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Could a short course of steroids calm a dangerous heart rhythm?

NCT ID NCT06635863

Disease control Sponsor: Roderick Tung Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial tests whether an 8-week course of the immunosuppressive drug prednisone can reduce episodes of ventricular tachycardia (a potentially fatal fast heart rhythm) and improve heart function in people with non-ischemic cardiomyopathy and confirmed heart inflammation. Participants are randomly assigned to receive either prednisone plus standard heart-failure therapy or standard therapy alone. The study tracks heart rhythm, ejection fraction, and inflammation on PET scans to see if calming the immune system helps the heart.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an 8-week course of prednisone (an immunosuppressive steroid)
What this could lead to
If it works, this could offer a non-invasive treatment option for people with ventricular tachycardia linked to heart inflammation, potentially reducing the need for procedures or hospital stays.
What could go wrong
This is a small, early-phase trial with only 40 participants. Prednisone has known side effects, and the benefit may not be confirmed in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years of age, all races, all gender * LV systolic function \< 50% * Optimized GDMT Per physicians' discretion (SOC treatment) * No evidence of ischemic cardiomyopathy * No evidence of obstructive coronary disease * Viral panel negative * NYHA class II, III and ambulatory class IV heart failure * History of VA (documentation of Sustained VT last more than 30 seconds) * Heart inflammation confirmed by PET scan * Steroid use within 12 months prior to of date of consent Exclusion Criteria: * Life expectancy less than 24 months * Pregnancy * Contra indications or intolerance of prednisone or any excipients in the formulation * Hypothalamic-pituitary-adrenal axis suppression, Cushing's syndrome, active infection, glaucoma or any other pathology where corticosteroids are not recommended. * Any patient with HIV, low white blood cells, and chronic infection (active fungal, TB, Valley fever)

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Conditions

The condition(s) this trial relates to.

arrhythmogenic right ventricular cardiomyopathy cardiac rhythm disease intrinsic cardiomyopathy ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arrhythmogenic inflammatory cardiomyopathy Non-ischemic cardiomyopathy Ventricular arrythmia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Banner - University Medical Center, Phoenix campus

    Phoenix, Arizona, 85006, United States

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