the standard 3-hour test and a newer 1-hour test. Over 64,000 adults with chest pain will be enrolled to see if the faster test is just as safe and accurate. If it works, patients cou…

Researchers are testing whether an artificial intelligence system can analyze echocardiogram images and draft reports as accurately as experienced sonographers in patients with heart failure. The trial enrolls adults with new or worsening heart failure symptoms and elevated heart…

Researchers are studying whether high levels of a blood protein called Galectin-3 can predict which patients will develop an irregular heartbeat after coronary artery bypass grafting. About 90 adults scheduled for this surgery will give a blood sample before the operation and be …

Researchers at Beijing Anzhen Hospital are studying whether a computer model that combines two types of heart scans can predict 12-month survival in people with light-chain cardiac amyloidosis, a condition where abnormal proteins stiffen the heart. The study enrolls 49 patients w…

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

This study looks at two new methods to tell apart blockages in large versus tiny heart arteries. About 68 adults with known or suspected coronary artery disease will get a PET scan and a heart catheterization. Researchers will compare the new measurements with standard tests to s…

This trial tests whether actively screening adults with obesity for early signs of heart failure can improve their health outcomes. Adults aged 45 and older with a BMI of 30 or higher, who have no known heart disease, will be randomly assigned to receive either standard care or a…

This study asks whether tiny RNA molecules in the blood can signal a higher risk of dangerous heart rhythms in people who have heart failure after a heart attack and use an implanted defibrillator. Researchers collect blood samples from 57 participants and compare RNA patterns be…

This trial tests whether a point-of-care blood test for NT-proBNP, which gives results at the bedside in about 12 minutes, can help doctors diagnose new heart failure faster in hospital patients with unexplained breathlessness. Researchers will compare time to diagnosis, time to …

This trial tests whether a smartwatch can accurately detect atrial fibrillation (AF) in people at high risk, such as those who've had a stroke or have symptoms. Participants will wear the CS Medical Watch while also having an implantable loop recorder (ILR) in place, and the watc…

This trial is testing whether a new PET imaging tracer, 18F-flurpiridaz, can detect coronary artery disease as accurately as the current standard, 82Rb-chloride. The study will involve 60 adults scheduled for a clinically indicated PET scan. Researchers will compare the diagnosti…

This trial tests whether a coronary CT angiography (CCTA) scan can safely identify heart attack patients who do not need invasive angiography. About 300 patients with non-ST-elevation myocardial infarction (NSTEMI) will undergo CCTA before the standard invasive test. The goal is …

This trial is developing an artificial intelligence system that reads electrocardiograms (ECGs) to detect congenital heart disease in children. Researchers are collecting ECG data from thousands of children, including those with common and rare heart defects, to train a deep-lear…

This study is testing whether artificial intelligence can detect transthyretin amyloid cardiomyopathy (ATTR-CM), a serious and often underdiagnosed heart condition, earlier than usual. Researchers will use AI algorithms to analyze routine ECGs and heart ultrasounds from up to 1.5…

This study tests whether a compact 3-lead ECG device can accurately detect acute coronary syndrome (heart attack) in adults arriving at the emergency department with chest pain. Participants receive a HeartBeam ECG recording within 10 minutes of the standard 12-lead ECG. The goal…

This study tests whether combining an AI-enhanced electrocardiogram (ECG) with a focused heart ultrasound can better detect structural heart disease in people without symptoms. About 2,705 adults with no known heart problems will get an AI-ECG, and if it flags a concern, they'll …

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study is testing whether a special home blood pressure monitor that can detect atrial fibrillation (AFib) helps diagnose the condition faster in older adults with high blood pressure. About 1,900 participants aged 60 and older will take daily blood pressure readings and answ…

This study is developing an artificial intelligence system to analyze CT scans of the heart. The goal is to automatically detect and measure dangerous plaque that can cause heart attacks. Researchers will compare the AI's findings with detailed imaging tests and track patient out…

This study is testing a new finger-prick blood test that measures troponin levels in about 10 minutes, compared to the usual 2-hour lab test. Researchers hope it will help diagnose heart attacks faster and reassure patients who are not having one, allowing them to be discharged s…

This study looks at whether adding just 3 minutes to a cardiac MRI can help doctors find heart inflammation (myocarditis) early in cancer patients on immunotherapy. Myocarditis is a rare but often deadly side effect of these drugs. The researchers will scan 200 patients who alrea…

This study tests a new, non-invasive ultrasound method called electromechanical wave imaging (EWI) to see if it can more accurately locate and diagnose heart rhythm problems compared to standard tests. About 322 adults already scheduled for a heart procedure will get an EWI scan …

This large UK study (EVAREST) aims to improve how doctors interpret stress echocardiograms for diagnosing coronary artery disease. Researchers will collect blood samples and analyze echocardiogram images from up to 23,000 patients to find new biomarkers that make diagnosis more a…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can detect more cases of hidden atrial fibrillation (a heart rhythm problem that raises stroke risk) than the usual 24-hour Holter monitor. Researchers will enroll 320 adults who recently had a stroke …

This study enrolls 800 patients having heart attacks to test an artificial intelligence model that reads standard 12-lead ECGs. The AI aims to detect which artery is blocked and how severely blood flow is reduced, at the moment of a heart catheterization. If accurate, this could …

This study tests whether an artificial intelligence program can use a simple, single-lead handheld ECG device to find people with undiagnosed atrial fibrillation (AF), a common heart rhythm problem. About 200 adults aged 50-90 will use a device at home and complete surveys. The g…

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

Researchers are testing whether combining pulsed-field ablation with left atrial appendage occlusion in a single procedure can control atrial fibrillation and prevent stroke. The trial enrolls 200 adults with non-valvular atrial fibrillation and a higher stroke risk. Participants…

This study tests whether the diabetes drug metformin, combined with lifestyle changes like diet and exercise, can reduce episodes of atrial fibrillation (an irregular heartbeat) in people with pacemakers or defibrillators. About 175 participants will take metformin or a placebo a…

Researchers test whether cutting certain nerves around the heart during open-heart surgery can prevent atrial fibrillation, a common irregular heartbeat after the operation. The trial enrolls 560 adults scheduled for elective open-heart surgery. Half receive standard surgery plus…

Researchers test whether flecainide, an antiarrhythmic drug, can prevent atrial arrhythmias in adults who have a patent foramen ovale (PFO) closed after a cryptogenic stroke. Participants receive flecainide or standard care for 3 to 6 months. An insertable cardiac monitor records…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This trial tests whether routinely screening heart attack patients for H. pylori, a common stomach bacteria, can prevent upper gastrointestinal bleeding. The bacteria can cause ulcers that bleed, especially when patients take blood thinners after a heart attack. Researchers will …

This trial tests whether intensive heart rhythm monitoring after a stroke can prevent another stroke. People who have had a stroke may have atrial fibrillation, a heart rhythm problem that comes and goes and is easy to miss. Researchers compare standard care with extra monitoring…

This trial tests whether a structured prevention bundle can reduce delirium in adults aged 70 and older admitted to a cardiac intensive care unit (CICU). Participants are randomly assigned to either usual care or the bundle, which includes daily pain checks, avoiding sedatives wh…

This trial is testing a device called the Vine™ Embolic Protection System, which is implanted in the carotid arteries to trap blood clots before they travel to the brain. It is designed for people with atrial fibrillation who are already taking blood thinners but still have a hig…

This study was designed to see if treating a common stomach bacteria (H. pylori) along with using a stomach acid drug could prevent ulcers caused by low-dose aspirin. It planned to enroll adults with heart or artery disease who needed long-term aspirin therapy. However, the study…

Researchers are testing whether a suture-based closure device helps patients recover faster after heart procedures that use a large tube placed in the femoral vein. The trial enrolls adults undergoing procedures such as atrial fibrillation ablation, leadless pacemaker insertion, …

Researchers are testing whether isometric handgrip training, squeezing an inflatable ball in a steady hold, can lower resting blood pressure in people doing cardiac rehabilitation from home. Adults with coronary artery disease who are cleared for exercise-based rehab join the stu…

Researchers are testing whether Azerbaijani national dance sessions can improve cardiorespiratory fitness and quality of life in older adults with chronic heart failure. The trial enrolls 120 people aged 65 to 85 whose heart failure is confirmed by an ejection fraction between 40…

After coronary artery bypass grafting, doctors place tubes to drain fluid from around the heart. This trial compares two ways of monitoring that drainage: using gentle negative pressure (suction) or letting it drain on its own. Researchers will track fluid buildup around the hear…

This study tests whether a 12-week web-based support program can improve wellbeing in adults who survived a cardiac arrest 1 to 3 months earlier. The program includes educational modules, videos, breathing exercises, and a chat forum. Researchers will compare 120 participants who…

Doctors close the groin vein puncture after atrial fibrillation ablation either with a suture-based device called Perclose ProGlide or with a traditional figure-of-8 stitch. This trial randomly assigns 90 adults to one of the two methods and asks them how satisfied they are with …

Researchers are testing whether dapagliflozin, a daily oral drug, helps people with refractory heart failure who are on peritoneal dialysis remove more salt and fluid. The trial compares two 12-week periods: one with dapagliflozin added to usual care and one without. About 31 adu…

This study tests whether a 14-week elastic band exercise program can improve muscle mass, strength, and physical function in heart failure patients aged 50 and older who also have sarcopenia (age-related muscle loss). Researchers will measure changes in muscle, symptoms, and qual…

This study tests a digital program called TPA4You for older adults (50+) who care for a family member with heart failure. The program uses a Fitbit, video coaching, and text messages to encourage physical activity. The goal is to see if it's feasible and helps improve caregivers'…

This study tests a new medicine called ziltivekimab in 680 adults with heart failure and signs of inflammation. Participants will receive either the drug or a placebo for up to 16 months. The goal is to see if the drug improves heart failure symptoms and physical function, like b…

This study looks at the long-term safety and effectiveness of odevixibat in 70 people with Alagille syndrome, a rare genetic condition that affects the liver and other organs. The drug aims to reduce severe itching and improve bile flow. Participants who completed a prior 24-week…

Many Veterans with heart failure or COPD struggle with breathlessness, fatigue, depression, and anxiety that routine care often misses. This study tests whether a virtual team—a nurse and a social worker—can improve quality of life by helping Veterans manage their most bothersome…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve symptoms, exercise ability, and quality of life in 150 adults with a type of heart failure called HFpEF who also have iron deficiency. Participants will receive either the iron infusion …

This trial tests whether a structured therapeutic education program, delivered by general practitioners, can improve quality of life for people with heart failure. Around 200 patients in primary care will be randomly assigned to receive the program or usual care, and their qualit…

This study tests a new exercise program for people with coronary artery disease who have had heart surgery or a stent. The program combines high-intensity interval training with Nordic walking (walking with poles). Researchers want to see if it is safe, enjoyable, and better at i…

This study tests whether adding two ultrasound-guided nerve blocks to standard pain relief can lower opioid use and pain after coronary artery bypass grafting. 88 adults having elective bypass surgery will be randomly assigned to receive either the nerve blocks plus standard medi…

This study tests whether an 8-week mindfulness meditation program (MBSR) can reduce anxiety and depression in heart patients who have completed cardiac rehab. About 74 participants will either take the meditation course or continue with standard rehab. Researchers will measure ch…

This study tests a simpler deep-sedation method for people having a heart procedure called pulsed-field ablation to treat atrial fibrillation (an irregular heartbeat). The goal is to see if the new sedation approach is safe and makes patients more comfortable. About 40 adults wil…

This study tests whether peer health coaching—support from someone with similar experiences—can help young adults (ages 18-26) with congenital heart disease better manage their condition. Participants receive coaching via secure phone calls and texts over 6 months. The goal is to…

This study compares two types of heart bypass surgery for people with blocked arteries: a minimally invasive approach using small incisions between the ribs versus the traditional method that opens the breastbone. Researchers want to see if the less invasive surgery leads to bett…

This study tests a simple, non-invasive device that gently stimulates a nerve in the ear (tVNS) to see if it can improve cognitive function in people over 60 with atrial fibrillation. For 6 months, 60 participants will use the device daily after exercise. Researchers will measure…

This study tests whether adding group weight-loss classes to standard cardiac rehabilitation helps people with atrial fibrillation and obesity lose at least 10% of their body weight. About 120 adults will take part, with half getting the extra classes. The goal is to see if this …

This study tests whether a small shot of nitroglycerin under the skin can widen the wrist artery, making it easier for doctors to insert a tube for heart procedures. It involves 1,400 adults with coronary artery disease scheduled for heart catheterization. The goal is to reduce t…

This study tests whether empagliflozin, a drug typically used for diabetes, can help people with hypertrophic cardiomyopathy (a thickened heart muscle) who do not have diabetes. About 250 adults will receive either the drug or a placebo daily for 12 months. The main goals are to …

This study tests whether high-flow oxygen therapy can prevent low oxygen levels (hypoxemia) in patients at higher risk during sedated digestive endoscopy. The trial includes 326 adults with obesity, sleep apnea, or stable lung or heart conditions. Researchers will compare high-fl…

This study tests a new device called the EDEN system that records and classifies electrical signals from the heart during medical procedures. About 50 adults having heart procedures for ventricular arrhythmia or pacing will participate. The device works alongside standard equipme…

This study tests a personalized approach to find the best beta-blocker dose for older adults with heart failure. Fifty participants will either receive the N-of-1 intervention (testing different doses in 2-week cycles) or enhanced usual care. The goal is to see if this patient-dr…

This study will collect blood, urine, stool, and DNA samples from 2000 adults with heart failure to better understand how the disease progresses. Researchers will analyze proteins and other factors linked to declining heart function. Participants will be followed for up to 5 year…

This study looks at oxygen levels in the kidneys of premature babies born before 32 weeks who have a heart condition called patent ductus arteriosus (PDA). Researchers want to see how kidney oxygen relates to the severity of the heart condition and whether it can predict kidney i…

Researchers are running an international registry to follow adults who had an ischemic stroke or transient ischemic attack and also have a patent foramen ovale, a small opening between the upper chambers of the heart. The registry collects real-world information on how these pati…

Researchers are comparing two ways of finding atrial fibrillation in people who have had an ischemic stroke or a transient ischemic attack (TIA). One method uses a standard electrocardiogram (ECG) in the hospital, and the other uses a prolonged cardiac monitor worn for a longer p…

This study looks at people with late-onset Pompe disease to measure antibodies against a virus used in gene therapy and against the standard enzyme replacement therapy. It also checks for biomarkers in blood and urine. About 119 teenagers and adults will give samples over 2 years…

This study explores whether artificial intelligence (AI) combined with data from a smartwatch can predict serious heart failure events, such as hospitalizations or worsening symptoms. Adults with heart failure will wear a smartwatch for six months and take weekly ECG readings. Th…

This study collects blood and other samples from people with sickle cell disease and healthy volunteers to help researchers understand how inflammation affects blood vessels. Up to 2,000 adults aged 18 and older will take part. The samples will be used in lab tests to support fut…

Infective endocarditis is an infection of the heart's inner lining or valves. About half of patients need surgery during their hospital stay, while others receive antibiotics alone. Researchers are following 1,046 adults with confirmed endocarditis for up to 24 months to compare …

This pilot study looks at biomarkers in the blood of people with fragile sarcolemmal muscular dystrophy, a condition that makes muscle membranes weak. Researchers will collect blood samples at rest and after exercise during four 5-day hospital stays. The goal is to better underst…

This registry is collecting data from 20,000 people with coronary artery disease to see if an AI tool that analyzes CT scans of the heart can help doctors make better treatment decisions. The AI measures the amount and type of plaque in the arteries. Researchers will compare how …

This study aims to uncover the genetic roots of atrial fibrillation, a common heart rhythm disorder. Researchers are collecting blood samples and health data from 1,300 adults—some with the condition and some without—to compare their DNA. The goal is to identify genetic variants …

Researchers at University Hospital Freiburg are studying how blood levels of hsCRP and Lp(a), two markers linked to heart disease, change over time in patients who have had these tests more than once. The study asks whether a high result on a first test often returns to normal la…

This registry will follow 3,500 adults with atrial fibrillation who have a low risk of stroke. Researchers will track complications like stroke and hospitalizations over time to see how patients are managed in everyday medical practice. The goal is to better understand outcomes a…

Researchers are building a registry to follow adults with recurrent pericarditis, a condition where inflammation around the heart keeps coming back. The registry collects information over time on how often flare-ups happen, what treatments patients receive, and whether they are h…

This study tests whether a balloon device, called REBOA, can be safely used by emergency teams outside a hospital to improve blood flow in people whose heart has stopped (cardiac arrest). The balloon is inserted into the main artery and inflated to redirect blood to the heart and…

Researchers at Chungnam National University Hospital are studying blood and cerebrospinal fluid from adults who had an out-of-hospital cardiac arrest and received post-resuscitation care. The goal is to map molecular changes over time and see how they relate to the severity of br…

This Phase 1 trial investigates how the drug HRS-9057 is absorbed, processed, and eliminated in healthy men. Six participants receive a single dose, and researchers measure the drug and its breakdown products in blood, urine, and stool. The goal is to understand the drug's behavi…

This study is an early-stage trial to check the safety of a new drug called RO7763505. It involves 196 participants, first in healthy volunteers and then in people with stable coronary artery disease. The main goal is to see if the drug is safe and how the body processes it, not …

This study is testing a new video game designed to help teenagers with congenital heart disease learn how to manage their own healthcare. The game teaches skills like talking to doctors, understanding medical information, and keeping track of appointments and medications. About 1…

This study enrolls adults aged 60 and older who are already participating in a larger trial comparing two ways to repair a leaky mitral valve. Researchers will use heart MRI scans, wearable heart monitors, and tissue samples to look for scarring in the heart muscle and abnormal h…

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The model alerts doctors when a child may need a palliative care consultation. Researchers will compare outcomes before and after the model is used, involving …

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This study looks at 500 women with chest pain to compare two tests used during heart catheterization—FFR and iFR—to see which better predicts future heart problems like heart attacks or strokes. Participants will be followed for 5 years. The goal is to improve how doctors decide …

Researchers in Uzbekistan are studying common respiratory and heart conditions in children from birth to age 15. They will analyze medical records and examine blood samples to understand immune and antioxidant function in affected children. The goal is to develop and test improve…

This study follows 20 newborns and children diagnosed with late-onset Pompe disease through newborn screening. Researchers will track their health for up to 4.5 years to document early muscle and joint symptoms, biomarkers, and quality of life. The goal is to learn when to start …

This observational study follows 95 people with heart failure and preserved ejection fraction who are already receiving weight loss treatment as part of their standard care. Researchers will measure muscle blood flow, fat content, and inflammation before and after at least 7% wei…

This study gathers health information from children under 18 who have cardiomyopathy linked to mutations in the MYBPC3 gene. Researchers aim to map the disease's natural course, identify risk factors, and measure how it affects quality of life. By reviewing past and future medica…

This observational study looks at how lowering body temperature during heart-lung bypass surgery affects two common brain monitors (BIS and PSI). Researchers will track 60 adults undergoing planned coronary bypass surgery. The goal is to see if the monitors' readings change diffe…

This study looks at two ways of managing anesthesia during non-intubated video-assisted thoracoscopic surgery (NIVATS), a type of chest surgery where patients breathe on their own without a breathing tube. Researchers will review records of 120 adults who had this surgery to crea…

This study tracks how paramedics use the ZOLL 731 ventilator when helping people with serious conditions like cardiac arrest, sepsis, or heart failure before they reach the hospital. Researchers will record which ventilator modes and settings are used, and how often alarms go off…

This study tests whether the pressure gradient across an intentionally created atrial septal defect, measured right after a minimally invasive mitral valve repair called M-TEER, can indicate how much mitral regurgitation remains. Researchers will compare this gradient with echoca…

This study follows 200 adults in Western Denmark who are having a transcatheter aortic valve implantation, a procedure to replace a narrowed heart valve. Researchers will measure quality of life before the procedure and at follow-up using a standard questionnaire. They will also …

This study looks at how frailty, a measure of biological age, influences the care and outcomes of patients hospitalized with a heart attack. Researchers will analyze data from the Swedish SWEDEHEART registry, which includes information on thousands of patients. They will compare …

This study follows 250 people with high blood pressure and 60 healthy volunteers over several years. Researchers use heart imaging and blood tests to track changes in heart structure and function. The goal is to understand why some people with hypertension develop heart failure, …

This study is testing whether a wearable ECG patch, combined with AI analysis, can help doctors identify a wide range of heart conditions and risks from a single recording. The Cor360 system looks at many aspects of heart health at once, such as heart failure, rhythm problems, an…

This study is looking at people hospitalized for a heart attack (STEMI or NSTEMI) who undergo a procedure to open blocked heart arteries, called percutaneous coronary intervention (PCI) or angioplasty. It compares two groups: those having a standard (non-complex) PCI and those ha…

This observational study will enroll about 8,000 adults across Europe who have coronary heart disease or are at high risk for it, including those with diabetes or chronic kidney disease. Researchers will check whether doctors are following European guidelines for lifestyle advice…

This observational study aims to capture a real-world snapshot of how heart failure is managed across Europe and worldwide. Researchers will collect data from about 4,000 adults with chronic or acute heart failure, looking at whether routine care aligns with the 2021 ESC guidelin…

This study follows about 5,000 people with coronary artery disease who are treated with a paclitaxel drug-coated balloon angioplasty, a procedure that opens narrowed heart arteries and releases medication to help keep them open. Researchers are combining past medical records with…

This study is developing a digital twin—a virtual model of the heart and blood vessels—to better understand and manage hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researchers will gather detailed health data from 2500 people with HCM or the gen…

This study follows 250 male endurance athletes who were part of an earlier study to see how their heart arteries have changed over time. Researchers will use CT scans and AI to examine plaque buildup and determine if it is stable and harmless or likely to cause heart attacks. The…

This study looks at whether a new computer algorithm can predict if atrial fibrillation (an irregular heartbeat) will come back after a common treatment called pulmonary vein isolation. Researchers will review medical records from 300 patients who had this procedure. The goal is …

This study looks at whether sensors inside implanted heart devices can warn of worsening heart failure. Researchers will track 500 adults with heart failure or cardiomyopathy who have a Boston Scientific ICD or CRT-D equipped with HeartLogic, Sleep Incline, and Apnea Scan functio…

This registry follows 500 people receiving a specific type of surgical aortic valve replacement (the INSPIRIS RESILIA valve) for up to five years. Researchers are tracking how pre-existing conditions like kidney disease, diabetes, and high blood pressure affect survival and valve…

This study examines genetic test results from over 600 people who had acute myocarditis (heart muscle inflammation) confirmed by MRI. Researchers want to find out how common certain gene variants are in this group and whether they are linked to worse outcomes like heart failure o…

This study aims to better understand atrial fibrillation (AFib), the most common abnormal heart rhythm. Researchers will use mobile devices like ECG patches and a smartphone app to monitor heart rhythm, activity, and sleep in 3,000 adults, some with AFib and some without. Partici…

This study collects blood and tissue samples from up to 500,000 adults, including heart patients, their family members, and healthy individuals. Researchers will analyze these samples to find molecular and genetic markers linked to heart disease. The goal is to improve understand…

This pilot study investigates whether a continuous remote ECG monitor, worn as a chest patch, can predict hospital readmission or death within 30 days after discharge in patients with heart failure and atrial fibrillation. Fifty participants will wear the Vivalink ECG patch at ho…

This study looks at whether detailed analysis of heart MRI images (called radiomics) can better predict life-threatening heart rhythms in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researchers will also see if the drug mavacamten, …

This pilot study tests whether a simple 'Talk Test' can safely and effectively prescribe exercise for heart patients recovering at home after bypass surgery or stent placement. Forty participants will be randomly assigned to get exercise instructions based on either the Talk Test…

This observational study looks back at 22,000 adults in Sweden diagnosed with infective endocarditis, a serious heart valve infection, since 1997. By linking national health records, researchers aim to understand which patients benefit most from valve surgery and what factors aff…

This study looks at whether bosentan, a drug that blocks a natural vessel-constricting substance, can improve blood flow in the tiny heart vessels of people with angina who have no major blockages. About 45 participants will get bosentan for 4 weeks and have MRI scans before and …

This study is gathering health information from 4,600 people in rural areas of Alabama, Kentucky, Louisiana, and Mississippi. Researchers will look for risk factors that lead to heart and lung disease. No treatments or drugs are being tested. The goal is to learn more about what …

This study follows over 3,400 adults who have had a heart stent procedure to understand how continuity of care, health literacy, and medication adherence influence their long-term health. Researchers will track hospital readmissions, medication use, and patient-reported outcomes …

This study looks at why people who have had an organ transplant are more likely to get cancer. Researchers will combine existing health records from over 85,000 transplant patients in England to track cancer cases and deaths. The goal is to better understand risks and improve car…

This study was designed to compare electrical and mechanical activation of the right ventricle in adults who had surgery for Tetralogy of Fallot, a congenital heart condition. Researchers planned to use 3D mapping and imaging to see if electrical signals match the heart's physica…

This study tests whether a special CT scan (CCTA) of the heart can predict if atrial fibrillation will come back after a standard ablation procedure. Researchers will scan patients before their first ablation and then follow them for a year. The goal is to see if heart structure …

This study follows 280 people with mitral valve prolapse over 3 years to see if heart MRI scans and blood tests can predict who will develop dangerous heart rhythms or heart muscle changes. Participants undergo MRI, blood draws, and heart monitoring. The goal is to find early war…

This study looks at 90 people who recently had a heart attack and have other artery narrowings that may or may not be dangerous. Researchers will use two types of scans—optical coherence tomography (OCT) and magnetic resonance angiography (MRA)—to see if they can tell which narro…

This study tracks 130 people with chronic heart failure to understand how taking multiple medications (polypharmacy) affects their safety, adherence, and health outcomes. Researchers will look for patterns of over- or under-prescribing and factors linked to low medication adheren…

This study compares a new X-ray system (Azurion R4.0) to an older version during heart procedures like angiography. The goal is to see if the new system lowers the radiation dose patients receive while still allowing doctors to work effectively. About 824 adults from several coun…

This study looks at whether telling people they have a high genetic risk for heart disease helps them make healthier choices. About 200 adults without heart disease will be followed for one year. Researchers will compare heart health scores between those who learn their genetic r…

This study tests whether artificial intelligence can help doctors see heart valve structures more clearly during a minimally invasive repair procedure called TEER. Researchers will use data from 1,500 patients who have already had the procedure to train and test the AI. The goal …

This study reviewed medical records of 1000 people who received a special balloon treatment (drug-coated balloon angioplasty) for blocked heart arteries between 2009 and 2015. Researchers tracked major heart problems like death, heart attacks, or need for repeat procedures for up…

This study looks at women who have had a heart attack or unstable angina but do not have major blockages in their heart arteries. Doctors will use special imaging techniques, like IVUS and MRI, to find hidden causes such as cholesterol plaque in artery walls or problems with tiny…

This study is enrolling 15,000 adults who are already scheduled for a coronary CT angiography (CCTA) scan. Researchers will analyze the scan images along with participants' health outcomes over time. The goal is to see if detailed information from the scans can help doctors more …

This study is for heart failure patients who do not have a specific heart rhythm pattern called left bundle branch block (non-LBBB). These patients often get a device called CRT-D, which combines a pacemaker and a defibrillator, but not everyone responds well. Researchers will fo…

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

This study looks at whether adding a stress CT scan that checks blood flow to the heart muscle helps doctors decide the best treatment for people with known or suspected heart disease. About 2000 adults will be followed to see if this extra test reduces the need for more tests an…

This study looks at whether training nurses with realistic simulations helps them perform CPR and use defibrillators better during cardiac arrest. About 134 experienced nurses will take part. The goal is to improve patient survival by boosting nurses' skills.

This pilot study looks at whether a simple, non-invasive eye scan (OCT-A) can detect early signs of memory decline in people with atrial fibrillation, a common heart rhythm disorder. Researchers will compare retinal blood vessel patterns in 40 patients with and without mild cogni…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study examines whether a low pulse pressure (the difference between top and bottom blood pressure numbers) in the first hours after a cardiac arrest is linked to early death. Researchers will analyze data from 3500 patients who had a cardiac arrest outside the hospital and a…

This study looks at whether diabetes or blood sugar problems can worsen thinking and memory issues in people with myotonic dystrophy type 1. Researchers will use MRI brain scans and thinking tests over 4 years to track changes. The goal is to understand why some patients have mor…

This study looks at whether a special heart MRI, done within a week of a heart attack, can help doctors better predict a patient's future health. Researchers will follow 2,000 adults for years to track serious heart events like another attack or heart failure. The goal is to lear…

This study collects data from 1,200 patients undergoing surgery for aortic dissection, a life-threatening tear in the heart's main artery. Researchers will track death rates, strokes, and other complications to identify the safest surgical strategies. The goal is to improve outco…

This study follows 500 people with peripheral artery disease (PAD) who undergo a procedure to open blocked leg arteries. Researchers check blood and heart ultrasound before and after the procedure to find hidden heart injury. The goal is to see if certain markers can predict futu…

This study looks at whether a special MRI scan can detect early scarring in the heart muscle of people with leaky heart valves. The goal is to find a way to predict when the heart might start to fail, so doctors can decide on surgery sooner. About 316 adults with moderate to seve…

Over two million people in the UK have a chronic condition like diabetes or heart disease without knowing it. This study will use information from 4.5 million hospital patients to build a digital platform that spots those at risk. The goal is to help doctors diagnose these condit…

This study follows 100 ICU patients who developed new atrial fibrillation (AF) during their stay. Using a chest-worn heart monitor, researchers track whether AF returns after leaving the ICU and up to 3 months after hospital discharge. The goal is to understand who might need lon…

This study is looking at whether an artificial intelligence tool can help doctors decide which heart surgery patients might benefit from a drug called ulinastatin. Ulinastatin is used to reduce inflammation after surgery, but it doesn't work for everyone. Researchers will analyze…

This study looks at whether giving a personalized dose of a radioactive tracer (rubidium-82) based on a patient's weight can improve the quality of PET heart scans. Researchers will enroll 48 adults with known or suspected heart disease and divide them into four weight groups. Th…

This study looks at two methods for treating atrial fibrillation (an irregular heartbeat) using a special balloon catheter. The goal is to see if using a 3D mapping system (CARTO) makes the procedure faster and safer than using X-ray guidance alone. About 60 adults with paroxysma…

This study looks at how a common heart valve procedure called TAVI changes the gut microbiome in older adults with aortic stenosis. Researchers will collect blood and stool samples before and three months after TAVI to measure bacterial byproducts and diversity. The goal is to se…

This study follows 331 adults with hypertrophic cardiomyopathy (HCM) to see how they are treated in everyday medical practice, especially with the drug mavacamten. Researchers will collect data on diagnosis, symptoms, treatments, and outcomes over time. The goal is to understand …

This study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …

This study looks at whether a new screening system can help doctors find heart complications early in high-risk patients after noncardiac surgery. Researchers will track 900 patients to see how well the screening works in practice and what it costs. The goal is to gather informat…

This large real-world study will follow 10,000 Italian patients with COPD to see how their treatments, flare-ups, and other health conditions affect their risk of death. Researchers will collect data on medications, lung function, and heart problems over time. The goal is to bett…

This study looks at whether a pre-surgery test called FFR can predict how well arterial bypass grafts work six months after coronary artery bypass grafting (CABG). About 120 patients with multi-vessel heart disease will have an FFR test during their diagnostic angiogram. Six mont…

This study is a large international registry that will collect data from up to 130,000 people who have had a heart attack or unstable chest pain. Researchers will track treatments, outcomes, and safety to understand what works best in real-world care. No new drugs or devices are …

This study tests whether adding automatic reminders to echocardiogram (heart ultrasound) reports can increase the number of patients with heart valve disease who see a cardiologist within six months. Researchers will randomly assign 300 patients' reports to receive no prompt, a p…

This study is a registry that collects information and blood samples from over 2,400 people with atrial fibrillation who are scheduled for a heart procedure called ablation. The goal is to learn which patients benefit most from the procedure and to better understand what causes a…

This study checks if insulin resistance (when your body doesn't use insulin well) can predict whether a heart procedure called pulsed field ablation will work for people with atrial fibrillation (an irregular heartbeat). About 120 non-diabetic patients having their first ablation…

This study aimed to compare two versions of the water pill torsemide (extended release vs immediate release) in adults with stable heart failure. Participants would have taken each version for a week, then had their sodium excretion measured after a single dose and a salty lunch.…

This study looks at 224 adults who had surgery as children for a heart defect called tetralogy of Fallot. Researchers are using MRI scans and blood tests to measure scarring in the heart muscle. They want to see if this scarring is linked to serious heart problems like arrhythmia…

This study looks at real-world data from 6,000 heart failure patients to compare a newer pacing method (conduction system pacing) with the standard method (biventricular pacing). The goal is to see if the newer approach is just as safe and effective at reducing heart failure hosp…

This study looks at whether giving doctors early results from heart biomarker tests (NT-proBNP and hs-cTnT) along with a structured interpretation note can improve outcomes for patients admitted with rapid breathing (tachypnea). About 574 adults will be randomly assigned to recei…

This study looks at 600 adults with non-compaction cardiomyopathy, a rare heart muscle condition that can lead to heart failure, stroke, or dangerous heart rhythms. Researchers will use heart scans, genetic tests, and health records to find better ways to predict who is at highes…

This study looks at whether mepolizumab, a drug already used to reduce asthma attacks, can also improve physical activity and exercise tolerance in people with severe asthma. Researchers will track daily steps and activity levels in 62 adults over six months. The goal is to see i…

This study looks at 2,000 people who had a heart attack to see if checking the stiffness of their blood vessels one month later can help predict future heart failure, another heart attack, or bleeding. Researchers will track participants for several years to identify which measur…

This study looks at 57 people who received a COVID-19 vaccine to understand why some develop heart injury or myocarditis. Researchers use advanced heart scans (PET/MRI) and blood tests to find early warning signs. The goal is to better identify those at risk and improve follow-up…

This study was designed to compare a newer pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in patients who developed heart block after TAVR valve replacement. The goal was to see which method better preserves heart function and r…

This study looks at 40 people who recently had a heart attack and had one blockage treated. Researchers will use special pressure wires and optical imaging to examine other blockages that were not treated. The goal is to see how many of these leftover blockages are actually dange…

This study looks at how doctors treat people having a severe heart attack complicated by cardiogenic shock, where the heart can't pump enough blood. Researchers will track 124 patients at 20 U.S. hospitals to see how decisions about using mechanical heart support devices affect s…

This study tracks 40 people with nasal polyps and severe asthma who are taking mepolizumab, a drug that reduces inflammation. Researchers collect nose, blood, and sputum samples before treatment and at 3, 6, and 12 months to see how the drug affects symptoms, nose bacteria, and g…

This small pilot study is testing whether a gentle, non-invasive electrical stimulation on the ear (auricular vagus nerve stimulation) can change how the heart's electrical system works. Ten people who are already scheduled for a heart procedure will receive the stimulation while…

This study follows 2,600 adults with coronary heart disease and depression who received a stent. Researchers track major heart problems like heart attacks or death over one year to find what predicts these events. The goal is to better understand the link between depression and h…

This study was designed to see if a test using acetylcholine could predict whether people with congenital heart disease and high blood pressure in the lungs would develop worsening high blood pressure after surgery to close a heart shunt. The test would have measured how well the…

This study looks at whether a heart valve replacement procedure called TAVI can be safely performed in hospitals that do not have on-site cardiac surgery backup. It involves 657 patients with severe aortic stenosis who are at high risk for surgery. The same experienced doctors pe…

This study looks at whether a simple, painless eye ultrasound can help doctors predict brain damage and survival in people who have had a cardiac arrest. Researchers will measure the optic nerve sheath diameter in 80 adults and compare it with other tests. The goal is to find a f…

This study tests whether using an ultrasound measure of heart muscle coordination (mechanical dyssynchrony) can better select heart failure patients for cardiac resynchronization therapy (CRT) than current guidelines. About 500 patients will receive a CRT device, but pacing will …

This study tests whether using game-like rewards and personal coaching can encourage older adults to walk more after leaving the hospital. About 350 people aged 50 and older with conditions like high blood pressure or heart failure will wear a Fitbit to track their steps. The goa…

This study follows 50 athletes who had acute myocarditis (heart muscle inflammation) to see how often they develop dangerous heart rhythms. Participants wear a portable ECG monitor and do a treadmill stress test at 3 months and 1 year after their illness. The goal is to learn mor…

This pilot study looks at whether light, self-paced swimming is a tolerable activity for people with ME/CFS and related conditions like Long COVID and fibromyalgia. Participants will swim for 15-30 minutes at their own pace and track symptoms and heart rate variability using an a…

This study is looking for the genetic causes of bicuspid aortic valve disease, a common heart condition where the aortic valve has two flaps instead of three. Researchers will analyze DNA from 11,000 participants, including patients and their relatives, to find gene changes linke…

This study gathers genetic and health information from over 6,400 people with bicuspid aortic valve, a common heart defect. Researchers aim to find the genes responsible for the condition and why some patients later develop serious aortic disease. No treatment is given; the goal …

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study tests whether a virtual group program can help people who survived a cardiac arrest and their relatives. About 50 participants will either join the virtual group or receive a digital booklet. The goal is to see if the program is practical and helpful for improving reco…

This study tests whether a small device placed under the skin can detect hidden atrial fibrillation (an irregular heartbeat) in people with heart failure who are at high risk for stroke. About 477 participants either received the implant or standard care. The goal is to see if th…

This study watches 50 people with chronic lymphocytic leukemia (CLL) who are starting a type of drug called a BTK inhibitor. These drugs can cause high blood pressure and irregular heartbeats. Participants will use a wearable device at home to track their heart rhythm and blood p…

This study examines whether SGLT2 inhibitors, a type of diabetes drug, can improve red blood cell production and heart/kidney function in people with chronic heart failure. Researchers will compare blood tests, heart ultrasound measures, and clinical outcomes between 85 patients …

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This study looks at whether giving pharmacists extra education plus monthly feedback on their performance helps them adjust heart failure medications more often than just education alone. About 400 pharmacists across 22 VA sites will take part. The goal is to see if simple change…

This study tests a smartphone app that listens to your voice to catch early signs of heart failure getting worse. 123 people who were in the hospital for heart failure will record their voice daily for 6 months. The app looks for voice changes that might signal a problem, but doc…