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Balloon or stent? major trial tests safer option for clogged heart arteries

NCT ID NCT05846893

First seen May 31, 2026 · Last updated Jun 17, 2026 · Updated 4 times

Summary

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approach better prevents death, heart attacks, repeat procedures, or major bleeding.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cardiac Vascular Sentral Kuala Lumpur

    Kuala Lumpur, Kuala Lumpur, 50470, Malaysia

  • Chang Gung Memorial Hospital

    Taoyuan, 33305, Taiwan

  • Chonnam National University Hospital

    Donggu, Gwangju, 61469, South Korea

  • Far Eastern Memorial Hospital

    New Taipei City, 220216, Taiwan

  • Gyeongsang National University Changwon Hospital

    Changwon, Gyeongsangnam-do, 51472, South Korea

  • Inje University Ilsan Paik Hospital

    Goyang-si, Gyeonggi-do, 10380, South Korea

  • Kangbuk Samsung Hospital

    Seoul, Seoul, 13631, South Korea

  • Kangwon National University Hospital

    Chuncheon, Gangwon-do, 24289, South Korea

  • Keimyung University Dongsan Hospital

    Daegu, Daegu, 42601, South Korea

  • Khoo Teck Puat Hospital

    Singapore, 768828, Singapore

  • Korea University Ansan Hospital

    Ansan-si, Gyeonggi-do, 15355, South Korea

  • Korea University Guro Hospital

    Seoul, 08308, South Korea

  • National Heart Centre Singapore

    Singapore, 169609, Singapore

  • National Heart Institute Malaysia

    Kuala Lumpur, Kuala Lumpur, 50400, Malaysia

  • Queen Elizabeth II Hospital

    Kota Kinabalu, Sabah, 88300, Malaysia

  • Sarawak Heart Center

    Kuching, Sarawak, 94300, Malaysia

  • Sultan Idris Shah Serdang Hospital

    Kajang, Selangor, 43000, Malaysia

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Tan Tock Seng Hospital

    Novena, 308433, Singapore

  • Ulsan University Hospital

    Donggu, Ulsan, 44033, South Korea

  • University Malaya Medical Centre

    Kuala Lumpur, Kuala Lumpur, 59100, Malaysia

Conditions

The condition(s) this trial relates to.

acute coronary syndrome Angina Pectoris cardiovascular disorder Constriction, Pathologic coronary artery disorder Coronary Occlusion coronary stenosis heart disorder ischemic disease myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.