New heart study aims to cut unnecessary pacemaker implants by half
NCT ID NCT04225520
First seen Jun 24, 2026 · Last updated Jun 24, 2026
Summary
This study tests whether using an ultrasound measure of heart muscle coordination (mechanical dyssynchrony) can better select heart failure patients for cardiac resynchronization therapy (CRT) than current guidelines. About 500 patients will receive a CRT device, but pacing will be turned on or off based on their dyssynchrony status in the experimental group. The goal is to see if this approach reduces the number of people who get a device without benefit, while maintaining good outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AZ Damiaan
Ostend, 8400, Belgium
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AZ Delta
Roeselare, 8800, Belgium
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AZ Maria Middelares
Ghent, 9000, Belgium
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AZ Sint-Jan Brugge
Bruges, 8000, Belgium
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CHRU Brest
Brest, 29200, France
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CHU Rennes - Pontchaillou Hospital
Rennes, 35000, France
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CHU de São João
Porto, 4200-319, Portugal
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Dante Pazzanese Institute of Cardiology
São Paulo, 04012-909, Brazil
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Ghent University Hospital
Ghent, 9000, Belgium
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Groupements des hôpitaux de l'institut catholique de Lille
Lille, 59800 Lille, France
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Heart Institute Nicolae Stancioiu
Cluj-Napoca, 400001, Romania
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Hospital Clínico de Barcelona
Barcelona, 08036, Spain
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Klinika Wad Wrodzonych Serca
Warsaw, 04-628, Poland
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Paul Stradins Clinical University hospital
Riga, LV-1002, Latvia
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Poznan University of Medical Sciences
Poznan, 61-701, Poland
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Semmelweis University Heart Center
Budapest, 1122, Hungary
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Silesian Center for Heart Diseases
Zabrze, 41-800, Poland
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St. Vinzenz-Hospital
Cologne, 50733, Germany
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UZ Leuven
Leuven, 3000, Belgium
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University Hospital Antwerp
Antwerp, 2000, Belgium
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Universitätsklinikum Würzburg
Würzburg, 97080, Germany
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Universitätsmedizin Rostock
Rostock, 18057, Germany
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Universitätsspital Zürich
Zurich, 8091, Switzerland
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ZNA Middelheim
Antwerp, 2020, Belgium
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cardiac resynchronization therapy (CRT) device implantation with bi-ventricular pacing turned on or off
What this could lead to
If successful, this could lead to a more precise way to select heart failure patients for CRT, reducing unnecessary implants and improving outcomes.
What could go wrong
This is an observational study comparing two selection methods, not testing a new treatment. The benefit depends on whether mechanical dyssynchrony reliably predicts response, which may not hold in all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.